Method for manufacturing medical device having a highly biocompatible surface

• US 5,128,170 A
• Filed: 05/09/1990
• Issued: 07/07/1992
• Est. Priority Date: 05/11/1989
• Status: Expired due to Term

• Current Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
• Original Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
• Inventors: Inoue, Kazuhiko, Tani, Nobutaka, Matsuda, Takehisa
• Primary Examiner(s): PADGETT, MARIANNE L
• Application Number:
  US07/520,902
• Time in Patent Office: 790 Days
• Field of Search: 427/2, 427/53.1, 427/54.1, 427/55, 427/56.1, 427/35, 427/36, 427/44
• US Class Current: 427/2.24
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 33/06 Use of macromolecular materials grafting of a monomer onto the substrate A61L33/0088

Abstract

A medical device having a highly biocompatible surface wherein hydrophilic polymer is bonded onto a surface of the medical device covalently through a nitrogen atom, and a method for manufacturing a medical device having a highly biocompatible surface comprising the steps of applying a hydrophilic polymer having azido group and/or a composition comprising a compound having at least two azido group and a hydrophilic polymer onto the surface of the medical device, and irradiating the biocompatible material with light so that the hydrophilic polymer is bonded to the medical device surface. The device has sufficient biocompatibility, medical functional capability and economical efficiency. The method easily provides a medical device with sufficient biocompatibility without impairing the device'"'"'s medical functional capability and economical efficiency.

Claims

1. A method for manufacturing a medical device having a highly biocompatible surface which comprises the steps of applying a composition comprising a compound having at least two azido groups and a hydrophilic polymer onto the surface of the medical device, and irradiating the applied composition with light to convert the azido groups to nitrene groups thereby bonding the hydrophilic polymer to the surface of the medical device and crosslinking the hydrophilic polymer.

2. A method for manufacturing a medical device having a biocompatible surface which comprises applying a least one biocompatible material onto the surface of the medical device, said at least one biocompatible material being selected from the group consisting of a hydrophilic polymer having at least two azido groups and a composition comprising a compound having at least two azido groups and a hydrophilic polymer;

and irradiating the applied biocompatible material with light to convert the azido groups into nitrene groups, thereby bonding the hydrophilic polymer covalently to the surface of the medical device and crosslinking the hydrophilic polymer.