Gas-permeable material with excellent compatibility with blood
First Claim
1. A gas-permeable material compatible with blood that is produced by steps comprising:
- preparing polyurethane or polyurethaneurea from reactants comprising diisocyanate, polysiloxane containing terminal hydroxyl groups or polysiloxane containing terminal amino groups, and polyol of formula IIa or polyamine of formula Va;
##STR8## wherein R13 and R14 each independently is an alkyl group containing 1-10 carbon atoms;
converting tertiary amino groups contained in the polyurethane or the polyurethaneurea to quaternary ammonium groups; and
treating the polyurethane or the polyurethaneurea having quaternary ammonium groups with heparin;
wherein the proportion by weight of the polysiloxane in the resulting polyurethane or polyurethaneurea is 30-85%, and the amount of tertiary amino groups in molecules included in the resulting polyurethane or polyurethaneurea is at a proportion of 0.05-2.00 mmol/g.
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Abstract
A gas-permeable material with excellent compatibility with blood comprising polyurethane, polyurethaneurea, or the derivatives thereof is provided. The polyurethane or polyurethaneurea is obtained from a composition that comprises diisocyanate; polysiloxane containing terminal hydroxyl groups; and polyol or polyamine containing at least one tertiary amino gorup. The derivatives of the polyurethane or polyurethaneurea is obtained by the following steps of: converting the tertiary amino groups contained in the polyurethane or the polyurethaneurea to quarternary ammonium groups, and treating the polyurethane or the polyurethaneurea having quarternary ammonium groups with heparin.
112 Citations
8 Claims
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1. A gas-permeable material compatible with blood that is produced by steps comprising:
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preparing polyurethane or polyurethaneurea from reactants comprising diisocyanate, polysiloxane containing terminal hydroxyl groups or polysiloxane containing terminal amino groups, and polyol of formula IIa or polyamine of formula Va;
##STR8## wherein R13 and R14 each independently is an alkyl group containing 1-10 carbon atoms;converting tertiary amino groups contained in the polyurethane or the polyurethaneurea to quaternary ammonium groups; and treating the polyurethane or the polyurethaneurea having quaternary ammonium groups with heparin; wherein the proportion by weight of the polysiloxane in the resulting polyurethane or polyurethaneurea is 30-85%, and the amount of tertiary amino groups in molecules included in the resulting polyurethane or polyurethaneurea is at a proportion of 0.05-2.00 mmol/g. - View Dependent Claims (2, 3)
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4. A gas-permeable material compatible with blood produced by steps comprising:
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preparing polyurethane or polyurethaneurea from reactants comprising diisocyanate, polysiloxane containing terminal hydroxyl groups or polysiloxane containing terminal amino groups, and polyesterpolyol containing an aminediol of formula IIb with dicarboxylic acid as a main component thereof, polyetherpolyol obtained by the condensation of aminediol of formula IIc or polyamide polyamine containing aminodiamine of formula Vb with dicarboxylic acid as a main component thereof;
##STR9## wherein R4 is a hydrogen atom or an alkyl group containing 1-5 carbon atoms, R5 is an alkyl group containing 1-20 carbon atoms, and R13 and R14 each independently is an alkyl group containing 1-10 carbon atoms;converting tertiary amino groups contained in the polyurethane or the polyurethaneurea to quaternary ammonium groups; and treating the polyurethane or the polyurethaneurea having quaternary ammonium groups with heparin; wherein the proportion by weight of the polysiloxane in the resulting polyurethane or polyurethaneurea is 30-85%, the amount of tertiary amino groups in molecules included in the resulting polyurethane or polyurethaneurea is at a proportion of 0.05-2.00 mmol/g, and the molecular weights of the polyesterpolyol, polyetherpolyol and polyamide polyamine are 500-8000. - View Dependent Claims (5, 6, 7, 8)
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Specification