Method and apparatus for controlling heart rate in proportion to left ventricular pressure

• US 5,129,394 A
• Filed: 01/07/1991
• Issued: 07/14/1992
• Est. Priority Date: 01/07/1991
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Mehra, Rahul
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Getzow, Scott M.
• Application Number:
  US07/638,286
• Time in Patent Office: 554 Days
• Field of Search: 128/419 PG, 128/419 D
• US Class Current: 607/23
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/36564 controlled by blood pressure

Abstract

A method and apparatus for sensing in vivo blood pressure proportional to the left ventricular pressure for detecting ventricular tachyarrhythmias or the cardiovascular status in congestive heart failure, and/or for adjusting the rate of a pacemaker. A lead with a pressure sensor near its distal end is placed transvenously through the coronary sinus and located in the coronary vein. When in place, a bulge or an inflatable balloon proximal to the pressure sensor may be used to acutely occlude the coronary vein until the sensor fibroses in. The balloon may be reinflated prior to pressure measurements. The pressure that is sensed in that location is proportional to the left ventricular pressure. Values representing the left ventricular pulse, systolic and diastolic pressures, as well as the differentiated rate of change (i.e., dP/dt), gross rate of change (ΔP/Δt) and mean or average of such pressure values are all or selectively developed by software algorithms and implemented in microprocessor based control circuitry. In one preferred embodiment, one or more of the values are utilized in software implemented algorithms to cause a pacemaker to pace the heart at a required rate to achieve a desired cardiac output. Alternatively, these left ventricular pressure related values may be employed to confirm the absence of mechanical pumping action of the heart which, in conjunction with other cardiac signals, confirm the existence of a tachyarrhythmia requiring anti-tachy pacing, cardioversion or defibrillation.

Claims

1. A method for controlling cardiac tachyarrhythmias by passing an electrical current through the heart which comprises:

disposing at least first and second electrodes in relation to the heart;

disposing a pressure transducer within the coronary sinus region of the heart adjacent to the left heart chambers;

detecting a signal proportional to the left heart chamber blood pressure by said pressure transducer and providing a first signal in response to detection of normal heart pumping and a second signal in response to detection of abnormal heart pumping, characteristic of hemodynamic insufficiency; and

supplying cardioversion energy to said heart in response to said second signal by application of stimulating pulses across said electrodes.

2. The method of claim 1 wherein said step of disposing at least first and second electrodes further comprises the step of providing at least one of said electrodes in said coronary sinus region in specific relation with said pressure transducer.

3. The method of claims 1 or 2 wherein said detecting step includes detecting a pressure proportional to left ventricular systolic blood pressure.

4. The method of claims 1 or 2 wherein said detecting step includes detecting a pressure proportional to left ventricular pulse pressure.

5. The method of claims 1 or 2 wherein said detecting step includes detecting a signal proportional to left ventricular peak to peak blood pressure.

6. The method of claims 1 or 2 wherein said detecting step includes detecting differentiated time rate of change (dP/dt) pressure values.

7. The method of claims 1 or 2 wherein said detecting step includes detecting time rate of change (Δ

P/Δ

t) pressure values.

8. The method of claim 1 wherein said step of disposing a pressure transducer in the coronary sinus or coronary vein region further comprises:

providing a pressure transducer in the distal portion of a lead body adapted to be inserted into the coronary sinus and from the coronary sinus into a coronary vein; and

transvenously advancing said distal portion of said lead body through the superior vena cava, the right atrium, the coronary sinus, and into said coronary vein.

9. The method of claim 8 further comprising the step of:

occluding the coronary vein proximal to the location of the pressure transducer when said pressure transducer is situated in the coronary vein.

10. The method of claim 9 wherein said step of occluding the coronary vein further comprises the step of:

providing an occluding member on said lead proximal to said pressure transducer.

11. Apparatus for controlling cardiac tachyarrhythmias by passing an electrical current through the heart which comprises:

means for disposing at least first and second electrodes in relation to the heart;

means for disposing a pressure transducer within the coronary sinus or coronary vein of the heart adjacent to the left heart chambers;

means for detecting a pressure proportional to left heart chamber blood pressure by said pressure transducer and providing a first signal in response to normal heart pumping and a second signal in response to abnormal heart pumping characteristic of hemodynamic insufficiency; and

means for supplying cardioverting energy to said heart in response to said second signal by application of stimulating pulses by means of said first and second electrodes.

12. The apparatus of claim 11 wherein said means for disposing at least first and second electrodes further comprises means for providing at least one of said electrodes in said coronary sinus region in specific relation with said pressure transducer.

13. The method of claims 11 or 12 wherein said means for detecting pressure includes means for detecting pressure proportional to left ventricular systolic blood pressure.

14. The method of claims 11 or 12 wherein said means for detecting pressure includes means for detecting pressure proportional to left ventricular pulse pressure.

15. The method of claims 11 or 12 wherein said means for detecting pressure includes means for detecting pressure proportional to left ventricular peak to peak blood pressure.

16. The method of claims 11 or 12 wherein said means for detecting pressure includes means for detecting differentiated time rate of change (dP/dt) pressure values.

17. The method of claims 11 or 12 wherein said means for detecting pressure includes means for detecting gross time rate of change (Δ

P/Δ

t) pressure values.

18. The apparatus of claim 11 wherein said means for disposing a pressure transducer in the coronary sinus or coronary vein region further comprises:

means for providing a pressure transducer in the distal portion of a lead body adapted to be inserted into the coronary sinus and from the coronary sinus into a coronary vein.

19. The apparatus of claim 18 further comprising:

means for occluding said coronary vein proximal to the location of the pressure transducer when said pressure transducer is situated in said coronary vein.

20. The apparatus of claim 19 wherein said means for occluding the coronary vein further comprises:

means for providing an occluding member on said lead proximal to said pressure transducer.

21. A method for regulating cardiac pacing rate in response to a patient'"'"'s left heart blood pressure which comprises:

disposing at least first and second electrodes in relation to the heart;

disposing a pressure transducer within the coronary sinus region of the heart adjacent to the left heart chambers;

detecting pressure signals by said pressure transducer;

providing a pacing rate control signal derived from said pressure signals; and

supplying pacing energy stimulation pulses to said electrodes at a rate established by said rate control signal.

22. The method of claim 21 wherein said step of disposing at least first and second electrodes further comprises the step of providing at least one of said electrodes in said coronary sinus region in specific relation with said pressure transducer.

23. The method of claim 21 wherein said step of disposing a pressure transducer in the coronary sinus region further comprises:

providing a pressure transducer in the distal portion of a lead body adapted to be inserted into the coronary sinus and from the coronary sinus into a coronary vein; and

transvenously advancing a distal portion of said lead body through the superior vena cava, the right atrium, the coronary sinus, and into a coronary vein.

24. The method of claim 21 or 23 wherein said step of detecting pressure signals includes detecting pressure signals proportional to left ventricular systolic block pressure.

25. The method of claims 21 or 23 wherein said step of detecting pressure signals includes detecting pressure signals proportional to left ventricular pulse pressure.

26. The method of claims 21 or 23 wherein said step of detecting pressure signals includes detecting left pressure signals proportional to ventricular peak to peak blood pressure.

27. The method of claims 21 or 23 wherein said step of detecting pressure signals includes detecting differentiated time rate of change (dP/dt) pressure values.

28. The method of claims 21 or 23 wherein said step of detecting pressure signals includes detecting time rate of change (Δ

P/Δ

t) pressure values.

29. The method of claim 21 further comprising the step of:

occluding said coronary vein proximal to the location of said pressure transducer when said pressure transducer is situated in said coronary vein.

30. The method of claim 29 wherein said step of occluding said coronary vein further comprises the step of:

providing an occluding member on said lead proximal to said pressure transducer.

31. Apparatus for regulating cardiac pacing rate in response to a patient'"'"'s left heart blood pressure which comprises:

means for disposing at least first and second electrodes in relation to the heart;

means for disposing a pressure transducer within the coronary sinus region of the heart adjacent to the left heart chambers;

means for detecting pressure signals by said pressure transducer and providing a pacing rate control signal derived from the pressure signal; and

means for supplying pacing energy stimulation pulses to said electrodes at a rate established by said rate control signal.

32. The apparatus of claim 31 wherein said means for disposing at least first and second electrodes further comprises means for providing at least one of said electrodes in said coronary sinus region in specific relation with said pressure transducer.

33. The apparatus of claim 32 wherein the means for disposing a pressure transducer in the coronary sinus region further comprises:

means for providing a pressure transducer in the distal portion of a lead body adapted to be inserted into the coronary sinus and from the coronary sinus into a coronary vein.

34. The apparatus of claims 31 or 33 wherein said means for detecting pressure signals includes means for detecting signals proportional to left ventricular systolic blood pressure.

35. The apparatus of claims 31 or 33 wherein said means for detecting pressure signals includes means for detecting signals proportional to left ventricular pulse pressure.

36. The apparatus of claims 31 or 33 wherein said means for detecting pressure signals includes means for detecting signals proportional to left ventricular peak to peak blood pressure.

37. The apparatus of claims 31 or 33 wherein said means for detecting pressure signals includes means for detecting differentiated time rate of change (dP/dt) pressure values.

38. The apparatus of claims 31 or 33 wherein said means for detecting pressure signals includes means for detecting gross time rate of change (Δ

P/Δ

t) pressure values.

39. The apparatus of claim 31 further comprising:

means for occluding said coronary vein proximal to location of said pressure transducer when said pressure transducer is situated in said coronary vein.

40. The apparatus of claim 39 wherein said means for occluding said coronary vein further comprises:

means for providing an occluding member on said lead proximal to the pressure transducer.