Sensor device

• US 5,130,009 A
• Filed: 01/24/1990
• Issued: 07/14/1992
• Est. Priority Date: 01/27/1989
• Status: Expired due to Term

• Current Assignee: Avl Medical Instruments AG (Roche Holding AG)
• Original Assignee: Avl Medical Instruments AG (Roche Holding AG)
• Inventors: Skrabal, Falko, Kontschieder, Heinz, List, Helmut, Marsoner, Hermann
• Primary Examiner(s): Tung, T.
• Application Number:
  US07/469,214
• Time in Patent Office: 902 Days
• Field of Search: 204/403, 204/415, 204/416-420, 204/435, 204/153.12, 204/153.17, 204/412, 204/409, 435/817, 436/806
• US Class Current: 204/403.11
• CPC Class Codes: C12Q 1/006 for glucose
• CPC Class Codes: G01N 27/3272 Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels optical biosensors G01N33/52
• CPC Class Codes: Y10S 435/817 Enzyme or microbe electrode
• CPC Class Codes: Y10S 436/806 Electrical property or magnetic property

Abstract

In order to produce a small-volume flow measuring cell with good flow characteristics in a sensor device for determining the concentration of a substrate in a sample medium, comprising an enzyme electrode which is covered by a membrane and a reference electrode, both of which are in contact with the measuring cell, the proposal is put forward that the reference electrode be located outside of the membrane cover of the enzyme electrode and that the maximum extension of the flow measuring cell normal to the flow direction of the sample medium essentially be the same as the diameter of the sensitive layer of the enzyme electrode.

Claims

1. A sensor device for determining the concentration of a substrate in a sample medium, said device comprising a plurality of electrodes and a membrane, only one of said plurality of electrodes being covered by said membrane, said one electrode being an amperometric, enzyme anode, and another of said plurality of electrodes being a reference electrode positioned outside the membrane cover of said enzyme anode, both said anode and reference electrodes being in contact with a flow measuring cell, said cell being a hollow channel located in a housing which comprises two housing parts, said channel defined by opposite faces of the two housing parts, wherein the maximum extension of said flow measuring cell normal to the flow direction of said sample medium is essentially the same as the diameter of a sensitive layer of said amperometric enzyme anode, and wherein one of said faces contains said sensitive layer of said amperometric enzyme anode and the other of said faces contains said reference electrode.

2. A sensor device according to claim 1, wherein said reference electrode is an Ag-electrode.

3. A sensor device according to claim 1, wherein said reference electrode also constitutes a part of an electrode arrangement for impedance measurement and a further electrode of said plurality of electrodes being a corresponding complementary electrode of said electrode arrangement, said further electrode being located in said face containing said sensitive layer of said amperometric enzyme anode and being positioned outside the membrane cover.

4. A sensor device according to claim 3, wherein said complementary electrode of said electrode arrangement for impedance measurement is formed by said anode of said amperometric enzyme electrode.

5. A sensor device according to claim 4, wherein said amperometric enzyme anode is configured as a glucose sensor.

6. A sensor device according to claim 3, wherein a temperature sensor is inserted into a bore of said housing of said flow measuring cell, said bore being coaxial with and opposite of said complementary electrode.

7. A sensor device according to claim 6, wherein said temperature sensor is an NTC resistor.

8. A sensor device according to claim 1, wherein said amperometric enzyme anode is configured as a glucose sensor.

9. A sensor device according to claim 6, wherein said amperometric enzyme anode is configured as a glucose sensor.