Hydrolytically degradable hydrophilic gels and the method for preparation thereof using N,O-dimethacryloylhydroxylamine as a cross-linking agent

• US 5,130,479 A
• Filed: 12/10/1991
• Issued: 07/14/1992
• Est. Priority Date: 12/20/1989
• Status: Expired due to Fees

• Current Assignee: Ceskoslovenska akademie ved
• Original Assignee: Ceskoslovenska akademie ved
• Inventors: Ulbrich, Karel, Subr, Vladimir
• Primary Examiner(s): Schofer, Joseph L.
• Assistant Examiner(s): NAGUMO, MARK
• Application Number:
  US07/805,464
• Time in Patent Office: 217 Days
• Field of Search: 560/312, 564/204, 562/874, 562/887
• US Class Current: 562/874
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 9/2027 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: C07C 259/06 having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
• CPC Class Codes: C08F 220/58 containing oxygen in addition to the carbonamido oxygen , e.g. N-methylolacrylamide, N-(meth)acryloylmorpholine
• CPC Class Codes: Y10S 524/916 Hydrogel compositions

Abstract

The solution pertains to hydrolytically degradable hydrophilic gels consisting of the individual chains of hydrophilic polymer interconnected with crosslinks containing the structure unit ##STR1## The method for preparation of the hydrolytically degradable gels consists in subjecting hydrophilic monomers or their mixture to the radical polymerization or copolymerization, or to copolymerization with hydrophobic monomers, in the presence of a new compound--N,O-dimethacryloylhydroxylamine--as a crosslinking agent, and, if desired, in the presence of a solvent, whereas the amount of hydrophilic monomers is 50 to 99.8 molar percent related to all monomers present.

Claims

1. N,O-dimethacryloylhydroxylamine.