Method and apparatus for monitoring neuromuscular blockage

• US 5,131,401 A
• Filed: 09/10/1990
• Issued: 07/21/1992
• Est. Priority Date: 09/10/1990
• Status: Expired due to Fees

• Current Assignee: Axon Medical, Inc.
• Original Assignee: Axon Medical, Inc.
• Inventors: Orr, Joseph A., Westenskow, Dwayne R.
• Primary Examiner(s): Pellegrino, Stephen C.
• Assistant Examiner(s): Shumaker, Steven J.
• Application Number:
  US07/580,294
• Time in Patent Office: 680 Days
• Field of Search: 128/662.03, 128/670, 128/672, 128/675, 128/680, 128/686, 128/687, 128/689, 128/690, 128/691, 128/714, 128/721, 128/722, 128/733, 128/741, 128/774, 128/782, 128/82.1, 310/311, 310/800
• US Class Current: 600/554
• CPC Class Codes: A61B 2562/0219 Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
• CPC Class Codes: A61B 5/1106 to assess neuromuscular blockade, e.g. to estimate depth of anaesthesia
• CPC Class Codes: A61B 5/6825 Hand
• CPC Class Codes: A61B 5/7207 of noise induced by motion artifacts
• CPC Class Codes: A61B 5/7217 of noise originating from a therapeutic or surgical apparatus, e.g. from a pacemaker

Abstract

The present invention comprises a method and apparatus for monitoring neuromuscular blockage, and more specifically contemplates the quantitative measurement of movement of the skin of a patient overlying an electrically simulated skeletal muscle as an indicia of such blockage. The preferred embodiment of the apparatus of the present invention includes a piezoelectric film affixed over the patient'"'"'s skin, the film generating an electric current in proportion to the magnitude of skin movement.

Claims

1. An apparatus for monitoring neuromuscular blockage in a patient, comprising:

means for providing electrical stimulation to a peripheral nerve of said patient; and

means for measuring the degree of response evoked in a skeletal muscle of said patient by said electrical stimulation of said peripheral nerve, said measuring means including;

a flexible film of piezoelectric material for generating an electrical signal generally proportional to the degree of deflection thereof;

nonconductive material substantially encapsulating said piezoelectric film;

thin, flexible pad means for supporting said substantially encapsulated piezoelectric film, said pad means having one side secured to said piezoelectric film and another side for application to the skin of the patient; and

means for securing said thin, flexible pad means over the skin of said patient in overlying relationship to said skeletal muscle.

2. The apparatus of claim 1, wherein said means for securing comprises an adhesive.

3. The apparatus of claim 2, wherein said adhesive is disposed over substantially the entire said another side of said pad means.

4. The apparatus of claim 1, wherein said measuring means further includes first and second lead wires conductively attached to said piezoelectric film.

5. The apparatus of claim 4, wherein said piezoelectric film includes a primary bending axis, and said first and second lead wires are attached to said film at locations removed therefrom.

6. The apparatus of claim 4, further including contact pads on said piezoelectric film, by which said first and second lead wires are conductively attached thereto.

7. The apparatus of claim 4, wherein said electrically nonconductive material defines a leg extending peripherally beyond said piezoelectric film, and said lead wires extend from said piezoelectric film through said leg and beyond said nonconductive material.

8. An apparatus for monitoring neuromuscular blockage in a patient, comprising:

means for providing electrical stimulation to a peripheral nerve of said patient; and

means for measuring the degree of response evoked in a skeletal muscle of said patient by said electrical stimulation of said peripheral nerve, said measuring means including;

an electrical power source;

flexible strain gauge means in communication with said electrical power source for varying the electrical resistance to power from said power source in response to the degree of deflection of said flexible strain gauge means;

nonconductive material encapsulating said flexible strain gauge means;

thin, flexible pad means for supporting said flexible strain gauge means, said pad means having one side secured to said strain gauge means and another side for application to the skin of the patient; and

means for securing said thin, flexible pad means over the skin of said patient in overlying relationship to said skeletal muscle.

9. The apparatus of claim 8, wherein said means for securing comprises adhesive.

10. An apparatus for monitoring neuromuscular blockage in a patient, comprising:

means for providing electrical stimulation to a peripheral nerve of said patient; and

means for measuring the degree of response evoked in a skeletal muscle of said patient by said electrical stimulation of said peripheral nerve, said measuring means including;

a flexible, variable capacitor comprising two flexible, substantially parallel, thin conductive members having a flexible dielectric substrate disposed therein;

first and second electrical conductors each communicating with one of said members and extending to an electrical power source;

thin, flexible pad means for supporting said flexible, variable capacitor, said pad means having one side secured to said variable capacitor and another side for application to the skin of the patient; and

means for securing said thin, flexible pad means over the skin of said patient in overlying relationship to said skeletal muscle.

11. The apparatus of claim 10, wherein said means for securing comprises adhesive.

12. An apparatus for monitoring neuromuscular blockage in a patient, comprising:

means for providing electrical simulation to a peripheral nerve of said patient; and

means for measuring the degree of response evoked in a skeletal muscle of said patient by said electrical stimulation of said peripheral nerve, said measuring means including;

a substantially planar, internally resiliently supported, flexible bladder containing a substantially compressible fluid therein,

means in communication with said fluid for sensing pressure or density changes therein and generating a signal generally proportional to the magnitude of said changes;

thin, flexible pad means for supporting said flexible, bladder, said pad means having one side secured to said flexible bladder and another side for application to the skin of the patient; and

means for securing said thin, flexible pad means over the skin of said patient in overlying relationship to said skeletal muscle.

13. The apparatus of claim 12, wherein said means for securing comprises adhesive.

14. A method of measuring neuromuscular blockage in a patient, comprising:

securing a skin movement sensor in direct contact with the skin of said patient overlying a skeletal muscle;

measuring background movement of said skin with said skin movement sensor and quantifying said background movement as an electrical parameter;

electrically stimulating a peripheral nerve of said patient associated with said skeletal muscle to evoke a response therefrom;

measuring movement of said skin subsequent to said electrical nerve stimulation and during said evoked muscle response with said skin movement sensor, and quantifying said skin movement during said evoked skeletal muscle response as an electrical parameter; and

subtracting said quantified background movement of said skin from said quantified skin movement measured during said evoked skeletal muscle response.

15. The method of claim 14, further including the step of waiting for electromagnetic effects resulting from said electrical stimulation to dissipate from said skin movement sensor before said step of measuring said skin movement during said evoked skeletal muscle response.

16. The method of claim 14, further including graphically representing the magnitude of said quantified skin movement during said evoked skeletal muscle response after subtraction of said quantified background skin movement therefrom.

17. The method of claim 16, further including the step of identifying artifact in said quantified skin movement during said evoked skeletal muscle response after subtraction of said background skin movement therefrom and removing said artifact therefrom prior to said step of graphically representing.