Method for obtaining blood using iontophoresis

• US 5,131,403 A
• Filed: 06/05/1991
• Issued: 07/21/1992
• Est. Priority Date: 06/05/1991
• Status: Expired due to Term

• Current Assignee: Vyteris, Inc.
• Original Assignee: Becton, Dickinson & Co
• Inventors: Haynes, John L.
• Primary Examiner(s): Hindenburg, Max
• Assistant Examiner(s): Tucker, Guy V.
• Application Number:
  US07/710,420
• Time in Patent Office: 412 Days
• Field of Search: 128/760, 128/762, 128/763, 128/765, 128/768, 128/770, 604/20, 604/21, 604/51
• US Class Current: 600/573
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/153 Devices specially adapted for taking samples of venous or arterial blood, e.g. with syringes
• CPC Class Codes: A61B 5/154 Devices using pre-evacuated means
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

The present invention provides a method for obtaining blood from a patient which comprises:

(a) iontophoretic delivery of a bacteriocidal effective amount of a bacteriocide through the patient'"'"'s skin, and

(b) obtaining blood through the skin at the site of the iontophoretic delivery.

The invention is particularly advantages in reducing the effects of contaminants responsible for large numbers of false positives. This advantageous is beneficial not only to a patient who benefits from an accurate diagnosis, but is also beneficial economically by eliminating unnecessary hospital stays, testing, and consulting.

Claims

1. A method for obtaining blood from a patient which comprises:

(a) iontophoretic delivery of a bacteriocidal effective amount of a bacteriocide through the patient'"'"'s skin, and

(b) obtaining blood through the skin at the site of said iontophoretic delivery.

2. The method of claim 1 in which the obtaining step is performed by the blood collection means selected from the group consisting of test tubes, capillary tubes, needle and syringe, and evacuated collection means.

3. The method of claim 2 in which the means to collect blood is by needle and syringe.

4. The method of claim 2 in which the means to collect blood is by evacuated collection means.

5. The method of claim 1 in which the site of said iontophoretic delivery is pretreated with a composition selected from the group consisting of enhancers and anesthetics.

6. The method of claim 5 in which the composition is an enhancer.

7. The method of claim 5 in which the composition is an anesthetic.

8. The method of claim 1 in which the bacteriocide is selected from the group consisting of anesthetics, silver, iodine compounds, iodophors, quarternary ammonium compounds, and acetyl salicylic acid.

9. The method of claim 8 in which the bacteriocide is an anesthetic.

10. The method of claim 9 in which the anesthetic is selected from the group consisting of benzocaine, procaine, lidocaine, ropivacaine, etidocaine, bupivocaine, tetracaine, prilocaine, salt forms, and mixtures thereof.

11. The method of claim 10 in which the anesthetic is lidocaine.

12. The method of claim 10 in which the anesthetic is procaine.

13. The method of claim 10 in which the anesthetic is ropivacaine.

14. The method of claim 8 in which the bacteriocide is silver.