Antiviral glove

• US 5,133,090 A
• Filed: 07/18/1990
• Issued: 07/28/1992
• Est. Priority Date: 02/11/1988
• Status: Expired due to Fees

• Current Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Original Assignee: Trustees Of Columbia University In The City Of New York (Columbia University)
• Inventors: Modak, Shanta M., Sampath, Lester
• Primary Examiner(s): Schroeder, Werner H.
• Assistant Examiner(s): CURRENT, SARA
• Application Number:
  US07/555,093
• Time in Patent Office: 741 Days
• Field of Search: 2/161 R, 2/169, 2/167, 2/168, 2/159, 2/163, 2/243 A, 2/21, 128/918, 128/917, 604/292, 523/122
• US Class Current: 2/168
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 25/24 containing ingredients to enhance the sticking of the active ingredients
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A41D 19/0055 Plastic or rubber gloves
• CPC Class Codes: A41D 31/305 using layered materials
• CPC Class Codes: A61B 42/00 Surgical gloves; Finger-stalls specially adapted for surgery; Devices for handling or treatment thereof
• CPC Class Codes: A61B 42/10 Surgical gloves
• CPC Class Codes: A61L 2/16 using chemical substances
• CPC Class Codes: A61L 2300/206 Biguanides, e.g. chlorohexidine
• CPC Class Codes: A61L 2300/408 Virucides, spermicides
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 31/12 Antivirals

Abstract

An antiviral surgical or examination glove is obtained by blocking adsorption sites for the antiinfective agent which may exist in the lubricating agent, e.g., cross-linked corn starch, or in the material of the glove itself. The glove of the invention comprises an elastomeric hand-shaped body having interior and exterior surfaces and an inner coating disposed on the interior surface of the elastomeric body. The inner coating comprises (a) an antiinfective agent selected from the group consisting of chlorhexidine and pharmaceutically acceptable salts of chlorhexidine and (b) a lubricating agent which does not significantly adsorb the antiinfective agent. The inner coating is effective to deliver an antivirally effective amount of the antiinfective agent within ten minutes of exposure to a liquid.

Claims

1. An antiviral glove consisting essentially of an elastomeric hand-shaped body having interior and exterior surfaces and an inner coating disposed on the interior surface of the elastomeric body, wherein the inner coating comprises (a) an antiinfective agent selected from the group consisting of chlorhexidine and pharmaceutically acceptable salts of chlorhexidine and (b) a lubricating agent which does not significantly adsorb the antiinfective agent, said inner coating being effective to deliver an antivirally effective amount of the antiinfective agent within ten minutes of exposure to a liquid.

2. An antiviral glove according to claim 1, wherein the delivery of antiinfective agent from the inner coating is substantially complete within ten minutes of exposure to liquid.

3. An antiviral glove according to claim 1, wherein the lubricating agent is corn starch modified with didecyldimethylammonium chloride.

4. An antiviral glove according to claim 3, wherein the elastomeric body is formed from a natural rubber latex.

5. An antiviral glove according to claim 4, wherein the natural rubber latex is modified to saturate binding sites for the antiinfective agent in the latex.

6. An antiviral glove according to claim 5, wherein the latex is saturated with a material selected from the group selected from metal ions, organic acids and cationic surfactants.

7. An antiviral glove according to claim 1, wherein the inner coating further comprises a biomedically acceptable polymer.

8. An antiviral glove according to claim 7, wherein the polymer is selected from the group consisting of silicones and polyurethanes.

9. An antiviral glove according to claim 1, wherein the elastomeric body is formed from a natural rubber latex.

10. An antiviral glove according to claim 9, wherein the natural rubber latex is modified to saturate binding sites for the antiinfective agent in the latex.

11. An antiviral glove according to claim 10, wherein the latex is saturated with a material selected from the group consisting of metal ions, organic acids and cationic surfactants.

12. An antiviral glove according to claim 1, wherein the lubricating agent is zinc oxide.

13. An antiviral glove according to claim 1, wherein the glove contains from 3.0 to 6.5 mg of releasable antiinfective agent.