Method of providing a substrate with a layer comprising a polyvinyl based hydrogel and a biochemically active material
First Claim
1. Method of providing a substrate with a layer comprising a polyvinyl based hydrogel and a biochemically active material by photolithography, comprising combining a preformed first aqueous solution of a photosensitive hydrogel forming polymer and a polyazonium compound as a first cross linking agent with a preformed second aqueous solution of a biochemically active material and glutardialdehyde as a second cross linking agent to form a combination aqueous solution of the hydrogel forming polymer, the biochemically active material and the combination of the polyazonium compound and glutardialdehyde as cross linking agents, coating the substrate by centrifugal force with said combination aqueous solution, drying the coating, exposing the coated substrate through a photomask to ultraviolet radiation and developing the exposed coating by dissolving the non-irradiated parts to form a negative image.
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Accused Products
Abstract
Disclosed is a method of providing a substrate with a layer comprising a polyvinyl base hydrogel and a biochemically active material by photolithograhy, comprising coating the substrate by centrifugal force with an aqueous solution of a photosensitive hydrogel forming polymer, a crosslinking agent and a biochemically active material, drying said coating, exposing the coated substrate through a photomask to ultraviolet radiation and developing said exposed coating, which is characterized by applying to the substrate an aqueous solution comprising as the cross-linking agent a polyazonium compound and glutardialdehyde. Because of this specific combination of cross-linking agents superior properties with respect to the binding of the biochemically active material are obtained.
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Citations
19 Claims
- 1. Method of providing a substrate with a layer comprising a polyvinyl based hydrogel and a biochemically active material by photolithography, comprising combining a preformed first aqueous solution of a photosensitive hydrogel forming polymer and a polyazonium compound as a first cross linking agent with a preformed second aqueous solution of a biochemically active material and glutardialdehyde as a second cross linking agent to form a combination aqueous solution of the hydrogel forming polymer, the biochemically active material and the combination of the polyazonium compound and glutardialdehyde as cross linking agents, coating the substrate by centrifugal force with said combination aqueous solution, drying the coating, exposing the coated substrate through a photomask to ultraviolet radiation and developing the exposed coating by dissolving the non-irradiated parts to form a negative image.
Specification