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Improved probes using nucleosides containing 3-dezauracil analogs

  • US 5,134,066 A
  • Filed: 08/29/1989
  • Issued: 07/28/1992
  • Est. Priority Date: 08/29/1989
  • Status: Expired due to Term
First Claim
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1. A single-stranded nucleic acid probe which comprises a nucleoside residue of the formula:

  • ##STR76## in which R1 and R2 independently are C1 -C5 alkyl, C2 -C5 alkenyl, halo or hydrogen, R3 is hydrogen, hydroxy, C6-14 aryloxy or C1 -C5 alkoxy and in which the nucleoside residue is at least five nucleosides from both ends of the probe and said probe is capable of hybridizing with a target nucleic acid and said hybridizing is mediated by the presence of nondeazauracil nucleotide which are contained within said probe residues.

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