Transdermal drug delivery device
First Claim
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1. A transdermal device suitable for long term administration of a drug substance comprising:
- a housing;
a complete electrical circuit having a first electrode detachably mounted within a recess in said housing, said first electrode having a first surface adapted for contact with human skin and through which the drug substance contained in the first electrode may pass to the skin under the influence of an iontophoretic or electro-osmotic force and a second surface remote from said skin-contacting surface which is electrically conducting and which is adapted for contact with an electrical source in said housing such that the first electrode can be discarded and replaced by a new electrode when the drug supply substance is exhausted, said first electrode having a surface area adapted to be in contact with the skin when in use, said drug substance being dissolved or dispersed in a hydrophilic medium defining said first electrode, and said second surface of said first electrode is drug impermeable, a means for adjusting the current, means for indicating the current is in the required range for correct administration, and a second electrode which is optionally detachable for completing said electrical circuit; and
a non-adhesive means for securing said device to the skin.
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Abstract
A transdermal device having a detachably mounted electrode with a first surface adapted for contact with human skin and through which a drug substance contained in the electrode passes to the skin under the influence of an iontophoretic or electro-osmotic force and a second surface which is electrically conducting, the electrode has a surface area in contact with the skin, in use, in the range 0.1 to 30 cm2 and a drug dissolved or dispersed in a hydrophilic medium at a concentration in the range 0.1 to 15% (w/v) based on the hydrophilic medium.
204 Citations
16 Claims
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1. A transdermal device suitable for long term administration of a drug substance comprising:
- a housing;
a complete electrical circuit having a first electrode detachably mounted within a recess in said housing, said first electrode having a first surface adapted for contact with human skin and through which the drug substance contained in the first electrode may pass to the skin under the influence of an iontophoretic or electro-osmotic force and a second surface remote from said skin-contacting surface which is electrically conducting and which is adapted for contact with an electrical source in said housing such that the first electrode can be discarded and replaced by a new electrode when the drug supply substance is exhausted, said first electrode having a surface area adapted to be in contact with the skin when in use, said drug substance being dissolved or dispersed in a hydrophilic medium defining said first electrode, and said second surface of said first electrode is drug impermeable, a means for adjusting the current, means for indicating the current is in the required range for correct administration, and a second electrode which is optionally detachable for completing said electrical circuit; and
a non-adhesive means for securing said device to the skin. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
- a housing;
- 13. A transdermal device comprising a housing first electrode detachably mounted to said housing and an electrical source within said housing wherein said housing is mounted in a strap or bracelet for attachment to a limb of a body, said first electrode having a fist surface with a surface area adapted for contact with human skin when in use, a drug substance dissolved or dispersed in a hydrophilic medium defining said first electrode which can pass to the skin under the influence of an iontophoretic or electroosmotic force created by said electrical source, and a second surface remote from said first surface which is drug impermeable, electrically conducting and an integral part of said first electrode, said second surface further being adapted for contact with said electrical source, and a second electrode in said strap or bracelet for connection to said electrical source and adapted to be situated at a different site on the skin to said first electrode.
Specification