Delivery system for administering agent to ruminants and swine

• US 5,135,523 A
• Filed: 04/20/1990
• Issued: 08/04/1992
• Est. Priority Date: 12/13/1988
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Magruder, Judy A., Eckenhoff, James B., Wright, Jeremy C., Peery, John R., Cortese, Richard
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): Polutta, Mark O.
• Application Number:
  US07/513,363
• Time in Patent Office: 837 Days
• Field of Search: 604/890.1, 604/891.1, 604/891.2, 604/27, 604/48, 604/49, 424/438, 424/473
• US Class Current: 604/892.1
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

A delivery system is disclosed for delivering a beneficial agent to an animal. The delivery system comprises a wall that surrounds a lumen, said wall comprising a composition that limits the passage of fluid into the system and a composition that permits the passage of fluid into the system. The lumen comprises a beneficial agent and an expandable member. The delivery system comprises an exit means for delivering the beneficial agent.

Claims

1. A delivery system for delivering a beneficial agent to a fluid environment of use, wherein the delivery system comprises:

(a) two sections assembled together at their receiving ends to form the delivery system;

wherein

(b) one section comprises a first wall that is substantially impervious to the passage of fluid and surrounds a first reservoir area;

(c) one section comprises a second wall that is substantially pervious to the passage of fluid and surrounds a second reservoir area;

(d) exit means in the first wall in the delivery system for delivering the beneficial agent from the first reservoir area to the environment of use; and

wherein the delivery system comprises;

(e) means in the second reservoir area surrounded by the second wall pervious to fluid for pushing the beneficial agent from the reservoir; and

,

(f) a beneficial agent in the first reservoir area surrounded by the first wall substantially impervious to the passage of fluid for protecting a fluid-sensitive beneficial agent while in the first reservoir from fluid present in the environment of use.

2. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the two-pieces are fused together.

3. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the two-pieces are assembled by an adhesive.

4. The delivery system for delivering the beneficial agent to an environment of use according to claim 1, wherein the two pieces assembled together are in telescopic engagement.