Variation in cardiac chamber volume or pressure as a controlling parameter

• US 5,137,019 A
• Filed: 03/01/1991
• Issued: 08/11/1992
• Est. Priority Date: 03/08/1990
• Status: Expired due to Term

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Salo, Rodney W., Pederson, Brian D.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Getzow, Scott M.
• Application Number:
  US07/664,461
• Time in Patent Office: 529 Days
• Field of Search: 128/734, 128/419 PG
• US Class Current: 607/20
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: G06F 2218/00 Aspects of pattern recognition specially adapted for signal processing

Abstract

A rate adaptive cardiac pacer is described in which the impedance versus time information derived using impedance plethysmography or the pressure versus time information derived from a pressure transducer in a ventricular chamber is signal processed to recover a modulating envelope due to volume or pressure changes occasioned by respiratory activity. Either or both of the respiratory interval or respiratory depth may be combined in an appropriate rate control algorithm with other parameters also derived from the impedance versus time signal to develop a rate control signal for an implanted pacer.

Claims

1. A rate adaptive pacer comprising:

implantable pulse generator means for normally producing cardiac stimulating pulses at a predetermined lower rate;

sensing means for sensing impedance in the blood in a selected cardiac chamber;

means for producing a time varying impedance signal proportional to the intracardiac impedance measured in the selected cardiac chamber due to the beating action of the heart;

means for extracting from the time varying impedance signal a modulation signal due to volume changes;

means for relating the modulation signal to and extracting quantitative information therefrom with respect to the respiratory activity of the patient in whom the pulse generator means is implanted, the respiratory activity information including that relating both to the respiration interval (I_RESP) and the respiration depth (D_RESP); and

means for producing a rate control signal from the modulation signal which, when applied to the pulse generator means, changes the rate at which the stimulating pulses are produced from the predetermined lower rate to a higher rate, the interval between the cardiac stimulating pulses is made to vary in accordance with the algorithm;

##EQU4## where a and b are constants, I_RESP is the respiratory interval and D_RESP is the respiratory depth and ##EQU5## are base values relating to values obtained with the patient at rest.

2. A rate adaptive pacer comprising:

implantable pulse generator means for normally producing cardiac stimulating pulses at a predetermined lower rate;

sensing means for sensing impedance in the blood in a selected cardiac chamber;

means for producing a time varying impedance signal proportional to the intracardiac impedance measured in the selected cardiac chamber due to the beating action of the heart;

means for extracting from the time varying impedance signal a modulation signal due to volume changes;

means for relating the modulation signal to and extracting quantitative information therefrom with respect to the respiratory activity of the patient in whom the pulse generator means is implanted, the respiratory activity information including that relating both to the respiration interval (I_RESP) and the respiration depth (D_RESP); and

means for producing a rate control signal from the modulation signal which, when applied to the pulse generator means, changes the rate at which the stimulating pulses are produced from the predetermined lower rate to a higher rate, the interval between the cardiac stimulating pulses is made to vary in accordance with the algorithm;

##EQU6## where a, b, c, d, e are numerical constants and ##EQU7## are base values corresponding to values obtained with the patient at rest.

3. The rate adaptive pacer as in claim 2 wherein the numerical constants are programmable.

4. The rate adaptive pacer as in claim 2 wherein the numerical constants are fixed.

5. A rate adaptive pacer comprising:

implantable pulse generator means for normally producing cardiac stimulating pulses at a predetermined lower rate;

sensing means for sensing impedance in the blood in a selected cardiac chamber;

means for producing a time varying impedance signal proportional to the intracardiac impedance measured in the selected cardiac chamber due to the beating action of the heart;

means for extracting from the time varying impedance signal a modulation signal due to volume changes;

means for relating the modulation signal to and extracting quantitative information therefrom with respect to the respiratory activity of the patient in whom the pulse generator means is implanted, the respiratory activity information including that relating both tot he respiration interval (I_RESP) and the respiration depth (D_RESP); and

means for producing a rate control signal from the modulation signal which, when applied to the pulse generator means, changes the rate at which the stimulating pulses are produced from the predetermined lower rate to a higher rate, the interval between the cardiac stimulating pulses is made to vary in accordance with the algorithm;

##EQU8## where a, b c, and d are numerical constants and SV_base, PEI_base, dZ/dt_base, I_RESP and D_RESP are base values relating to values obtained with the patient at rest.

6. A rate adaptive pacer comprising:

implantable pulse generator means for normally producing cardiac stimulating pulses at a predetermined lower rate;

sensor means for sensing the pressure in a selected cardiac chamber;

means for producing a time varying signal proportional to the pressure measured in the selected cardiac chamber due to the beating action of the heart;

means for extracting from the time varying pressure signal a modulation signal due to pressure changes;

means for relating the modulation signal to and extracting quantitative information therefrom relating to the respiratory activity of the patient in whom the pulse generator means is implanted, the respiratory activity information including that related to the respiration interval (I_RESP) and the respiration depth (D_RESP); and

means for producing a rate control signal from the modulation signal which, when applied to the pulse generator means, changes the interval between the stimulating pulses produced from said predetermined lower rate to a higher rate in accordance with a known relationship between I_RESP and D_RESP expressed as the following empirical algebraic function;

##EQU9## where a and b are constants, I_RESP is the respiratory interval and D_RESP is the respiratory depth and I_RESP and D_RESP are baseline values relating to values obtained with the patient at rest.

7. A rate adaptive pacer comprising:

implantable pulse generator means for normally producing cardiac stimulating pulses at a predetermined lower rate;

sensor means for sensing the pressure in a selected cardiac chamber;

means for producing a time varying signal proportional to the pressure measured in the selected cardiac chamber due to the beating action of the heart;

means for extracting from the time varying pressure signal a modulation signal due to pressure changes;

means for relating the modulation signal to and extracting quantitative information therefrom relating to the respiratory activity of the patient in whom the pulse generator means is implanted, the respiratory activity information including that related to the respiration interval (I_RESP) and the respiration depth (D_RESP); and

means for producing a rate control signal from the modulation signal which, when applied to the pulse generator means, changes the interval between the stimulating pulses produced from said predetermined lower rate to a higher rate in accordance with a known relationship between I_RESP and D_RESP expressed as the following empirical algebraic function;

##EQU10## where D_RESP and I_RESP are baseline values corresponding to values obtained with the patient at rest.

8. A rate adaptive pacer comprising:

implantable pulse generator means for normally producing cardiac stimulating pulses at a predetermined lower rate;

sensor means for sensing the pressure in a selected cardiac chamber;

means for producing a time varying signal proportional to the pressure measured in the selected cardiac chamber due to the beating action of the heart;

means for extracting from the time varying pressure signal a modulation signal due to pressure changes;

means for relating the modulation signal to and extracting quantitative information therefrom relating to the respiratory activity of the patient in whom the pulse generator means is implanted, the respiratory activity information including that related to the respiration interval (I_RESP) and the respiration depth (D_RESP); and

means for producing a rate control signal from the modulation signal which, when applied to the pulse generator means, changes the interval between the stimulating pulses produced from said predetermined lower rate to a higher rate in accordance with a known relationship between I_RESP and D_RESP expressed as the following empirical algebraic function;

##EQU11## where a, b, c, d, and e are numerical constants and Δ

P_BASE, PEI_BASE, (dP/dt)P_BASE, I_RESP, and D_RESP are baseline values corresponding to values obtained with the patient at rest.

9. The rate adaptive pacer as in claim 8 wherein the numerical constants are programmable.

10. The rate adaptive pacer as in claim 8 wherein the numerical constants are fixed.

11. A rate adaptive pacer comprising:

implantable pulse generator means for normally producing cardiac stimulating pulses at a predetermined lower rate;

sensor means for sensing the pressure in a selected cardiac chamber;

means for producing a time varying signal proportional to the pressure measured in the selected cardiac chamber due to the beating action of the heart;

means for extracting from the time varying pressure signal a modulation signal due to pressure changes;

means for relating the modulation signal to and extracting quantitative information therefrom relating to the respiratory activity of the patient in whom the pulse generator means is implanted, the respiratory activity information including that related to the respiration interval (I_RESP) and the respiration depth (D_RESP); and

means for producing a rate control signal from the modulation signal which, when applied to the pulse generator means, changes the interval between the stimulating pulses produced from said predetermined lower rate to a higher rate in accordance with a known relationship between I_RESP and D_RESP expressed as the following empirical algebraic function;

##EQU12## where a, b, c, and d are numerical constants, ##EQU13## are base values relating to values obtained with the patient at rest.