Ophthalmic article

• US 5,137,728 A
• Filed: 12/22/1988
• Issued: 08/11/1992
• Est. Priority Date: 03/01/1988
• Status: Expired due to Fees

• Current Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Original Assignee: Bausch & Lomb Incorporated (Bausch Health Cos., Inc.)
• Inventors: Bawa, Rajan
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Spear, James M.
• Application Number:
  US07/288,398
• Time in Patent Office: 1,328 Days
• Field of Search: 424/427, 424/429, 424/428
• US Class Current: 424/427
• CPC Class Codes: A61F 9/0017 implantable in, or in contact with, the eye, e.g. ocular inserts
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants

Abstract

An ocular insert for insertion into the cul de sac of the eye which is a substantially circular disc having a concave posterior surface and a convex anterior surface with a radius of curvature less than that of the sclera and a center thickness of less than about 1.5 mm.

Claims

1. An ocular insert for use behind an eyelid, comprising a substantially circular disc having a concave posterior surface and a convex anterior surface wherein the radius of curvature of said posterior surface is less than the radius of curvature of the sclera of the eye, the center thickness of said insert is less than about 1.5mm and the ratio of the radius of curvature of said posterior surface to the radius of curvature of the sclera is less than about 0.8mm wherein incorporated in said ocular insert a medicinal agent is incorporated therein.

3. The insert of claim 1 wherein the radius of curvature of said anterior surface is less than the radius of curvature of said posterior surface.

4. The insert of claim 1 wherein the thickness of said insert is less than about 1mm.

5. The insert of claim 1 wherein he diameter of said insert is between about 3 to about 6mm.

6. The insert of claim 1 wherein said insert is formed from materials selected from non-bioerodible hydrophilic, hydrophobic, bioerodible and biodegradable materials.

7. The insert of claim 6 wherein said insert is formed from bioerodible, biodegradable or non-bioerodible hydrophilic materials.

2. An ocular insert capable of dispensing a medicinal agent directly to the eye comprising a substantially circular disc having a concave posterior surface for placement in contact with the sclera of the eye and a convex anterior surface for placement in contact with an eyelid and wherein the radius of curvature of said osterior surface is less than the radius of curvature of the sclera, the center thickness of said insert is less than about 1.5mm, and the ratio of the curvature of said posterior concave surface to the radius of curvature of the sclera is less than about 0.8mm.

8. The insert of claim 2 wherein the radius of curvature of said anterior surface is less than the radius of curvature of said posterior surface.

9. The insert of claim 8 wherein said insert comprises a polymeric material.

10. The insert of claim 9 wherein the diameter is about 3.5 to about 4.5mm.

11. The insert of claim 9 wherein the thickness of said insert is less than about 1 mm.

12. The insert of claim 9 wherein said insert is formed from non-bioerodible materials.

13. The insert of claim 12 wherein said insert is formed from materials containing hydroxyalkyl esters.

14. The insert of claim 9 wherein said insert is formed from hydrophobic materials.