Pharmaceutically useful meso-azacyclic amides of imidazopyridine carboxylic acids and analogs thereof
First Claim
1. A compound of the formula
the stereoisomers and pharmaceutically acceptable salts thereof, wherein Ar represents a radical of the formula. ##STR27## Wherein in Group A, R1 is hydrogen, or C1-6 alkyl, R2 is hydrogen, or halogen;
In Group H, R15 and R16 are hydrogen or --CH═
CH--CH═
CH--;
X is NH or O; and
Z represents a radical of the formula ##STR28## wherein q is 1 or 2.
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Abstract
The imidazopyridines containing meso-azacycle side chains as described herein find utility as antagonists of the serotonin 5-HT3 receptor. As such they are useful for the treatment of humans and animals wherein antagonism of 5-HT3 receptors is benefical. Therapy is indicated for, but not limited to, the treatment of anxiety, psychoses, depression (especially depression accompanied by anxiety), cognitive disorders, substance abuse dependence and/or withdrawal, gastrointestinal motility disturbances (including esophageal reflux, dyspepsia, irritable bowel syndrome), emesis caused by chemotherapeutic agents, and visceral pain. Additionally, the compounds of the present invention may find utility as enhancers of nasal absorption of bioactive compounds.
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2 Claims
- 1. A compound of the formula
- space="preserve" listing-type="equation">Ar--CO--X--Z
the stereoisomers and pharmaceutically acceptable salts thereof, wherein Ar represents a radical of the formula. ##STR27## Wherein in Group A, R1 is hydrogen, or C1-6 alkyl, R2 is hydrogen, or halogen; In Group H, R15 and R16 are hydrogen or --CH═
CH--CH═
CH--;X is NH or O; and Z represents a radical of the formula ##STR28## wherein q is 1 or 2. - View Dependent Claims (2)
Specification