×

N-(3-hydroxy-4-piperidinyl)benzamide derivatives

  • US 5,137,896 A
  • Filed: 08/20/1991
  • Issued: 08/11/1992
  • Est. Priority Date: 10/01/1981
  • Status: Expired due to Term
First Claim
Patent Images

1. A compound of the formula:

  • ##STR60## the pharmaceutically acceptable acid addition salts thereof, the stereochemically isomeric forms, and the pharmaceutically acceptable quaternary ammonium salts thereof, wherein;

    the substituents in the 3 and 4 positions in the piperidine ring have the cis configuration;

    R1 represents a member selected from the group consisting of hydrogen, lower alkyl, (Ar1) lower alkyl, and lower alkylcarbonyl;

    R2 represents hydrogen;

    R3, R4, and R5 each independently represent hydrogen, lower alkyl, lower alkyloxy, halo, hydroxy, amino, nitro, mono- or di(lower alkyl)amino, lower alkylcarbonylamino, lower alkylcarbonyl, lower alkylcarbonyloxy, aminosulfonyl, and lower alkylsulfonyl; and

    L represents hydrogen or lower alkyloxycarbonyl,wherein in the foregoing Ar1 represents a member selected from the group consisting of phenyl being optionally substituted with up to 3 substituents each independently selected from the group consisting of halo, hydroxy, lower alkyl, lower alkyloxy, aminosulfonyl, lower alkylcarbonyl, nitro, trifluoromethyl, amino, aminocarbonyl, phenylcarbonyl wherein said phenyl may be optionally substituted with up to 3 halo atoms, and thienyl substituted with halo or lower alkyl.

View all claims
  • 0 Assignments
Timeline View
Assignment View
    ×
    ×