Heart rejection monitoring apparatus and method
First Claim
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1. A cardiac allograft rejection monitor adapted to be implanted in a patient, comprising:
- means for generating cardiac stimulation pulses,means for sensing a stimulated cardiac depolarization signal in response to the generation of a cardiac stimulation pulse,means for periodically ascertaining the value of a measured allograft rejection control parameter which is based on an analysis of the sensed stimulated cardiac depolarization signal,means for detecting changes in the measured allograft rejection control parameter over time which are indicative of the occurrence of allograft rejection, andmeans for storing information indicative of the occurrence of allograft rejection and for communicating said information to an external device.
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Abstract
An implantable cardiac allograft rejection monitoring apparatus and method for measuring stimulated intracardiac electrogram potentials, performing processing and time based analysis of changes in the potential, and deriving from the time history of the analyzed signals allograft rejection control parameters. The apparatus communicates the allograft rejection control parameters to an external communicating device and may use the parameters to control the output of an implanted drug infusion pump.
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Citations
24 Claims
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1. A cardiac allograft rejection monitor adapted to be implanted in a patient, comprising:
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means for generating cardiac stimulation pulses, means for sensing a stimulated cardiac depolarization signal in response to the generation of a cardiac stimulation pulse, means for periodically ascertaining the value of a measured allograft rejection control parameter which is based on an analysis of the sensed stimulated cardiac depolarization signal, means for detecting changes in the measured allograft rejection control parameter over time which are indicative of the occurrence of allograft rejection, and means for storing information indicative of the occurrence of allograft rejection and for communicating said information to an external device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 23)
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20. A method of monitoring cardiac allograft rejection from leads implanted in a patient'"'"'s heart, comprising the steps of:
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generating cardiac stimulation pulses, sensing a stimulated cardiac depolarization signal in response to the generated cardiac stimulation pulse, periodically ascertaining the value of a measured allograft rejection control parameter which is based on an analysis of the sensed stimulated cardiac depolarization signal, detecting changes in the measured allograft rejection control parameter over time which are indicative of the occurrence of allograft rejection, and storing information indicative of the occurrence of allograft rejection and communicating the information to an external device. - View Dependent Claims (21, 22, 24)
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Specification