Blood separation filter assembly and method
First Claim
Patent Images
1. A filter assembly having filter material of a predetermined thickness under positive pressure for the fast separation of serum or plasma from whole blood, comprising at least one layer of glass fibers having an average diameter ranging from 0.2 μ
- m to 7.0 μ
m and means to compress said filter material whereby said filter material is compressed at least 25% in thickness and to a compressed density higher than 0.5 gm/cm3.
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Abstract
Blood separation filter assemblies and methods are provided to quickly and completely separate plasma or serum from whole blood without the need of centrifugation. The filter assemblies and methods have filter materials of a predetermined thickness which are maintained under positive pressure during use. The filter materials have at least one layer of glass fibers having an average fiber diameter ranging from 0.2 μm to 7.0 μm and which are compressed at least 25% in thickness.
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Citations
25 Claims
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1. A filter assembly having filter material of a predetermined thickness under positive pressure for the fast separation of serum or plasma from whole blood, comprising at least one layer of glass fibers having an average diameter ranging from 0.2 μ
- m to 7.0 μ
m and means to compress said filter material whereby said filter material is compressed at least 25% in thickness and to a compressed density higher than 0.5 gm/cm3. - View Dependent Claims (2, 3, 4, 5, 6)
- m to 7.0 μ
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7. A clinical diagnostic device containing filtration material under positive pressure wherein said filtration material is capable of separating serum or plasma from a specified volume of whole blood in less than 15 seconds, said filtration material comprising:
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a) glass fibers having an average diameter ranging from 0.2 μ
m to 7.0 μ
m;b) being in a compressed state of at least 25% of its uncompressed state; and c) a compressed thickness of at least 0.04". - View Dependent Claims (8, 9, 10, 11)
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12. In a clinical diagnostic device having a body, a pocket for containing filtration materials to separate an analyte, closure means to close said pocket, and inlet means to receive a fluid sample into said pocket, said filtration materials comprising:
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a) at least one layer of glass fibers and having a total thickness of at least 0.04"; b) said glass fibers having an average diameters of 0.2 μ
m to 7.0 μ
m;c) said closure means being constructed and arranged to compress said glass fibers at least 25% by the application of positive pressure and to result in the glass fibers having packing density of at least 0.5 gm/cm3 ; and d) a reactive layer in contact with said filtration material for determination of an analyte. - View Dependent Claims (13, 14, 15)
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16. A process for the fast separation of serum or plasma from whole blood, comprising:
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a) providing a filtration assembly having a well of a predetermined depth, a cover for said well and means to introduce whole blood into said well; b) placing at least one glass fiber filter layer into said well, said glass fibers of said filter layer having an average diameter ranging from 0.2 μ
m to 7.0 μ
m;c) placing said cover into said well and compressing said glass fiber filters at least 25%; d) securing said cover in said well to maintain said glass fibers in said compressed state; and e) introducing whole blood into said well for the fast separation of serum or plasma. - View Dependent Claims (17, 18, 19)
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20. A process for the fast and complete separation of serum or plasma from a whole blood sample, comprising:
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a) providing a separation filter assembly having sample inlet means, a well structure and a cover member; b) introducing a filter material comprised of glass fibers into said well structure; c) compressing said glass fibers at least 25% of their uncompressed thickness in said well structure by means of introducing and securing said cover into said well structure to thereby compress said glass fibers to a thickness of not less than 0.04" and to a density of at least 0.5 gm/cm3 ; and d) introducing a whole blood sample into said inlet means for separation. - View Dependent Claims (21, 22, 23, 24, 25)
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Specification