Capillary flow device
First Claim
1. A method for determining an analyte in a blood sample, which comprises:
- employing a device comprising a capillary passageway which provides the motive force for moving blood into the device, wherein said passageway contains a reagent that interacts with said blood to cause a change in the fluidity of said blood, thereby providing a detectible signal;
introducing blood into said capillary passageway;
allowing said blood to transit at least a portion of said passageway and react with said reagent; and
detecting a change in the fluidity of said blood as a measure of the presence of an analyte in or property of said blood sample.
4 Assignments
0 Petitions
Accused Products
Abstract
Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastics devices is also described along with various control devices for use with the basic device.
314 Citations
4 Claims
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1. A method for determining an analyte in a blood sample, which comprises:
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employing a device comprising a capillary passageway which provides the motive force for moving blood into the device, wherein said passageway contains a reagent that interacts with said blood to cause a change in the fluidity of said blood, thereby providing a detectible signal; introducing blood into said capillary passageway; allowing said blood to transit at least a portion of said passageway and react with said reagent; and detecting a change in the fluidity of said blood as a measure of the presence of an analyte in or property of said blood sample. - View Dependent Claims (2, 3, 4)
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Specification