Apparatus for separation of blood components

• US 5,141,645 A
• Filed: 06/05/1991
• Issued: 08/25/1992
• Est. Priority Date: 01/24/1986
• Status: Expired due to Term

• Current Assignee: Terumo Corporation
• Original Assignee: Terumo Corporation
• Inventors: Yamamoto, Kiyoko, Shiraki, Hiroshi, Kawaoka, Tatsuhiko, Oonaka, Yukihiro, Kitagawa, Akiko
• Primary Examiner(s): Dawson, Robert A.
• Assistant Examiner(s): KIM, SUN U
• Application Number:
  US07/710,390
• Time in Patent Office: 447 Days
• Field of Search: 210/513, 210/514, 210/515, 210/206, 210/252, 422/102, 604/408, 604/410
• US Class Current: 210/513
• CPC Class Codes: A61M 1/0209 Multiple bag systems for separating or storing blood components
• CPC Class Codes: Y10S 530/83 Plasma; serum

Abstract

A method for the separation of blood into the components and apparatus thereof, characterized by subjecting the blood to strong centrifugation thereby separating said blood into an upper layer (A) of platelet-deficient blood plasma, an intermediate layer (B) of a mixture of platelets and white blood corpuscles, and a lower layer (C) of a red blood corpuscle concentrate, adjusting the hematocrit value of said red blood corpuscle concentrate of (C) to not more than 80% by diluting said red blood corpuscle concentrate with part of said platelet-deficient blood plasma of (A), and subjecting said mixture of (B) to weak centrifugation thereby separating said mixture into a lower layer of white blood corpuscles and an upper layer of a platelet concentrate, and if desired, subjecting the remaining platelet-deficient blood plasma to the treatments of freezing, thawing, and centrifugation thereby separating said platelet-deficient blood plasma into cryoprecipitate and cryoprecipitate-deficient blood plasma, and anaratus therefor.

Claims

1. An apparatus for the separation of blood into the components thereof, comprising a blood collecting container connected via a blood introducing tubular member to a blood collecting needle, a platelet-deficient blood plasma container connected via a first blood component flow means to said blood collecting container, a white blood corpuscle container connected via a second blood component flow means to said blood collecting container and further connected via a third blood component flow means to said platelet-deficient blood plasma container, a platelet concentrate container connected via a fourth blood component flow means to said white blood corpuscle container, and a cryoprecipitatedeficient blood plasma container connected via a fifth blood component flow means to said platelet-deficient blood plasma container.

2. An apparatus according to claim 1, wherein said fourth blood component flow means is provided with conduit closure means capable of establishing communication.

3. An apparatus according to claim 1, wherein said cryoprecipitate-deficient blood plasma container includes a red blood corpuscle preserving liquid therein.