Non-stringy adhesive hydrophilic gels

• US 5,143,071 A
• Filed: 03/26/1990
• Issued: 09/01/1992
• Est. Priority Date: 03/30/1989
• Status: Expired due to Term

• Current Assignee: Ludlow Corporation (Mallinckrodt plc)
• Original Assignee: Nepera, Inc.
• Inventors: Lennon, Linda, Keusch, Preston, Czap, Christine A., Murdock, Keith A.
• Primary Examiner(s): Cohen, Lee S.
• Application Number:
  US07/499,855
• Time in Patent Office: 890 Days
• Field of Search: 128/639-641, 128/798, 128/802, 128/803, 604/20, 604/290, 604/307, 252/500, 606/32
• US Class Current: 600/397
• CPC Class Codes: A61B 2018/00107 Coatings on the energy applicator
• CPC Class Codes: A61B 5/259 using conductive adhesive means, e.g. gels
• CPC Class Codes: A61L 15/58 Adhesives
• CPC Class Codes: A61L 24/001 Use of materials characterised by their function or physical properties
• CPC Class Codes: A61L 24/0031 Hydrogels or hydrocolloids
• CPC Class Codes: C08J 2300/10 Polymers characterised by the presence of specified groups, e.g. terminal or pendant functional groups
• CPC Class Codes: C08J 3/28 Treatment by wave energy or particle radiation
• CPC Class Codes: C08L 2666/02 Organic macromolecular compounds, natural resins, waxes or and bituminous materials
• CPC Class Codes: C08L 39/06 Homopolymers or copolymers of N-vinyl-pyrrolidones
• CPC Class Codes: C08L 71/02 Polyalkylene oxides
• CPC Class Codes: C09J 139/06 Homopolymers or copolymers of N-vinyl-pyrrolidones
• CPC Class Codes: C09J 171/02 Polyalkylene oxides
• CPC Class Codes: H01M 6/22 Immobilising of electrolyte

Abstract

The non-stringy hydrogels of this invention are comprised of a homogeneous uniform mixture of water and at least one water-soluble high molecular weight polymer. Suitable mixtures may be derived from poly(ethylene oxide) and water or poly(vinyl pyrrolidone), a viscosity-enhancing hydrophilic polymer and water, and further, may optionally contain an effective amount of a water-soluble electrolyte to provide conductive non-stringy materials. These polymeric mixtures which are crosslinked by exposure to radiant energy provide gel-like solids which are sufficiently tacky and adhesive to adhere to the subjects'"'"' skin and yet are substantially non-stringy and non-aggressive such that contact with such hydrogels imparts less discomfort to the user. In addition, the consumer utilizing the products of this invention would not experience the objectionable sticky, stringy sensation associated with existing conductive adhesive gels.

Claims

1. A non-stringy adhesive hydrophilic gel comprising a homogeneous mixture of water and at least one water-soluble polymer present at a concentration of at least about 7 percent by weight of said mixture, said water-soluble polymer having a weight average molecular weight of at least about 200 kD, which mixture had been exposed to a dose of radiant energy effective to provide a non-stringy hydrophilic gel which exhibits a sharp, substantially featureless force-displacement profile, has an Adhesion Energy Density (AED) of at least about 5 to less than about 50 g/cm and has a peak-force value of at least about 180 grams.

2. The gel of claim 1 in which said water-soluble polymer is poly(ethylene oxide) (PEO).

3. The gel of claim 1 in which said water-soluble polymer comprises poly(vinyl pyrrolidone) and a viscosity-enhancing hydrophilic polymer having a weight average molecular weight in excess of about 100 kD.

4. The gel of claim 1, 2 or 3 in which said mixture further comprises an amount of a water-soluble electrolyte effective to reduce the transverse electrical resistance of said gel to an impedance at 60 Hz of less than about 1,000 ohms.

5. The gel of claim 1, 2 or 3 in which said water-soluble polymer is present at a concentration of at least about 7 to less than about 35 percent by weight of said mixture.

6. The gel of claim 1, 2 or 3 in which said water-soluble polymer is present at a concentration of at least about 10 to about 25 percent by weight of said mixture.

7. The gel of claim 1, 2 or 3 in which said mixture further comprises an additive uniformly dispersed therein.

8. The gel of claim 7 in which said additive is selected from the group consisting of preservatives, stabilizers, fire retardants, pigments, refractive particles, bacteriacides, fungicides, antibiotics, cosmetics, moisturizers, pharmaceuticals, therapeutic agents, and mixtures thereof.

9. The gel of claim 7 in which said additive comprises a biocide.

10. The gel of claim 7 in which said additive is present at a concentration of about 0.001 percent to about 6 percent by weight of said mixture.

11. The gel of claim 1 which further comprises a low area-weight scrim in intimate contact therewith.

12. The gel of claim 11 in which said scrim is manufactured from a synthetic water-insoluble polymer.

13. The gel of claim 4 in which said electrolyte is an inorganic salt.

14. The gel of claim 4 in which said electrolyte is selected from the group consisting of alkali metal salts, alkaline earth metal salts, and mixtures thereof.

15. The gel of claim 4 in which said electrolyte is selected from the group consisting of potassium chloride, sodium chloride, magnesium sufate, magnesium acetate, and mixtures thereof.

16. The gel of claim 4 in which said electrolyte is present at a concentration of about 0.1 weight percent to about 10 weight percent of said mixture.

17. The gel of claim 1 in which said mixture had been exposed to a dose of radiant energy equivalent to greater than about 0.5 Mrad to less than about 4.5 Mrad.

18. The gel of claim 1 in which said mixture had been exposed to a dose of radiant energy equivalent to about 0.75 Mrad to about 2.5 Mrad.

19. The gel of claim 3 in which said viscosity-enhancing hydrophilic polymer is selected from the group consisting of polyacrylamide, poly(vinyl alcohol), polacrylate, poly(ethylene oxide), poly(ethylene imine), carboxymethylcellulose, methylcellulose, polyacrylamide sulfonic acid, polyacrylonitrile, agar, dextran, dextrin, carageenan, xanthan, guar, derivatives, mixtures, blends, and copolymers thereof.

20. The gel of claim 3 in which said viscosity-enhancing hydrophilic polymer comprises poly(ethylene oxide).

21. The gel of claim 3 in which said viscosity-enhancing hydrophilic polymer comprises a cellulose derivative.

22. The gel of claim 3 in which said viscosity-enhancing hydrophilic polymer is present at a concentration of about 0.5 to about 5 percent by weight of said mixture.

23. The gel of claim 1, 2 or 3 in which said mixture has a viscosity of at least about 8,000 cps.

24. The gel of claim 1, 2 or 3 in which said mixture further comprises an amount of a water-soluble electrolyte effective to reduce the transverse electrical resistance of said mixture to an impedance at frequencies between about 10 Hz to about 5 MHz of less than about 100 ohms.

25. The gel of claim 1 in which said water-soluble polymer has a weight average molecular weight of at least about 5,000 kD.

28. The gel of claim 1, 26 or 27 in which said AED value is at least about 7 to less than about 40 g/cm.

29. The gel of claim 28 in which said peak-force has a value of at least about 250 grams.

30. The gel of claim 28 in which said peak-force has a value of at least about 400 grams.

32. The gel of claim 2 or 26 in which said PEO is present at a concentration of at least about 7 to about 15 percent by weight of said mixture.

26. A non-stringy adhesive hydrophilic gel comprising a homogeneous mixture of water and poly(ethylene oxide) (PEO) present at a concentration of at least about 7 percent by weight to less than about 35 percent by weight of said mixture, said PEO having a weight average molecular weight of about 500 kD to about 5,000 kD,

which mixture had been exposed to a dose of radiant energy, relative to the amount of said PEO present, within the area of the radiation dose versus PEO concentration curve whose upper and lower boundaries are defined substantially by the relationships NS(C) and A(C), respectively,

View Dependent Claims (31)

31. The gel of claim 26 in which said poly(ethylene oxide) is present at a concentration of at least about 10 to about 25 percent by weight of said mixture.

27. A non-stringy adhesive hydrophilic gel comprising a homogenous mixture of water, poly(vinyl pyrrolidone) (PVP) and a viscosity-enhancing hydrophilic polymer having a weight average molecular weight in excess of about 100 kD, said PVP having a weight average molecular weight of about 500 kD to about 2,000 kD and present at a concentration of at least about 6 percent to less than about 35 percent by weight of said mixture,

which mixture had been exposed to a dose of radiant energy, relative to the amount of said PVP present, within the area of the radiation dose versus PVP concentration curve whose upper and lower boundaries are defined substantially by the relationships NS(C) and A(C), respectively,

View Dependent Claims (33)

33. The gel of claim 27 in which said poly(vinyl pyrrolidone) is present at a concentration of at least about 10 to about 25 percent by weight of said mixture.

34. A dressing comprising a non-stringy adhesive hydrophilic gel, which gel comprises a homogeneous mixture of (i) water, (ii) at least one water-soluble polymer present at a concentration of at least about 7 percent by weight of said mixture and having a weight average molecular weight of at least about 200 kD, and (iii) at least one additive present at a concentration of about 0.001 percent to about 6 percent by weight of said mixture,

which mixture had been exposed to a dose of radiant energy effective to provide a non-stringy hydrophilic gel which exhibits a sharp substantially featureless force-displacement profile, has an AED value of at least about 5 to less than about 50 gm/cm and has a peak-force value of at least about 180 grams.

35. The dressing of claim 34 in which said water-soluble polymer is poly(ethylene oxides) (PEO).

36. The dressing of claim 35 in which said PEO is present at a concentration of at least about 7 to about 15 percent by weight of said mixture.

37. The dressing of claim 34 in which said water-soluble polymer comprises poly(vinyl pyrrolidone) and a viscosity-enhancing hydrophilic polymer having a weight average molecular weight in excess of about 100 kD.

38. The dressing of claim 34 in which said additive comprises a physiologically active agent.

39. The dressing of claim 34 in which said additive comprises a therapeutic drug.

40. The dressing of claim 34 in which said additive comprises a cosmetic formulation.

41. The dressing of claim 34 in which said additive comprises at least one preservative.

42. The dressing of claim 34 in which said water-soluble polymer has a weight average molecular weight of at least about 5,000 kD.

43. The dressing of claim 34 in which said AED value is at least about 7 to less than about 40 g/cm.

44. The dressing of claim 34 in which said water-soluble polymer is present at a concentration of at least about 10 to about 25 percent by weight of said mixture.

45. An electrode comprising (a) a conductive non-stringy adhesive hydrophilic gel, which gel comprises a homogeneous mixture of (i) water, (ii) at least one water-soluble polymer present at a concentration of at least about 7 percent by weight of said mixture and having a weight average molecular weight of at least about 200 kD, and (iii) an amount of a water-soluble electrolyte effective to reduce the transverse electrical resistance of said gel to an impedance at 60 Hz of less than about 1,000 ohms,

which mixture had been exposed to a dose of radiant energy effective to provide a non-stringy hydrophilic gel which exhibits a sharp substantially featureless force-displacement profile, has an AED value of at least about 5 to less than about 50 gm/cm and has a peak-force value of at least about 180 grams;

and (b) a suitable conductive member, in intimate contact with said gel, to which may be connected external electrical apparatus.

46. The electrode of claim 45 in which said water-soluble polymer is poly(ethylene oxide) (PEO).

47. The electrode of claim 46 in which said PEO is present at a concentration of at least about 7 to about 15 percent by weight of said mixture.

48. The electrode of claim 45 in which said water-soluble polymer comprises poly(vinyl pyrrolidone) and a viscosity-enhancing hydrophilic polymer having a weight average molecular weight in excess of about 100 kD.

49. The electrode of claim 45 in which said water-soluble polymer has a weight average molecular weight of at least about 5,000 kD.

50. The electrode of claim 45 in which said AED value is at least about 7 to less than about 40 g/cm.

51. The electrode of claim 45 in which said water-soluble polymer is present at a concentration of at least about 10 to about 25 percent by weight of said mixture.