Injection device for use with a deformable ampoule

• US 5,147,311 A
• Filed: 05/03/1990
• Issued: 09/15/1992
• Est. Priority Date: 09/09/1987
• Status: Expired due to Fees

• Current Assignee: Pharma Consult Ges.M.B.H.
• Original Assignee: Ewald Pickhard
• Inventors: Pickhard, Ewald
• Primary Examiner(s): Hirsch, Paul J.
• Application Number:
  US07/477,831
• Time in Patent Office: 866 Days
• Field of Search: 604/155, 604/151, 604/131, 604/143, 604/133, 604/135, 604/134, 604/153, 604/148, 128/DIG. 12
• US Class Current: 604/153
• CPC Class Codes: A61M 2005/14506 mechanically driven, e.g. spring or clockwork
• CPC Class Codes: A61M 2005/1581 Right-angle needle-type devices
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/148 flexible, e.g. independent bagsA61M5/155 takes precedence
• CPC Class Codes: A61M 5/2425 by compression of deformable ampoule or carpule wall

Abstract

An injection device (1) has a housing (2) in which is arranged a holder for a deformable, medicament-containing ampoule (4). To a frontal end region is linked an injection needle (5) which communicates with the interior of the ampoule and with a driving device linked to the other frontal end region of the ampoule, opposite the frontal end region facing the injection needle. The ampoule (4) is arranged and held within a support device (13) that extends between both frontal end regions.

Claims

1. An injection device for selectively dispensing a small, controlled amount of a medicament into a body of a patient, comprising

(a) a deformable bag-shaped ampoule having a closed end and an opposite open dispensing end, the ampoule having a longitudinal axis and defining an interior chamber containing the medicament,

(b) a coaxial support receiving the ampoule between the ends thereof,

(c) a housing providing an abutment for the ampoule support,

(d) a hypodermic needle,

(e) a device for sealing the open ampoule end and for holding the hypodermic needle, the device comprising

(1) a holding element fixedly held in the support,

(1) a carrier for the hypodermic needle, the carrier being mounted on the holding element for axial adjustment relative thereto, and

(2) a piercing device penetrating through the holding element into the interior ampoule chamber upon axial adjustment of the hypodermic needle carrier, the piercing device having an axial bore receiving medicament from the interior ampoule chamber upon penetration thereof by the piercing device,

(f) an actuating mechanism for compressing the deformable ampoule and extending into the housing, the actuating mechanism comprising

(1) a piston slidable in an axial direction towards the sealing and holding device, the piston acting upon the closed ampoule end for compressing the deformable ampoule,

(2) the support having a guide track extending between the ampoule ends and being arranged for guiding the slidable piston, and

(g) a constricted, pressure-regulating channel extending through the hypodermic needle carrier, the channel connecting the interior ampoule chamber to the hypodermic needle through the bore of the piercing device.

2. The injection device of claim 1, wherein the sealing and holding device comprises a spacing element between the holding element and the hypodermic needle carrier, the constricted, pressure-regulating channel extending through the spacing element.

3. The injection device of claim 2, wherein the holding element is affixed to the open ampoule end.

4. The injection device of claim 3, wherein the holding element is comprised of a rigid synthetic resin body and is bonded to the open ampoule end.

5. The injection device of claim 2, wherein the hypodermic needle carrier and spacing element define adjoining faces extending perpendicularly to a longitudinal axis of the ampoule, the constricted pressure-regulating channel being defined by a recess in one of the adjoining faces and facing the other face, the recess being closed by the other face.

6. The injection device of claim 5, wherein the constricted, pressure-regulating channel comprises a plurality of annular channel portions extending concentrically about the longitudinal ampoule axis, the channel portions having different diameters, each channel portion extending over an arc of about 270°

and radially alternating ones of the concentric channel portions being connected to each other.

7. The injection device of claim 5, wherein the constricted, pressure-regulating channel extends spirally about the longitudinal ampoule axis.

8. The injection device of claim 1, wherein the holding element is comprised of two parts, further comprising a barrier membrane interposed between the two holding element parts.

9. The injection device of claim 1, further comprising a device for coupling the hypodermic needle carrier to the holding element.

10. The injection device of claim 9, wherein the holding element comprises a threaded socket and the hypodermic needle carrier has a threaded coupling member threadedly attachable to the socket to form the coupling device.

11. The injection device of claim 10, wherein the threaded socket and the threaded coupling member extend parallel to a longitudinal axis of the ampoule extending between the ampoule ends.

12. The injection device of claim 1, further comprising a microfilter arranged between the piercing member and the hypodermic needle, the microfilter having a face facing towards the hypodermic needle and covering the constricted, pressure-regulating channel.

13. The injection device of claim 12, wherein the microfilter comprises a holding ring, a clamping disc and a filter membrane arranged between the holding ring and the clamping disc, the holding ring comprising an annular flange having an inner diameter corresponding an outer diameter of the clamping disc.

14. The injection device of claim 13, wherein the holding ring and the clamping disc have peripheral faces engaged in a friction fit.

15. The injection device of claim 1, wherein the support and the ampoule are tubular, the support having an elongated interior chamber receiving the ampoule.

16. The injection device of claim 1, wherein the guide track extends in the support parallel to the longitudinal axis of the ampoule and the piston has guide elements slidable along the guide track.

17. The injection device of claim 16, wherein the guide track comprises two diametrically opposed elongated grooves in the support.

18. The injection device of claim 1, wherein the actuating mechanism comprises spring drives at respective sides of the support, further comprising a device for arresting the slidable piston in an end position spaced from the support.

19. The injection device of claim 18, wherein the actuating mechanism comprises a transverse strut engaged by the spring drives and the arresting device comprises a catch for holding the transverse strut in position.

20. The injection device of claim 19, wherein the catch is pivotal about an axis extending parallel to the transverse strut.

21. The injection device of claim 20, further comprising a pivotal element carrying the catch, a two-part casing for the injection device, one casing part being a hinged cover, and a pressure button on the cover and aligned with the pivotal element upon closing the cover for pressing upon the pivotal element.

22. The injection device of claim 21, wherein the casing defines an opening wherethrough the hypodermic needle projects.

23. The injection device of claim 1, further comprising a control for the actuating mechanism, the control comprising a sensor for monitoring vital data of the patient.

24. The injection device of claim 23, wherein the control further comprises a motion sensor and a control member responsive to motions monitored by the motion sensor whereby the actuating mechanism compresses the ampoule in response to the monitored motions to deliver a desired amount of the medicament from the ampoule to the hypodermic needle.

25. The injection device of claim 1, further comprising a pressure throttling frusto-conical body having a periphery wherein two circumferential recesses are formed to define portions of the constricted, pressure-regulating channel, the frusto-conical body having a center axis and the recesses extending perpendicularly to the center axis and being spaced from each other therealong, each circumferential recess having a starting and a terminal end spaced from each other by an angle between 10°

and 45°

in the circumferential direction, and a connecting channel between the starting end of one recess and the terminal end of the other recess.

26. The injection device of claim 25, wherein the connecting channel is a recess in the periphery of the frusto-conical body, the recess extending in the direction of a rectilinear generatrix of the periphery.

27. The injection device of claim 1, further comprising a pressure throttling frusto-conical body having a periphery wherein a spiral recess defines the constricted, pressure-regulating channel.

28. The injection device of claim 1, wherein the holding element comprises a receiving body having a substantially cylindrical periphery and defining a frusto-conical recess, further comprising a pressure-throttling frusto-conical body fitted in the frusto-conical recess and having a periphery defining the constricted, pressure-regulating channel.

29. The injection device of claim 28, further comprising diametrically opposed abutments arranged on the periphery of the receiving body, a pointed elongated cylindrical element projecting from the receiving body away from the frusto-conical recess and towards the sealing member, the cylindrical element defining a central elongated bore, and a cylindrical closure nipple mounted on the receiving body over the frusto-conical recess and body, the nipple being bonded to the receiving body.