Multi-valve catheter for improved reliability

• US 5,147,332 A
• Filed: 05/17/1991
• Issued: 09/15/1992
• Est. Priority Date: 05/17/1991
• Status: Expired due to Term

• Current Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Original Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Inventors: Moorehead, H. Robert
• Primary Examiner(s): YASKO JR, JOHN D
• Application Number:
  US07/702,032
• Time in Patent Office: 487 Days
• Field of Search: 604/264, 604/247, 604/280, 604/281, 604/282, 604/283, 604/284, 604/164, 604/168, 604/43, 604/44, 604/45
• US Class Current: 604/247
• CPC Class Codes: A61M 25/0075 Valve means

Abstract

A novel apparatus for a catheter for use in aspirating and/or infusing fluids into a patient. The catheter, having a proximal end and a distal end, comprises a plurality of valves in the walls of the catheter comprised of relatively soft material while maintaining a predetermined degree of structural integrity at the catheter tip. The plurality of valves are radially distributed in offset relation around the distal end of the catheter such that no two valves lie in any one radial plane. Similarly, the plurality of valves are longitudinally separated or offset in their placement at relatively short, but differentiated, distances from the distal end of the catheter such that no two valves lie in any one axial plane. The radial and longitudinal separation of the valves helps avoid structrual weakness in the catheter, particularly at the distal end of the catheter. The catheter may be a single-lumen catheter, or a multi-lumen catheter.

The plurality of valves are comprised of a primary valve constructed to be preferably operable during infusion and/or aspiration, and at least one secondary valve which operates as a surrogate should the primary valve become partially or totally occluded. The catheter enables repeated infusion and/or aspiration over a period of time.

The present invention also includes methods for using and manufacturing the catheter by following certain steps.

Claims

1. A catheter for use in aspirating or infusing fluids to a patient, the catheter comprising:

a cannula having an outer-wall made of a biocompatible material, the cannula having a distal end and a proximal end and at least one internal lumen for transmitting liquids, the at least one internal lumen providing for two-way fluid flow between the proximal end and the distal end of the cannula such that the fluid flow is initiated by the application of a pressure differential to the fluid;

means for selectively communicating between the at least one lumen of the cannula and the exterior of the cannula, said means for selectively communicating comprising a plurality of valves, the plurality of valves being comprised of a primary valve and a secondary valve, the primary valve being constructed to operate at a lower threshold pressure differential than the secondary valve so as to be preferably operable relative to the secondary valve during aspiration or infusion, the secondary valve acting as a surrogate to the primary valve should the primary valve fail to operate.

2. A catheter for use in aspirating or infusing fluids to a patient as in claim 1, wherein the cannula is a single lumen catheter.

3. A catheter for use in aspirating or infusing fluids to a patient as in claim 1, wherein the cannula is a multi-lumen catheter.

4. A catheter for use in aspirating or infusing fluids to a patient as in claim 1, wherein at least one internal lumen has a cross-section that is transversely asymmetrical and comprises at least one corner, the corner forming part of a localized reduced thickness region in the cannular wall.

5. A catheter for use in aspirating or infusing fluids to a patent as in claim 3, wherein the plurality of valves in the multi-lumen catheter are capable of being mechanically weakened.

6. A catheter for use in aspirating or infusing fluids to a patient as in claim 3, wherein the plurality of valves in the multi-lumen catheter are capable of being mechanically weakened to different degrees by varying the lengths of the valves.

7. A catheter for use in aspirating or infusing fluids to a patient as in claim 3, wherein the plurality of valves in the multi-lumen catheter are capable of being mechanically weakened to different degrees by varying the wall thickness between that at least one lumen and the exterior of the cannula in the valve area.

8. A catheter for use in aspirating or infusing fluids to a patient as in claim 3, wherein the plurality of valves in the single lumen cannula are capable of being chemically softened.

9. A catheter as recited in claim 1, wherein each of the plurality of valves comprises a two-way valve.

10. A catheter as recited in claim 1, wherein each of the plurality of valves comprises a slit extending through the wall of the catheter, said slit having edges which abut each other to prevent fluid flow therethrough, the edges moving outwardly from one another upon the application of a positive pressure differential to the at least one lumen to infuse fluids from the at least one lumen, and the edges moving inwardly upon the application of a negative pressure differential to the at least one lumen to withdraw fluid from the at least one lumen.

11. A catheter as recited in claim 1, wherein said primary valve is located distal of said secondary valve along the length of said cannula.

13. A catheter for use in aspirating or infusing fluids to a patient as in claim 2, wherein the plurality of valves in the single lumen cannula are capable of being mechanically weakened.

14. A catheter for use in aspirating or infusing fluids to a patient as in claim 1, wherein the plurality of valves are three-position valves.

15. A catheter for use in aspirating or infusing fluids to a patient as in claim 2, wherein the valves have a Shore A durometer in the range from about 10 to about 45.

16. A catheter for use in aspirating or infusing fluids to a patient as in claim 2, wherein the valves have a Shore A durometer in the range from about 20 to about 35.

17. A catheter for use in aspirating or infusing fluids to a patient as in claim 2, wherein the valves have a Shore A durometer in the range from about 24 to about 31.

18. A catheter for use in aspirating or infusing fluids to a patient as in claim 1, wherein the valves are capable of operating to consistently and reproducibly open and close over long-term indwelling conditions.

19. A catheter for use in aspirating or infusing fluids to a patient as in claim 18, wherein the valves are capable of operating to consistently and reproducibly open and close at low-pressure differentials.

20. A catheter for use in aspirating or infusing fluids into a patient as in claim 19, wherein the valves are capable of operating to consistently and reproducibly open and close at push pressures in the range from about 1.5 psig to about 10.0 psig and at pull pressures in the range from about 0.3 psig to about 2.0 psig.

21. A catheter for use in aspirating or infusing fluids to a patient as in claim 3, wherein the primary valve is preferably operable to any secondary valves because the primary valve is mechanically weakened to a greater degree than any secondary valves.

22. A catheter for use in aspirating or infusing fluids to a patient as in claim 1, wherein the primary valve has a slit length in the range from about 0.300 to about 0.400 inches and the secondary valves have a slit length in the range from about 0.150 to about 0.250 inches.

23. A catheter for use in aspirating or infusing fluids to a patient as in claim 1, wherein the primary valve has a slit length in the range from about 0.330 to about 0.370 inches and the secondary valves have a slit length in the range from about 0.180 to about 0.220 inches.

24. A catheter for use in aspirating or infusing fluids to a patient as in claim 1, wherein the primary valve has a slit length in the range from about 0.340 to about 0.360 inches and the secondary valves have a slit length in the range from about 0.190 to about 0.210 inches.

26. A catheter for use in aspirating or infusing fluids to a patient in claim 1, wherein the cannula is a long-term indwelling intravascular catheter.

27. A catheter for use in aspirating or infusing fluids to a patient as in claim 1, wherein the valves are longitudinally displaced from each other while still providing structural integrity at the distal end of the cannula for defining at least one lumen.

28. A catheter for use in aspirating or infusing fluids to a patient as in claim 1, wherein the valves are longitudinally displaced from each other so that the distal end of the proximal valve is substantially the same longitudinal distance from the distal end of cannula as the proximal end of the distal valve.

29. A catheter for use in aspirating or infusing fluids to a patient as in claim 1, wherein the valves are radially displaced from each other while still providing structural integrity at the distal end of the cannula for defining at least one lumen.

30. A catheter for use in aspirating or infusing fluids to a patient as in claim 29, wherein the valves are radially displaced from the each other in the range from about 10 to about 180 degrees.

31. A catheter for use in aspirating or infusing fluids to a patient as in claim 1, wherein the cannula has a Shore A durometer in the range from about 45 to about 70.

32. A catheter for use in aspirating or infusing fluids to a patient as in claim 1, further comprising a length of resilient tubing mounted to said cannula and extending along a relatively short distal end segment thereof, the valves being located along the short distal end segment of the catheter to which the tubing is mounted.

33. A catheter for use in aspirating or infusing fluids to a patient in claim 32, further comprising means defining an aperture in the tubing wall directly opposite and surrounding each valve, each said aperture being wider than its corresponding valve so that tubing wall portions on opposite sides of the slit overhang the opposite edges of the associated aperture.

34. A catheter for use in aspirating or infusing fluids to a patient in claim 1, wherein the cannula has a region subject to compressive forces during infusion and aspiration, the cannula having means positioned within the lumen of the cannula for site-selectively reinforcing the region of the cannula where the compressive forces are applied against the cannula.

35. A catheter for use in aspirating or infusing fluids to a patient as in claim 34, wherein the means for site-selectively reinforcing the cannula comprises an inner tubular sleeve capable of withstanding compressive forces generated by the body of a patient, said inner tubular sleeve is inserted site-selectively within the cannula.

12. A catheter for use in aspirating or infusing fluids to a patient, the catheter comprising:

a single-lumen cannula having an outer-wall made of a biocompatible material, the cannula having a distal end and a proximal end and an internal lumen for transmitting liquids, the internal lumen providing for two-way fluid flow between the proximal end and the distal end of the cannula such that the fluid flow is initiated by the application of a pressure differential to the fluid;

a plurality of multi-position valves communicating between the lumen of the cannula and the exterior of the cannula having edges which abut each other to prevent fluid flow therethrough, the edges moving outwardly from one another upon the application of a positive pressure differential to the lumen to infuse fluids from the lumen, the edges moving inwardly upon the application of a negative pressure differential to the lumen to withdraw fluid from the lumen, and wherein the material from which the cannula adjacent each valve is chemically softened with silicone oil in order to provide for the two-way operation; and

the plurality of valves comprised of a primary valve constructed to be preferably operable during aspiration or infusion, and at least one secondary valve acting as a surrogate to the primary valve should the primary valve fail to operate.

25. A catheter for use in aspirating or infusing fluids to a patient, the catheter comprising:

a single-lumen cannula having an outer-wall made of a biocompatible material, the cannula having a distal end and a proximal end and an internal lumen for transmitting liquids, the internal lumen providing for two-way fluid flow between the proximal end and the distal end of the cannula such that the fluid flow is initiated by the application of a pressure differential to the fluid;

a plurality of multi-position valves communicating between the lumen of the cannula and the exterior of the cannula having edges which abut each other to prevent fluid flow therethrough, the edges moving outwardly from one another upon the application of a positive pressure differential to the lumen to infuse fluids from the lumen, the edges moving inwardly upon the application of a negative pressure differential to the lumen to withdraw fluid from the lumen; and

the plurality of valves comprised of a primary valve constructed to be preferably operable during aspiration or infusion, and at least one secondary valve acting as a surrogate to the primary valve should the primary valve fail to operate, wherein the primary valve is preferably operable to any secondary valves because the primary valve is chemically softened to a greater degree than any secondary valves.

36. A multi-lumen catheter for use in aspirating or infusing fluids to a patient, the multi-lumen catheter comprising:

a cannula having an outer-wall made of a biocompatible material, the cannula having a distal end and a proximal end and a plurality of internal lumens for transmitting liquids, the internal lumens providing for two-way fluid flow between the proximal end and the distal end of the cannula such that the fluid flow is initiated by the application of a pressure differential to the fluid;

a plurality of three-position valves communicating between each of the lumens of the cannula and the exterior of the cannula having edges which abut each other to prevent fluid flow therethrough, the edges moving outwardly from one another upon the application of a positive pressure differential to the lumens to infuse fluids from the lumens, the edges moving inwardly upon the application of a negative pressure differential to the lumen to withdraw fluid from the lumens; and

the plurality of valves comprised of a primary valve and a secondary valve, the primary valve constructed to operate at a lower threshold pressure differential than the secondary valve so as to be preferably operable relative to the secondary valve during aspiration or infusion, and the secondary valve acting as a surrogate to the primary valve should the primary valve fail to operate.

37. A multi-lumen catheter for use in aspirating or infusing fluids to a patient as in claim 36, wherein the valves are capable of being mechanically weakened.

38. A multi-lumen catheter for use in aspirating or infusing fluids to a patient as in claim 36, wherein the valves are capable of being mechanically weakened to different degrees by varying the lengths of the valves.

39. A multi-lumen catheter for use in aspirating or infusing fluids to a patient as in claim 36, wherein the valves are capable of being mechanically weakened to different degrees by varying the wall thickness between the lumens and the exterior of the cannula in the valve area.

40. A multi-lumen catheter for use in aspirating or infusing fluids to a patient as in claim 36, wherein the valves are capable of operating to consistently and reproducibly open and close over long-term indwelling conditions.

41. A multi-lumen catheter for use in aspirating or infusing fluids to a patient as in claim 40, wherein the valves are capable of operating to consistently and reproducibly open and close at low pressure differentials.

42. A catheter for use in aspirating or infusing fluids into a patient as in claim 41, wherein the valves are capable of operating to consistently and reproducibly open and close at push pressures in the range from about 1.5 psig to about 10.0 psig and at pull pressures in the range from about 0.3 psig to about 2.0 psig.

43. A multi-lumen catheter for use in aspirating or infusing fluids to a patient as in claim 36, wherein each primary valve in each of the lumens is preferably operable to any second valves because the primary valve is mechanically weakened to a greater degree than any of the secondary valves.

44. A multi-lumen catheter for use in aspirating or infusing fluids to a patient as in claim 36, wherein the cannula is a long-term indwelling intravascular catheter.

45. A multi-lumen catheter for use in aspirating or infusing fluids to a patient as in claim 36, wherein the valves are longitudinally displaced from each other while still providing structural integrity at the distal end of the cannula for defining a plurality of lumens.

46. A multi-lumen catheter for use in aspirating or infusing fluids to a patient as in claim 36, wherein the valves are longitudinally displaced from each other so that the distal end of the proximal valve is substantially the same longitudinal distance from the distal end of cannula as the proximal end of the distal valve.

47. A multi-lumen catheter for use in aspirating or infusing fluids to a patient as in claim 36, wherein the valves are radially displaced from each other while still providing structural integrity at the distal end of the cannula for defining a plurality of lumens.

70. A catheter for use in aspirating or infusing fluids to a patient as in claim 46, wherein the valves have a Shore A durometer in the range from about 45 to about 70 prior to being softened.

48. A catheter for use in aspirating or infusing fluids to a patient, the catheter comprising:

a cannula having a distal end and a proximal end and defining a tubular wall providing for fluid flow from the proximal end to the distal end, fluid being initiated by applying a pressure differential at the proximal end of the cannula; and

a plurality of multi-positioned valves placed in the wall layers of the cannula near the distal end, each of the plurality of valves enabling fluid flow through the cannula through the valve subject to the differential applied to the proximal end, each of the plurality of valves being configured to reseal such that fluid is prevented from passing through the valve when the pressure differential is terminated, the plurality of valves comprised of a primary valve and a secondary valve, the primary valve constructed to operate at a lower threshold pressure differential than the secondary valve so as to be preferably operable relative to the secondary valve during aspiration or infusion, and the secondary valve acting as a surrogate to the primary valve should the primary valve fail to operate.

49. A catheter for use in aspirating or infusing fluids to a patient as in claim 48, wherein the cannula is a single-lumen catheter.

50. A catheter for use in aspirating or infusing fluids to a patient as in claim 48, further comprising wall means defining a plurality of independently usable lumens extending substantially the entire length of the cannula, the lumen-defining wall means being internally located at the distal end, each lumen being capable of communicating with a plurality of valves.

51. A catheter for use in aspirating or infusing fluids to a patient as in claim 50, wherein the wall means define two independent lumens extending substantially the entire length of the cannula, each lumen being capable of communicating with a plurality of valves.

52. A catheter for use in aspirating or infusing fluids to a patient as in claim 49, wherein the valves are capable of being chemically softened.

53. A catheter for use in aspirating or infusing fluids to a patient as in claim 51, wherein the valves are capable of being mechanically weakened.

54. A catheter for use in aspirating or infusing fluids to a patient as in claim 51, wherein the valves are capable of being mechanically weakened to different degrees by varying the lengths of the valves.

55. A catheter for use in aspirating or infusing fluids to a patient as in claim 51, wherein the valves are capable of being mechanically weakened to different degrees by varying the wall thickness between the lumen and the exterior of the cannula in the valve area.

56. A catheter for use in aspirating or infusing fluids to a patient as in claim 48, wherein the valves are three-position, two-way valves.

58. A catheter for use in aspirating or infusing fluids to a patient as in claim 48, wherein the primary valve comprises a region of enhanced flexibility in the material from which the primary valve is comprised.

59. A catheter for use in aspirating or infusing fluids to a patient as in claim 48, wherein the primary valve comprises a relatively thin localized site in the material from which the primary valve is comprised.

60. A catheter for use in aspirating or infusing fluids to a patient as in claim 48, wherein the valves are capable of operating to consistently and reproducibly open and close over long-term indwelling conditions.

61. A catheter for use in aspirating or infusing fluids to a patient as in claim 60, wherein the valves are capable of operating to consistently and reproducibly open and close at low pressure differentials.

62. A catheter for use in aspirating or infusing fluids into a patient as in claim 61, wherein the valves are capable of operating to consistently and reproducibly open and close at push pressures in the range from about 1.5 psig to about 10.0 psig and at pull pressures in the range from about 0.3 psig to about 2.0 psig.

63. A catheter for use in aspirating or infusing fluids to a patient as in claim 51, wherein the primary valve is preferably operable to any secondary valves because the primary valve is mechanically weakened to a greater degree than any secondary valve.

65. A catheter for use in aspirating or infusing fluids to a patient as in claim 48, wherein the cannula is a long-term indwelling intravascular catheter.

66. A catheter for use in aspirating or infusing fluids to a patient as in claim 48, wherein the valves are longitudinally displaced from each other while still providing structural integrity at the distal end of the cannula.

67. A catheter for use in aspirating or infusing fluids to a patient as in claim 48, wherein the valves are longitudinally displaced from each other so that the distal end of the proximal valve is substantially the same longitudinal distance from the distal end of the cannula as the proximal end of the distal valve.

68. A catheter for use in aspirating or infusing fluids to a patient as in claim 48, wherein the valves are radially displaced from each other while still providing structural integrity at the distal end of the cannula.

69. A catheter for use in aspirating or infusing fluids to a patient as in claim 49, wherein the valves are radially displaced from each other in the range from about 10 to about 180 degrees.

71. A catheter for use in aspirating or infusing fluids to a patient as in claim 48, further comprising a length of resilient tubing mounted to said cannula and extending along a relatively short distal end segment thereof, the valves being located along the short distal end segment of the cannula to which the tubing is mounted.

72. A catheter for use in aspirating or infusing fluids to a patient as in claim 71, further comprising means defining an aperture in the tubing wall directly opposite and surrounding each valve, each said aperture being wider than its corresponding valve so that tubing wall portions on opposite sides of the slit overhand the opposite edges of the associated aperture.

73. A catheter for use in aspirating or infusing fluids to a patient as in claim 48, wherein the cannula has a region subject to compressive forces during infusion and aspiration, the cannula having means positioned within the lumen of the cannula for site-selectively reinforcing the region of the cannula where the compressive forces are applied against the cannula.

74. A catheter for use in aspirating or infusing fluids to a patient as in claim 73, wherein the means for site-selectively reinforcing the cannula comprises an inner tubular sleeve capable of withstanding compressive forces generated by the body of a patient, said inner tubular sleeve being positioned site-selectively within the cannula.

57. A catheter for use in aspirating or infusing fluids to a patient, the catheter comprising:

a single-lumen cannula having a distal end and a proximal end and defining a tubular wall providing for fluid flow from the proximal end to the distal end, fluid being initiated by applying a pressure differential at the proximal end of the cannula; and

a plurality of multi-positioned valves placed in the wall layers of the cannula near the distal end, each of the plurality of valves enabling fluid flow through the cannula through the valve subject to the differential applied to the proximal end, each of the plurality of valves being configured to reseal such that fluid is prevented from passing through the valve when the pressure differential is terminated, the plurality of valves comprised of a primary valve constructed to be preferably operable during aspiration or infusion, and at least one secondary valve acting as a surrogate to the primary valve should the primary valve fail to operate, and wherein the cannula adjacent each valve is chemically softened with silicone in order to provide for the two-way, three-position operation.

64. A catheter for use in aspirating or infusing fluids to a patient, the catheter comprising:

a cannula having a distal end and a proximal end and defining a tubular wall providing for fluid flow from the proximal end to the distal end, fluid being initiated by applying a pressure differential at the proximal end of the cannula; and

a plurality of multi-positioned valves placed in the wall layers of the cannula near the distal end, each of the plurality of valves enabling fluid flow through the cannula through the valve subject to the differential applied to the proximal end, each of the plurality of valves being configured to reseal such that fluid is prevented from passing through the valve when the pressure differential is terminated, the plurality of valves comprised of a primary valve constructed to be preferably operable during aspiration or infusion, and at least one secondary valve acting as a surrogate to the primary valve should the primary valve fail to operate, and wherein the primary valve is preferably operable to any secondary valves because the primary valve is chemically softened to a greater degree than any secondary valve.

75. An intravascular catheter for infusing and aspirating fluids in the area surrounding the catheter, the catheter comprising:

a close-ended single lumen catheter having a distal end and a proximal end and defining a tubular wall which allows an even flow through the lumen of the catheter, the even flow being initiated when a pressure differential is applied to said catheter; and

two valves in the walls of the catheter comprised of a material for resealing when the pressure differential is withdrawn, the catheter maintaining a predetermined degree of catheter-tip rigidity to maintain structural integrity while the valves consistently and reproducibly open and close to enable infusion and aspiration, the valves comprised of a single, normally closed, linearly extending slit extending through the catheter wall, one of the two slits being radially and longitudinally displaced from the other slit while still providing structural integrity at the distal end of the catheter, the first of the two valves being a primary valve constructed to be preferably operable during aspiration or infusion, the second of the two valves acting as a surrogate to the primary valve should the primary valve fail to operate, the primary valve being treated to operate at a lower threshold pressure differential relative to the secondary valve so as to be preferably operable to the secondary valve.

76. An intravascular catheter for infusing and aspirating fluids in the area surrounding the catheter as in claim 75, wherein one of the two valves is radially displaced from the other valve in the range from about 10 to about 180 degrees.

77. An intravascular catheter for infusing and aspirating fluids in the area surrounding the catheter as in claim 75, wherein one of the two valves is longitudinally displaced from the other valve so that the distal end of the proximal valve us substantially the same longitudinal distance from the distal end of the catheter as the proximal end of the distal valve.

78. An intravascular catheter for infusing and aspirating fluids in the area surrounding the catheter as in claim 75, wherein said valves have a Shore A durometer in the range from about 10 to about 45.

79. An intravascular catheter for infusing and aspirating fluids in the area surrounding the catheter as in claim 75, wherein said valves have a Shore A durometer in the range from about 20 to about 35.

80. An intravascular catheter for infusing and aspirating fluids in the area surrounding the catheter as in claim 75, wherein said valves have a Shore A durometer in the range from about 24 to about 31.

81. An intravascular catheter for infusing and aspirating fluids in the area surround the catheter as in claim 75, wherein the valves are capable of being mechanically weakened to different degrees by varying the lengths of the valves.

82. An intravascular catheter for infusing and aspirating fluids in the area surround the catheter as in claim 75, wherein the valves are capable of being mechanically weakened to different degrees by varying the wall thickness between the lumen and the exterior of the catheter in the valve area.

83. An intravascular catheter for infusing and aspirating fluids in the area surrounding the catheter as in claim 75, wherein the valves are capable of being chemically softened.

85. An intravascular catheter for infusing and aspirating fluids in the area surrounding the catheter as in claim 75, wherein the valves are capable of operating to consistently and reproducibly open and close at low pressure differentials.

86. An intravascular catheter for infusing and aspirating fluids in the area surrounding the catheter as in claim 75, wherein the primary valve is preferably operable to any secondary valve because the primary valve is mechanically weakened to a greater degree than any secondary valve.

87. An intravascular catheter for infusing and aspirating fluids in the area surround the catheter as in claim 75, wherein the primary valve has a slit length in the range from about 0.300 to about 0.400 inches and the secondary valves have a slit length in the range from about 0.150 to about 0.250 inches.

88. An intravascular catheter for infusing and aspirating fluids in the area surround the catheter as in claim 75, wherein the primary valve has a slit length in the range from about 0.330 to about 0.370 inches and the secondary valves have a slit length in the range from about 0.180 to about 0.220 inches.

89. An intravascular catheter for infusing and aspirating fluids in the area surround the catheter as in claim 75, wherein the primary valve has a slit length in the range from about 0.360 inches and the secondary valves have a slit length in the range from about 0.190 to about 0.210 inches.

91. An intravascular catheter for infusing and aspirating fluids in the area surrounding the catheter as in claim 75, wherein the catheter has a Shore A durometer in the range from about 45 to about 70.

92. An intravascular catheter for infusing and aspirating fluids in the area surrounding the catheter as in claim 75, further comprising a length of resilient tubing mounted to said catheter and extending along a relatively short distal end segment thereof, the valves being located along the short distal end segment of the catheter to which the tubing is mounted.

93. An intravascular catheter for infusing and aspirating fluids in the area surrounding the catheter as in claim 92, further comprising means defining an aperture in the tubing wall directly opposite and surrounding each valve, each said aperture being wider than its corresponding valve so that tubing wall portions on opposite sides of the slit overhang the opposite edges of the associated aperture.

94. An intravascular catheter for infusing and aspirating fluids in the area surrounding the catheter as in claim 75, wherein the catheter has region subject to compressive forces during infusion and aspiration, the catheter having means positioned within the lumen of the catheter for site-selectively reinforcing the region of the catheter where the compressive forces are applied against the catheter.

95. An intravascular catheter for infusing and aspirating fluids in the area surrounding the catheter as in claim 94, wherein the means for site-selectively reinforcing the catheter comprises an inner tubular sleeve capable of withstanding compressive forces generated by the body of a patient, said inner tubular sleeve being positioned site-selectively within the catheter.

84. An intravascular catheter for infusing and aspirating fluids in the area surrounding the catheter, the catheter comprising:

a close-ended single lumen catheter having a distal end and a proximal end and defining a tubular wall which allows an even flow through the lumen of the catheter, the even flow being initiated when a pressure differential is applied to said catheter; and

two valves in the walls of the catheter comprised of a material for resealing when the pressure differential is withdrawn, the catheter maintaining a predetermined degree of catheter-tip rigidity to maintain structural integrity while the valves consistently and reproducibly open and close to enable infusion and aspiration, the valves comprised of a single, normally closed, linearly extending slit extending through the catheter wall, one of the two slits being radially and longitudinally displaced from the other slit while still providing structural integrity at the distal end of the catheter, the first of the two valves being a primary valve constructed to be preferably operable during aspiration or infusion, the second of the two valves acting as a surrogate to the primary valve should the primary valve fail to operate, the primary valve being treated to be preferably operable to the secondary valve, and wherein the valves are chemically softened with silicone oil.

90. An intravascular catheter for infusing and aspirating fluids in the area surrounding the catheter, the catheter comprising:

a close-ended single lumen catheter having a distal end and a proximal end and defining a tubular wall which allows an even flow through the lumen of the catheter, the even flow being initiated when a pressure differential is applied to said catheter; and

two valves in the walls of the catheter comprised of a material for resealing when the pressure differential is withdrawn, the catheter maintaining a predetermined degree of catheter-tip rigidity to maintain structural integrity while the valves consistently and reproducibly open and close to enable infusion and aspiration, the valves comprised of a single, normally closed, linearly extending slit extending through the catheter wall, one of the two slits being radially and longitudinally displaced from the other slit while still providing structural integrity at the distal end of the catheter, the first of the two valves being a primary valve constructed to be preferably operable during aspiration or infusion, the second of the two valves acting as a surrogate to the primary valve should the primary valve fail to operate, the primary valve being treated to be preferably operable to the secondary valve, and wherein the primary valve is preferable operable to any secondary valve because the primary valve is chemically softened to a greater degree than any secondary valve.