Self-metering fluid analysis device
First Claim
1. A diagnostic device for testing fluid, comprising:
- a housing for containing fluid;
a sample application port defined in the housing for introducing a sample of fluid into the housing;
a metering chamber means positioned in the housing and constructed so as to receive the fluid sample via the sample application port;
a fluid capillary positioned in the housing comprising a first end and a second end wherein the first end is coupled to the metering chamber means for carrying fluid therefrom toward the second end; and
a reaction compartment means positioned in the housing and including;
a first chamber means containing a reagent, anda second chamber means, disposed between the metering chamber means and the first chamber means, containing a filter therein, said filter positioned in flow communication with said metering chamber means;
wherein the filter is positioned and arranged to allow fluid entering the reaction compartment means from the metering chamber means to be filtered and the reagent react with the filtered fluid.
1 Assignment
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Accused Products
Abstract
A diagnostic device detects blood analytes with a sample volume as low as 2 microliters in the hematocrit range of 0% to 60%, or higher. This is accomplished by employing a housing with various chambers and compartments for processing the blood. A sample application port in the housing is used to introduce blood into a metering chamber. From the metering chamber, the blood flows to a reaction chamber for analyzing blood analytes. Blood entering the metering chamber flows into a fluid capillary which indicates that an adequate amount of blood has been received in the metering chamber. The reaction compartment includes a reagent and a filter, the latter of which is disposed between the metering chamber and the reagent so that the reagent reacts with the filtered blood.
312 Citations
18 Claims
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1. A diagnostic device for testing fluid, comprising:
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a housing for containing fluid; a sample application port defined in the housing for introducing a sample of fluid into the housing; a metering chamber means positioned in the housing and constructed so as to receive the fluid sample via the sample application port; a fluid capillary positioned in the housing comprising a first end and a second end wherein the first end is coupled to the metering chamber means for carrying fluid therefrom toward the second end; and a reaction compartment means positioned in the housing and including; a first chamber means containing a reagent, and a second chamber means, disposed between the metering chamber means and the first chamber means, containing a filter therein, said filter positioned in flow communication with said metering chamber means; wherein the filter is positioned and arranged to allow fluid entering the reaction compartment means from the metering chamber means to be filtered and the reagent react with the filtered fluid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A diagnostic device useful for analyzing blood, comprising:
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a housing; a sample application port defined in the housing for introducing blood into the housing; a first metering chamber means positioned in the housing and constructed so as to receive the blood via the sample application port; a first fluid capillary positioned in the housing and comprising a first end and a second end wherein the first end is coupled to the first metering chamber means for carrying blood therefrom and for indicating that an adequate amount of blood has been received in the metering chamber means; a first reaction compartment means positioned in the housing and containing a first reagent and a first filter therein; a second metering chamber means positioned in the housing and that is coupled to the second end of the first fluid capillary for receiving the blood therefrom; a second reaction compartment means positioned in the housing and containing a second reagent and a second filter therein; and a second fluid capillary positioned in the housing and comprising a first end and a second end wherein the first end of said second capillary is coupled to the second metering chamber means for carrying blood therefrom and for indicating that an adequate amount of blood has been received in the second metering chamber means; wherein the first and second filters are positioned and arranged to allow fluid entering the respective first and second reaction compartments means from the respective first and second metering chamber means to be filtered and the first and second reagents react, respectively, with the filtered fluids. - View Dependent Claims (10, 11, 12)
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13. A diagnostic device for analyzing blood, comprising:
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a laminated housing; a sample application port defined in the housing for introducing blood into the housing; a metering chamber means positioned in the housing and constructed so as to receive the blood via the sample application port; a fluid capillary positioned in the housing and comprising a first end that is coupled to the metering chamber means for carrying excess blood therefrom and a second end constructed so as to indicate that an adequate amount of blood has been received in the metering chamber means; a blood containment chamber means, positioned in the housing and in flow communication with the second end of said fluid capillary, for receiving blood therefrom and for preventing spillage of excess blood; a reaction compartment means positioned in the housing and including; an access port, in flow communication with said metering chamber means, for passing blood from said metering chamber means to said reaction compartment means, a filter for filtering the blood that is passed from said metering chamber means, a reagent; and an air capillary, coupled to the reaction compartment means for venting air therefrom; wherein the access port is positioned offset from the sample application port toward the fluid capillary and constructed to allow an adequate amount of blood to fill the metering chamber means before passing through the fluid capillary. - View Dependent Claims (14, 15, 16, 17, 18)
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Specification