Diagnostic testing device

• US 5,149,505 A
• Filed: 07/18/1989
• Issued: 09/22/1992
• Est. Priority Date: 07/18/1989
• Status: Expired due to Fees

• Current Assignee: Abbott Laboratories Incorporated
• Original Assignee: Abbott Laboratories Incorporated
• Inventors: Micek, Stanley E. III, English, Kenneth P., Tripp, Edward S., O'Connell, Michael B.
• Primary Examiner(s): Housel, James C.
• Assistant Examiner(s): Soderquist, Arlen
• Application Number:
  US07/381,360
• Time in Patent Office: 1,162 Days
• Field of Search: 422/64, 422/68.1, 422/50, 422/61, 422/58, 422/102, 422/99, 422/100, 436/808, 435/809, 435/299, 435/300, 435/301, 435/973, 435/975, 222/187
• US Class Current: 422/547
• CPC Class Codes: B01L 3/502 with fluid transport, e.g. in multi-compartment structures centrifugal-type cuvettes G01N21/07; analysis by separation into components G01N30/00; automatic analysers G01N35/00
• CPC Class Codes: G01N 33/54366 Apparatus specially adapted for solid-phase testing
• CPC Class Codes: Y10S 436/808 Automated or kit

Abstract

A diagnostic testing device is disclosed. The testing device includes a base member and a cover member which defines an opening for the reception of a liquid specimen. A distribution wheel delivers portions of the specimen to antibiotic units which are circumferentially spaced. Indicator units are in communication with the cover member. A delivery cylinder extends upwardly from each of the antibiotic units toward a respective one of the indicator units. Relative vertical movement between the delivery cylinder and the indicator unit places the cylinder and the indicator unit into an engaging relationship. A change in coloration at an indicator unit indicates a positive reaction.

Claims

1. A diagnostic testing device comprising, in combination,

a base member defining a cavity, a plurality of antibiotic units within said cavity;

a cover member on said base member, said cover member defining a central cover opening for the reception of a liquid specimen;

a central member positioned between said base member and said cover member, said central member having said plurality of antibiotic units spaced inwardly from its periphery;

distribution means comprising a porous wicking material positioned between said cover opening and said antibiotic units for delivering portions of the liquid specimen to said antibiotic units, said distribution means including a fibrous distribution wheel having a central portion and a plurality of legs extending outwardly from said central portion, said fibrous distribution wheel being positioned on said central member, the outer ends of each of said legs received by a respective one of said antibiotic units;

indicator means in communication with said cover member for indicating the effectiveness of antibiotics;

delivery means comprising a porous wicking material extending upwardly from each of said antibiotic units, whereby relative vertical movement between said delivery means and said indicator means places said delivery means and said indicator means into an engaging relationship, said delivery means including a fibrous cylinder positioned in each of said antibiotic units and extending upwardly toward said cover member; and

means for stably biasing said cover member and said central member in first and second positions relative to each other whereby in said first position said fluid delivery means and indicator means are not in fluid communication with each other and in said second position said fluid delivery means and indicator means are in fluid communication with each other.

2. A diagnostic testing device, according to claim 1, wherein said cover member defines a plurality of indicator stations complementary with said delivery means.

3. A diagnostic testing device, according to claim 1, wherein said distribution means includes a funnel member having an upper end and a lower end.

4. A diagnostic testing device according to claim 1, wherein said distribution means includes a distribution wheel having a central portion and a plurality of legs extending outwardly from said central portion to said antibiotic units.

5. A diagnostic testing device, according to claim 1, wherein each of said antibiotic units comprising a cylindrical member extending upwardly from said central member, said cylindrical antibiotic unit holding an antibiotic disk.

6. A diagnostic testing device, according to claim 1, including a cap for closing said central cover opening in said cover member.

7. A diagnostic testing device, according to claim 6, wherein said cover member defines a neck surrounding said central cover opening, said neck and said cap having locking means for securing said cap to said cover member after said cap is positioned on said neck.

8. A diagnostic testing device, according to claim 6, wherein said base member has a lower surface, such lower surface containing a circular recess, said cap and said circular recess having retaining means for initially holding said cap in said circular recess.

9. A diagnostic testing device, according to claim 1, including hinge means attached to said central member, whereby upward movement of said base member urges said delivery means into engagement with said indicator means.

10. A diagnostic testing device, according to claim 9, wherein said hinge means comprises a living hinge integrally attached at the periphery of said central member and having its outermost edge positioned adjacent said cover member.

11. A diagnostic testing device, according to claim 9, including a tear strip positioned between said cover member and said base member, wherein removal of said tear strip allows relative vertical movement between said cover member and said base member.

12. A diagnostic testing device, according to claim 1, including cam means between said base member and said central member for urging said central member uniformly upwardly relative to said cover member.

13. A diagnostic testing device, according to claim 12, wherein said cam means includes upwardly extending cam members positioned on said base member and cam followers extending downwardly from said central member, whereby rotation of said base member and the resultant movement of the cam members relative to said cam followers urges said central member uniformly upwardly toward said cover member.

14. A diagnostic testing device, according to claim 13, said base member including a circular sidewall, a plurality of slots defined in said sidewall of said base member, a plurality of depending tabs mounted on said central member, said depending tabs having end portions received by said slots, said base member defining locking recesses adjacent the ends of said slots, wherein when said central member is moved by said cam means to said second position, said end portions of said depending tabs are received in said locking recesses.

15. A diagnostic testing device comprising, in combination,

a base member defining a cavity, a central member positioned in said cavity, a plurality of antibiotic units spaced inwardly from the periphery of said center member, each of said antibiotic units including a generally cylindrical member extending upwardly from said central member, said cylindrical member receiving an antibiotic disk;

a cover member on said base member, said cover member defining a central cover opening for the reception of a liquid specimen;

distribution means comprising a porous wicking material positioned between said cover opening and said antibiotic units, said distribution means including a liquid supply conduit extending downwardly from said cover opening and a fibrous distribution member having a central portion in liquid communication with said supply conduit and a plurality of liquid transmission legs extending outwardly from said central portion to said antibiotic units, said fibrous distribution member being positioned on said central member, the outer ends of each of said legs being received by a respective one of said cylindrical members, an antiobiotic disk engaging said cylindrical member adjacent such outer end of said leg;

indicator means in communication with said cover for indicating the effectiveness of antibiotics, wherein said indicator means includes a plurality of indicator stations defined by said cover member;

delivery means including a fibrous cylinder of a porous wicking material positioned in each of said cylindrical members and extending upwardly from each of said antibiotic units toward said cover member, whereby relative vertical movement between said delivery means and said indicator means places said delivery means and said indicator means into an engaging relationship and;

means for stably biasing said cover member and said central member in first and second positions relative to each other whereby in said first position said fluid delivery means and indicator means are not in fluid communication with each other and in said second position said fluid delivery means and indicator means are in fluid communication with each other.

16. A diagnostic testing device, according to claim 15, including hinge means positioned between said central member and said cover member, whereby upward movement of said base member urges said delivery means into engagement with said indicator means.

17. A diagnostic testing device, according to claim 16, wherein said hinge means comprises a living hinge integrally attached at the periphery of said central member and having its outermost edge positioned adjacent said cover member.

18. A diagnostic testing device, according to claim 16, including a tear strip positioned between said cover member and said base member, wherein removal of said tear strip allows relative vertical movement between said cover member and said base member.

19. A diagnostic testing device comprising, in combination,

a base member defining a cavity, a central member positioned in said cavity, a plurality of antibiotic units on said central member;

a cover member on said base member, said cover member defining a central cover opening for the reception of a liquid specimen;

distribution means comprising a porous wicking material positioned between said cover opening and said antibiotic units for delivering portions of the liquid specimen to said antibiotic units;

indicator means in communication with said cover for indicating the effectiveness of antibiotics;

delivery means comprising a porous wicking material extending upwardly from each of said antibiotic units, whereby relative vertical movement between said delivery means and said indicator means places said delivery means and said indicator means into an engaging relationship and;

means for stably biasing said cover member and said central member in first and second positions relative to each other whereby in said first position said fluid delivery means and indicator means are not in fluid communication with each other and in said second position said fluid delivery means and indicator means are in fluid communication with each other.

20. A diagnostic testing device, according to claim 19, wherein said indicator means includes a plurality of indicator stations defined by said cover member.

21. A diagnostic testing device, according to claim 19, wherein said distribution means includes a fibrous distribution wheel having a central portion and a plurality of legs extending outwardly from said central portion to said antibiotic units.

22. A diagnostic testing device, according to claim 21, wherein each of said antibiotic units includes a cylindrical member extending upwardly from said central member, said cylindrical member receiving an antibiotic disk.

23. A diagnostic testing device, according to claim 22, wherein said fibrous distribution wheel is positioned on said central member, the outer ends of each of said legs being received by a respective one of said cylindrical members, an antibiotic disk engaging said cylindrical member adjacent the outer end of the leg, said delivery means including a fibrous cylinder positioned in each of said cylindrical members and extending upwardly toward said cover member.

24. A diagnostic testing device, according to claim 19, including a tear strip positioned between said cover member and said base member, wherein removal of said tear strip allows relative vertical movement between said cover member and said base member.

25. A diagnostic testing device, according to claim 19, including cam means between said base member and said central member for urging said center member uniformly upwardly relative to said cover member.

26. A diagnostic testing device, according to claim 25, wherein said cam means includes upwardly extending cam members positioned on said base member and cam followers extending downwardly from said central member, whereby rotation of said base member and the resultant movement of the cam members relative to said cam followers urges said central member uniformly upwardly toward said cover member.

27. A diagnostic testing device, according to claim 26, said base member including a circular sidewall, a plurality of slots defined in said sidewall of said sidewall, a plurality of depending tabs mounted on said central member, said depending tabs having end portions received by said slots, said base member defining locking recesses adjacent the ends of said slots, wherein when said central member is moved by said cam means to said second position, said end portions of said depending tabs are positioned in said locking recesses.