Use of taurocholic acid and its salts as enhancers for calcitonin containing pharmaceutical compositions
First Claim
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1. A pharmaceutical composition in suppository form useful in reducing calcium levels in the blood and exhibiting enchanced bioavailability of the active ingredient comprising:
- 1) a suppository base;
2) as the active ingredient, a therapeutically effective amount of calcitonin in free base, pharmaceutically acceptable acid addition salt or complex form; and
3) as an enhancer for the calcitonin, from 1% to 4% of taurocholic acid, or a pharmaceutically acceptable salt thereof, based on the total weight of the composition.
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Abstract
Suppositories comprising a suppository base, a calcitonin and taurocholic acid or a pharmaceutically acceptable salt thereof exhibit improved bioavailability and are well tolerated.
26 Citations
20 Claims
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1. A pharmaceutical composition in suppository form useful in reducing calcium levels in the blood and exhibiting enchanced bioavailability of the active ingredient comprising:
- 1) a suppository base;
2) as the active ingredient, a therapeutically effective amount of calcitonin in free base, pharmaceutically acceptable acid addition salt or complex form; and
3) as an enhancer for the calcitonin, from 1% to 4% of taurocholic acid, or a pharmaceutically acceptable salt thereof, based on the total weight of the composition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
- 1) a suppository base;
- 15. A method of enhancing the bioavailability of calcitonin in calcitonin-containing suppositories comprising employing, as the enhancer, from 1% to 4% of taurocholic acid, or a pharmaceutically acceptable salt thereof, based on the total weight of the suppository.
Specification
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Current AssigneeSandoz Inc. (Novartis Ag)
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Original AssigneeSandoz Inc. (Novartis Ag)
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InventorsSteiger, Michel, Azria, Moise
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Primary Examiner(s)Page, Thurman K.
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Assistant Examiner(s)HULINA, AMY
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Application NumberUS07/791,841Time in Patent Office313 DaysField of Search424/433, 424/436, 514/2, 514/21, 514/808, 514/966US Class Current424/436CPC Class CodesA61K 38/23 CalcitoninsA61K 47/28 Steroids, e.g. cholesterol,...A61K 9/02 Suppositories; Bougies; Bas...A61P 3/00 Drugs for disorders of the ...
