Covalent lipid-drug conjugates for drug targeting
First Claim
1. A composition of matter comprising an antiviral or antineoplastic drug, a polar lipid carrier, two linker functional groups and a spacer, wherein the spacer has a first end and a second end and wherein the polar lipid is attached to the first end of the spacer through a first linker functional group and the antiviral or antineoplastic drug is attached to the second end of the spacer through a second linker functional group.
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Reexamination
Accused Products
Abstract
This invention relates to a novel method of drug targeting which comprises covalently binding a drug to a lipid carrier. This composition has the unique ability to both enhance the rate at which an antineoplastic or antiviral drug crosses the plasma membrane, and to direct the drug within the cell to specific organelles. The versatility of these conjugates may be further enhanced by including a spacer group between the drug and the lipid which may act to modulate drug release at the target site.
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Citations
10 Claims
- 1. A composition of matter comprising an antiviral or antineoplastic drug, a polar lipid carrier, two linker functional groups and a spacer, wherein the spacer has a first end and a second end and wherein the polar lipid is attached to the first end of the spacer through a first linker functional group and the antiviral or antineoplastic drug is attached to the second end of the spacer through a second linker functional group.
- 7. A composition of matter comprising an antiviral or antineoplastic drug having a first functional linker group, and a polar lipid carrier having a second functional linker group, wherein the antiviral or antineoplastic drug is covalently linked to the polar lipid carrier by a chemical bond between the first and second functional linker groups.
Specification