Ultra-high-speed extracorporeal ultrasound hyperthermia treatment device

• US 5,150,711 A
• Filed: 07/23/1991
• Issued: 09/29/1992
• Est. Priority Date: 12/14/1983
• Status: Expired due to Term

• Current Assignee: Technomed Medical Systems SA
• Original Assignee: Edap Intl, S.A.
• Inventors: Dory, Jacques
• Primary Examiner(s): Jaworski, Francis
• Assistant Examiner(s): MANUEL, GEORGE C
• Application Number:
  US07/734,667
• Time in Patent Office: 434 Days
• Field of Search: 128/660.03, 128/24 AA, 128/399, 128/804, 128/660.09, 128/660.10
• US Class Current: 600/439
• CPC Class Codes: A61B 17/2258 integrated in a central portion of the shock wave apparatus
• CPC Class Codes: A61B 2017/00154 pulsed
• CPC Class Codes: A61B 2017/22028 arrays, e.g. phased arrays
• CPC Class Codes: A61B 8/08 Detecting organic movements or changes, e.g. tumours, cysts, swellings A61B8/02 - A61B8/06 take precedence
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00
• CPC Class Codes: G01S 15/899 Combination of imaging systems with ancillary equipment

Abstract

An extracorporeal ultra-high-speed ultrasound hyperthermia treatment device adapted to enable focussed emission of ultrasound wave trains at frequencies between 0.5 and 10 MHz with peak powers between 10 kW and a few hundred watts, the parameters which define the concentration of the treatment beam in the focal spot and the power being determined so that, irrespective of the depth and the nature of the tissue, the treatment time is in the order of that enabling significant destruction, preferably total destruction, of the target during the linear part of a curve showing the temperature increase as a function of time.

Claims

1. In an extracorporeal ultrasound hyperthermia target treatment device comprising:

a) means generating a treatment beam from an emitting surface; and

means locating a treatment beam target in a body;

b) means aiming and focusing said beam at said target at a focal spot;

the improvement comprising;

c) in said treatment beam generating means means for producing ultrasound wave trains at frequencies between about 1 MHz and about 6 MHz, as a function of frequency; and

peak electric powers between about 10 KW and 1 KW, as a function of frequency; and

peak acoustic powers between about 3 KW and 200 watts, as a function of frequency;

which produce acoustic intensity at the focal spot between about 100 KW and 10 KW per square centimeter, as a function of frequency, for less than about three seconds.

2. Device according to claim 1 further comprising means for determining the diameter of the emitting surface of said device and the diameter the focal spot are so that the concentration of the whole treatment beam is maximized and the power is is a function of a given value of the frequencies and the diameters determined so that the target is destroyed at a temperature in the vicinity of 58°

C. in a time period between 0.5 and 3 s.

3. Device according to claim 1 wherein the wave trains are separated by periods in the order of 1.5 to 3 s.

4. Device according to claim 1 wherein an emission power on the order of 10 KW corresponds to focal lengths of 10 and 12 cm and a frequency of 1 MHz, an emission power of between 2 and 5 kW corresponds to focal lengths of 3 and 5 cm and frequencies of 3 and 1.5 MHz, respectively, and an emission power on the order of a few hundred watts corresponds to a focal length of 1.5 cm and a frequency of 6 MHz.

5. Device according to claim 1 comprising means for echographic examination of damage to the target during treatment, said examination means executing type B echography of the target and further comprising means to compare two consecutive images taken before and after at least one treatment wave train.

6. Device according to claim 5 comprising display means for storing successive images formed by echographic examination in the form of digital information and for forming differential image by subtracting the stored information point by point.

7. Device according to claim 6 comprising display means for superposing a stored image on the differential image.

8. Device according to claim 1 comprising type A echography means for examining damage to the target during treatment from a type B echography probe to capture echoes at the time the examination beam passes through a predetermined direction and during interruptions of the treatment beam.