Glycoprotein from Avena sativa, process for its preparation, and pharmaceutical compositions containing same
First Claim
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1. An Avena sativa glycoprotein that migrates as a single band during SDS electrophoresis, said glycoprotein having a molecular weight of 38 kD and mitogenic activity.
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Abstract
A glycoprotein with a molecular weight of 38 kD, isolated from the grain of Avena sativa, exhibits surprising pharmacological properties, including immunomodulating activity. The glycoprotein can be used to treat viral and bacterial infections, and can also be used to counter susceptibility to infection arising from a genetic or temporary immunodeficiency. A process for isolating the glycoprotein from Avena sativa is disclosed.
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21 Claims
- 1. An Avena sativa glycoprotein that migrates as a single band during SDS electrophoresis, said glycoprotein having a molecular weight of 38 kD and mitogenic activity.
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8. A process for the preparation of a glycoprotein, comprising the steps of:
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grinding grain of Avena sativa; extracting a glycoprotein from the ground grain; removing constituents having a molecular weight greater than about 5 kD from the extract by filtration; precipitating the constituents having a molecular weight greater than about 5 kD; dissolving the precipitate and removing contaminating salts from the solution by dialysis; separating the components into fractions according to molecular weight; and isolating the 38 kD molecular weight fraction. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16)
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17. An Avena sativa glycoprotein having a molecular weight of 38 kD, said glycoprotein being obtained by a process comprising the steps of:
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grinding grain of Avena sativa; extracting a glycoprotein from the ground grain; removing constituents having a molecular weight greater than about 5 kD from the extract by filtration; precipitating the constituents having a molecular weight greater than about 5 kD; dissolving the precipitate and removing contaminating salts from the solution by dialysis; separating the components into fractions according to molecular weight; and isolating the 38 kD molecular weight fraction. - View Dependent Claims (18, 19, 20, 21)
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Specification