Non-porous coated PTFE graft

• US 5,152,782 A
• Filed: 05/26/1989
• Issued: 10/06/1992
• Est. Priority Date: 05/26/1989
• Status: Expired due to Fees

• Current Assignee: IMPRA Incorporated (Becton, Dickinson & Co)
• Original Assignee: IMPRA Incorporated (Becton, Dickinson & Co)
• Inventors: Farnan, Robert C., Kowligi, Rajagopal R., Colone, William M., Sinnott, Joseph B., Della Corna, Linda V.
• Primary Examiner(s): ISABELLA, DAVID J
• Application Number:
  US07/358,011
• Time in Patent Office: 1,229 Days
• Field of Search: 623/1, 623/11, 623/12
• US Class Current: 623/1.46
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61L 27/16 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/507 for artificial blood vessels apparatus for applying cells on a blood vessel prosthesis A61F2/062
• CPC Class Codes: C08L 27/18 Homopolymers or copolymers or tetrafluoroethene
• CPC Class Codes: C08L 75/04 Polyurethanes
• CPC Class Codes: C08L 83/04 Polysiloxanes

Abstract

A non-porous coated PTFE graft includes a PTFE tube having a conventional porous inner cylindrical wall and a non-porous elastomeric coating applied over at least a portion of the outer cylindrical wall of the PTFE tube to render such portion of the outer cylindrical wall non-porous. The elastomeric coating is made of polyurethane or another biocompatible non-porous elastomer and precludes tissue ingrowth into the outer cylindrical wall, minimizes suture hole bleeding, and increases suture retention strength, while reducing the incidence of serous weepage. The elastomeric coating is preferably applied by mounting the PTFE tube upon a mandrel of like diameter and either dip coating or spray coating all, or selected portions, of the PTFE tube with liquified polyurethane. After the polyurethane coating is completely dried, the non-porous vascular graft is removed form the mandrel and is ready for use.

Claims

1. An implantable vascular graft comprising:

a. an expanded, porous PTFE tube having inner and outer cylindrical walls; and

b. a non-porous coating of a non-porous elastomer applied over at least a portion of the outer cylindrical wall of said PTFE tube, said coating having a substantially uniform thickness.

2. The implantable vascular graft recited by claim 1 wherein said non-porous elastomer coating is a coating of non-porous polyurethane.

3. The implantable vascular graft recited by claim 1 wherein said elastomer is selected from the group of elastomers consisting of medical-grade silicone rubber elastomers, segmented polyurethanes, polyurethane-ureas, and silicone-polyurethane copolymers.

4. An implantable vascular graft comprising:

a. an expanded, porous PTFE tube having inner and outer cylindrical walls, and having first and second opposing end portions and a central portion lying between said first and second opposing end portions; and

b. a non-porous coating of a non-porous elastomer applied over the outer cylindrical wall of said PTFE tube along said first and second opposing end portions but not along the central portion of said PTFE tube.

5. The implantable vascular graft recited by claim 4 wherein said non-porous elastomer coating is a coating of non-porous polyurethane.

6. The implantable vascular graft recited by claim 4 wherein said elastomer is selected from the group of elastomers consisting of medical-grade silicone rubber elastomers, segmented polyurethanes, polyurethane-ureas, and silicone-polyurethane copolymers.

7. An implantable vascular graft comprising:

a. an expanded, porous PTFE tube having inner and outer cylindrical walls;

b. a non-porous coating of a non-porous elastomer applied over at least a portion of the outer cylindrical wall of said PTFE tube but not to the inner cylindrical wall of said PTFE tube, said coating having a substantially uniform thickness; and

c. the inner cylindrical wall of said PTFE tube being uncoated and porous.

8. The implantable vascular graft recited by claim 7 wherein said non-porous elastomer coating is a coating of non-porous polyurethane.

9. The implantable vascular graft recited by claim 7 wherein said elastomer is selected from the group of elastomers consisting of medical-grade silicone rubber elastomers, segmented polyurethanes, polyurethane-ureas, and silicone-polyurethane copolymers.