Medical devices

• US 5,154,165 A
• Filed: 11/26/1991
• Issued: 10/13/1992
• Est. Priority Date: 06/07/1988
• Status: Expired due to Fees

• Current Assignee: British Technology Group Ltd. (Boston Scientific Corporation)
• Original Assignee: National Research Development Corporation
• Inventors: Elliott, Thomas S. J., Byrne, Phillip O.
• Primary Examiner(s): Jaworski, Francis
• Assistant Examiner(s): MANUEL, GEORGE C
• Application Number:
  US07/797,162
• Time in Patent Office: 322 Days
• Field of Search: 128/419 F, 128/419 R, 128/421, 128/787, 128/362, 600/11, 600/13, 600/14, 604/20, 604/21
• US Class Current: 607/2
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: A61M 25/0045 multi-layered, e.g. coated coating materials A61L29/08
• CPC Class Codes: A61N 1/20 continuous direct currents

Abstract

A catheter or other invasive/implant device (40;52) intended for relatively long term use, of the order of a day or more, in a patient'"'"'s body is provided with an electric field generator (48;53) to inhibit bacterial attachment and colonization on and adjacent the device/body interface. The generator can involve application to the device of electret material (53) or an electrode (48) in or for connection with an electrical circuit (47,50,51). The field is preferably unidirectionally negative and also continuous and constant, but pulsatile, alternating and other field forms are possible.

Claims

1. A method of reducing infection arising as a result of a device being at least partially placed within a patient'"'"'s body, said method comprising the steps of:

providing a field generating means comprising two electrodes and a separate power source connected between said electrodes for generating a persistent negative electric field around said device for repelling bacteria; and

while said device is at least partially placed within said body, repelling said bacteria by generating said persistent negative electric field for the order of at least a day, whereby bacterial attachment and colonization in and adjacent the device/body interface is inhibited.

2. A method according to claim 1, wherein one of said electrodes forms at least part of the outer surface of said device to define said interface.

3. A method according to claim 1, wherein one of said electrodes is embedded in said device to follow at least part of the outer surface shape thereof.

4. A method according to claim 1, wherein said field is unidirectionally negative.

5. A method according to claim 4, wherein said field is continuously maintained in a subsequently constant manner.

6. A method according to claim 4, wherein said field is pulsatile.

7. A method according to claim 1, wherein one of said electrodes is intimately connected with said device and the other of said electrodes is connected with said device remotely by way of said power source, said method comprising:

placing said one electrode within said body together with said device to generate said field, and

placing said other electrode on the skin of said body.

8. A method according to claim 7, wherein said power source is a battery having negative and positive terminals and said one and other electrodes are respectively connected to said terminals.

9. A method of reducing infection arising as a result of the presence of a device being at least partially placed within a patient'"'"'s body, said method comprising the steps of:

providing a field generating means comprising an electret material for generating a persistent negative electric field around said device for repelling bacteria; and

while said device is at least partially placed within said body, repelling said bacteria by generating said negative persistent electric field for the order of at least a day, whereby bacterial attachment and colonization in and adjacent the device the device/body interface is inhibited.

10. A method according to claim 9, wherein said electret material forms at least part of the outer surface of said device to define said interface.

11. A method of reducing infection arising as a result of the presence of a device being at least partially placed within a patient'"'"'s body, said method comprising the steps of:

providing a field generating means comprising an electret material for generating a persistent negative electric field around said device for repelling bacteria; and

while said device is at least partially within said body, repelling said bacteria by generating said negative persistent electric field for the order of at least a day as a sole electrical measure for inhibiting bacterial attachment and colonization in and adjacent the device/body interface.

12. A method according to claim 11, wherein said electret material forms at least part of the outer surface of said device to define said interface.

13. A method of reducing infection arising as a result of the presence of a device being at least partially placed within a patient'"'"'s body, said method comprising the steps of:

providing a field generating means comprising two electrodes and a separate power source connected between said electrodes for generating a persistent negative electric field extending around said device for repelling bacteria; and

while said device is at least partially placed within said body, repelling said bacteria by generating said negative persistent electric field for the order of at least a day as a sole electrical measure for inhibiting bacterial attachment and colonization in and adjacent the device/body interface.

14. A method according to claim 13, wherein one of said electrodes forms at least part of the outer surface of said device to define said interface.

15. A method according to claim 13, wherein one of said electrodes is embedded in said device to follow at least part of the outer surface shape thereof.

16. A method according to claim 13, wherein said field is unidirectionally negative.

17. A method according to claim 16, wherein said field is continuously maintained in a substantially constant manner.

18. A method according to claim 16, wherein said field is pulsatile.