Rate adaptive pacemaker controlled by ejection fraction

• US 5,154,171 A
• Filed: 06/15/1991
• Issued: 10/13/1992
• Est. Priority Date: 06/15/1991
• Status: Expired due to Term

• Current Assignee: Dr. Raul Chirife
• Original Assignee: Dr. Raul Chirife
• Inventors: Chirife, Raul
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Getzow, Scott M.
• Application Number:
  US07/714,580
• Time in Patent Office: 486 Days
• Field of Search: 128/419 PG
• US Class Current: 607/24
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance

Abstract

A rate adaptive pacer designed to accommodate changes in a patient'"'"'s metabolic demand utilizes ventricular ejection fraction (EF) as the rate controlling parameter. Ejection fraction is measured by sensing intracardiac impedance at end-diastole and end-systole and then using these measurements to compute stroke volume (SV). Ejection fraction is the stroke volume divided by the end-diastolic volume. This calculated value of EF is processed by the pacemaker to determine the escape interval (pacing rate) through a simple conversion algorithm.

Claims

1. A rate adaptive cardiac pacemaker comprising, in combination:

(a) a pulse generator having timing means for establishing the rate at which cardiac stimulating pulses are produced;

(b) means for applying said stimulating pulses to cardiac tissue;

(c) means for developing a control signal proportional to at least one of residual fraction and ejection fraction of the heart; and

(d) means for applying said control signal to said timing means for varying the rate at which said cardiac stimulating pulses are produced as a function of the heart'"'"'s contractility.

2. The rate adaptive cardiac pacemaker as in claim 1 wherein said means for developing a control signal proportional to the ejection fraction of the heart comprises:

(a) means for developing a first signal proportional to the stroke volume of the heart;

(b) means for developing a second signal proportional to the end-diastolic volume of the heart; and

(c) means for producing said control signal as the ratio of said first signal to said second signal;

(d) means for compensation of non linearity between changes of end-diastolic volumes and end-systolic volumes when metabolic demand is stable.

3. The rate adaptive cardiac pacemaker as in claim 2 wherein said means for developing said first and second signals includes intracardiac impedance sensing means.

4. The rate adaptive cardiac pacemaker as in claim 3 wherein said intracardiac impedance sensing means includes:

(a) means for applying an alternating current carrier voltage of a predetermined frequency between two spaced points in the heart; and

(b) means for sensing instantaneous changes in amplitude of said alternating current carrier voltage due to systolic activity of the heart.

5. The rate adaptive cardiac pacemaker as in claim 4 wherein said means for developing said first signal includes:

(a) means for computing the difference between the maximum and minimum amplitude excursions of said alternating current carrier voltage.

6. The rate adaptive cardiac pacemaker as in claim 4 wherein said means for developing said second signal includes:

(a) means for measuring the minimum amplitude excursions of said alternating current carrier voltage.

7. The rate adaptive cardiac pacemaker as in claim 1 wherein said means for developing a control signal proportional to residual fraction includes:

(a) means for developing a first signal proportional to end-systolic volume of the heart;

(b) means for developing a second signal proportional to the end-diastolic volume of the heart; and

(c) means for dividing said first signal by said second signal.

8. A rate adaptive pacemaker comprising, in combination:

(a) an electronic pulse generator having variable timing means for determining the rate at which cardiac stimulating pulses are produced;

(b) means for applying said pulses to the heart;

(c) means for sensing intracardiac impedance variations occasioned by systolic events;

(d) means responsive to said means for sensing intracardiac impedance for computing the ejection fraction of the heart; and

(e) means for adjusting said timing means in relation to the computed ejection fraction.

9. The rate adaptive pacemaker as in claim 8 wherein said means for computing ejection fraction comprises:

(a) means for sampling the amplitude of the intracardiac impedance upon the occurrence of an R-wave or a cardiac stimulating pulse in the absence of an R-wave to establish end-diastolic volume (EDV);

(b) means for at least temporarily storing a EDV value proportional to the sampled amplitude;

(c) means for sampling the amplitude of the intracardiac impedance at a predetermined time following the occurrence of the R-wave or cardiac stimulating pulse to establish an end-systolic volume value (ESV);

(d) means for subtracting the ESV value from the stored value to determine stroke volume value (SV); and

(e) means for dividing the SV value by the EDV value.

10. The rate adaptive pacemaker as in claim 8 wherein said means for computing ejection fraction comprises:

(a) means for sampling the minimum excursion of said intracardiac impedance variation to establish end-diastolic value (EDV);

(b) means for temporarily storing the EDV value;

(c) means for sampling the maximum excursion of said intracardiac impedance variation to establish an end-systolic volume value (ESV);

(d) means for temporarily storing the ESV value; and

(e) means for computing the ratio (ESV - EDV)/EDV.