Basic fibroblast growth factor
First Claim
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1. Substantially pure mammalian basic fibroblast growth factor (FGF) containing the amino acid sequence:
- ##STR4## or a naturally occurring homologous sequence of another mammalian species, which growth factor is effective to stimulate proliferation of endothelial cells in vitro.
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Abstract
Substantially pure mammalian basic fibroblast growth factors are produced. The amino acid residue sequences of bovine and human bFGF are disclosed as well as a DNA chain encoding the polypeptide of the bovine species. By appropriately inserting a synthesized DNA chain into a cloning vector and using the cloning vector to transform cells, synthetic bFGF can be obtained from transformed cell lines, both prokaryotic and eukaryotic.
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3 Claims
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1. Substantially pure mammalian basic fibroblast growth factor (FGF) containing the amino acid sequence:
- ##STR4## or a naturally occurring homologous sequence of another mammalian species, which growth factor is effective to stimulate proliferation of endothelial cells in vitro.
- View Dependent Claims (2, 3)
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