Emission-transmission imaging system using single energy and dual energy transmission and radionuclide emission data

• US 5,155,365 A
• Filed: 07/09/1990
• Issued: 10/13/1992
• Est. Priority Date: 07/09/1990
• Status: Expired due to Term

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Gingold, Eric L., Cann, Christopher E., Hasegawa, Bruce H.
• Primary Examiner(s): FIELDS, CAROLYN
• Application Number:
  US07/549,890
• Time in Patent Office: 827 Days
• Field of Search: 378/4, 378/5, 378/156, 250/363.03, 250/363.04, 250/370.06
• US Class Current: 250/363.02
• CPC Class Codes: A61B 6/037 Emission tomography
• CPC Class Codes: A61B 6/4241 using energy resolving detectors, e.g. photon counting
• CPC Class Codes: G01T 1/1615 using both transmission and emission sources simultaneously SPECT imaging G01T1/1642; PET imaging G01T1/2985; detecting prohibited goods, e.g. weapons, explosives, hazardous substances, contraband or smuggled objects G01V5/20
• CPC Class Codes: G01T 1/1642 using a scintillation crystal and position sensing photodetector arrays, e.g. ANGER cameras
• CPC Class Codes: G01T 1/1647 Processing of scintigraphic data not related to a particular imaging system G01T1/2992
• CPC Class Codes: G01T 1/1648 Ancillary equipment for scintillation cameras, e.g. reference markers, devices for removing motion artifacts, calibration devices adapted for flow studies G01T1/1647
• CPC Class Codes: H05G 1/60 Circuit arrangements for obtaining a series of X-ray photographs or for X-ray cinematography

Abstract

Radionuclide emission imaging is improved by correcting emission transmission data for attenuation along calculated path lengths and through calculated basis material. Single or dual energy projector data can be simultaneously obtained with radionuclide emission data to improve localization of radionuclide uptake. Dual energy x-ray projection techniques are used to calculate the path lengths and basis material (bone, tissue, fat). The radionuclide emission data and the transmitted x-ray data are simultaneously obtained using an energy selective photon detector whereby problems of misregistration are overcome. The dual-energy x-ray projection data are utilized to determine material-specific properties and are recombined into an effectively monoenergetic image, eliminating inaccuracies in material property estimation due to beam hardening. Use of a single instrument for simultaneous data collection also reduces technician time and floor space in a hospital.

Claims

1. An emission-transmission imaging system comprising

a) an x-ray source for emitting a low energy x-ray spectrum and a high energy x-ray spectrum,

b) detector means for simultaneously and selectively detecting photons corresponding to said low energy x-ray spectrum and said high energy x-ray spectrum and photons corresponding to radionuclide emission,

c) means for positioning said x-ray source facing said detector means with an object positionable therebetween, said object having a radionuclide therein,

d) data acquisition means connected with said detector means for receiving signals from said detector means representative of detected low energy x-ray spectrum photons, high energy x-ray spectrum photons, and radionuclide emission photons,

e) computer means for receiving and processing said signals and producing image signals of distribution of a radionuclide in said object based on emission photon data as corrected for material-specific attenuation derived from dual energy x-ray transmission data, and

f) display means responsive to said image signals.

2. The emission-transmission imaging system as defined by claim 1 wherein said x-ray source comprises an x-ray tube and a rare earth filter.

3. The emission-transmission imaging system as defined by claim 2 wherein said detector means comprises an array of multielement high speed detectors and said data acquisition means comprises a plurality of x-ray windows and counters.

4. The emission-transmission imaging system as defined by claim 3 wherein each detector element is selected from the group consisting of germanium, cadmium telluride, lead iodide, and mercuric iodide.

5. The emission-transmission imaging system as defined by claim 2 wherein said detector means comprises a plurality of stacked collinear detectors.

6. The emission-transmission imaging system as defined by claim 5 wherein said collinear detectors comprise sodium iodide.

7. The emission-transmission imaging system as defined by claim 6 wherein one collinear detector is current integrating and is responsive to a switched x-ray source, another detector is pulse counting and responsive to radionuclide emission.

8. A method of providing an improved radionuclide emission image comprising the steps of

providing a multiple energy x-ray source,

providing detector means for simultaneously and selectively detecting photons corresponding to multiple energies from said x-ray source and photons from radionuclide emission,

positioning a body having a radionuclide therein between said source and said detector means,

simultaneously detecting photons from said x-ray source and from said radionuclide and generating signals indicative thereof,

determining path lengths for basic materials for photons from radionuclide emission based on data from detected photons from said x-ray source,

correcting radionuclide emission data based on attenuation thereof through said path lengths, for said basis materials, and

displaying a radionuclide emission image based on the corrected radionuclide data.

9. The method as defined by claim 8 wherein said basis materials are equivalent to soft tissue and bone.

10. The method as defined by claim 8 and further including the step of reconstructing a basis material image using signals from detected photons from said x-ray source.

11. The method as defined by claim 10 wherein said step of reconstructing a basis material image utilizes dual energy reconstruction techniques.

12. The method as defined by claim 11 wherein said dual energy reconstruction techniques include obtaining bone cancelled data and tissue cancelled data from which equivalent constituent fractions of tissue and bone are derived.

13. In radionuclide emission imaging, a method of correcting radionuclide emission data for an improved image comprising the steps of

simultaneously and selectively obtaining radionuclide emission data from a body and multiple energy x-ray transmission data from x rays passed through said body,

determining basis material path lengths from said multiple energy x-ray transmission data, and

correcting said radionuclide emission data based on attenuation of radionuclide emission along said basis material path lengths.

14. The method as defined by claim 13 wherein dual energy reconstruction techniques are utilized to determine bone cancelled data and tissue cancelled data from which equivalent fractions of tissue and bone are derived.

15. The method as defined by claim 13 wherein said step of determining basis material path lengths includes dual energy CT reconstruction.