Variable rate pacemaker having upper rate limit governor based on hemodynamic performance

• US 5,156,147 A
• Filed: 02/05/1991
• Issued: 10/20/1992
• Est. Priority Date: 02/05/1991
• Status: Expired due to Term

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Warren, Jay A., Millerhagen, Jay O., Spinelli, Julio C.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): MANUEL, GEORGE C
• Application Number:
  US07/651,318
• Time in Patent Office: 623 Days
• Field of Search: 128/419 PG, 128/419 P, 128/419 D, 128/734
• US Class Current: 607/24
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

A rate adaptive pacemaker of the type having a variable rate cardiac stimulating pulse generator and a sensor for monitoring some physiologic parameter whereby the pulse generator stimulating rate can be adjusted to meet physiologic demand is further provided with a hemodynamic sensor which is operative to provide an output signal representing the pumping performance of the heart in response to the pacing stimulation. The signal from the hemodynamic sensor is processed and then used in an algorithm to determine whether further rate increase should be permitted based upon whether the rate increase would be accompanied by a further increase in cardiac output, a plateau or a decrease in cardiac output. Hence, the adaptive rate pacemaker is provided with a real-time, hemodynamic maximum pacing rate instead of a preprogrammed, fixed, maximum rate.

Claims

1. In a rate adaptive pacemaker of the type including a variable rate pulse generating means for producing cardiac stimulating pulses, means for sensing a change in a patient'"'"'s physiologic demand, mans responsive to said sensed change in physiologic demand for providing a control signal to said variable rate pulse generating means to thereby alter the rate at which said stimulating pulses are produced by said variable rate pulse generating means, the improvement comprising:

(a) means for sensing changes in the hemodynamic performance of the heart in response to said stimulating pulses; and

(b) means responsive to said means for sensing changes in the hemodynamic performance for preventing said control signal from altering the rate at which said stimulating pulses are produced by said pulse generating means when to do so will compromise said hemodynamic performance of the heart.

2. The rate adaptive pacemaker as in claim 1 wherein said means for sensing changes in hemodynamic performance includes mans for measuring changes in right ventricular impedance.

3. The rate adaptive pacemaker as in claim 1 wherein said means for sensing changes in hemodynamic performance senses stroke volume.

4. The rate adaptive pacemaker as in claim 1 wherein said means for sensing changes in hemodynamic performance includes cardiac output sensing means.

5. The rate adaptive pacemaker as in claim 4 wherein said means for preventing inhibits said control signal from increasing the rate at which said stimulating pulses are produced when said cardiac output sensing means indicates that such a rate increase fails to cause a corresponding increase in cardiac output.

6. The rate adaptive pacemaker as in claim 1 wherein said means for sensing changes in hemodynamic performance includes means for measuring arterial pressures.

7. The rate adaptive pacemaker as in claim 1 wherein said means for sensing changes in hemodynamic performance includes means for means for measuring the pre-ejection interval of the cardiac cycle.

8. In a rate adaptive pacemaker of the type including a variable rate pulse generating means for producing cardiac stimulating pulses, means for sensing a change in physiologic demand, means responsive to said sensed change for providing a first control signal to said variable rate pulse generating means for varying the rate at which said stimulating pulses are produced thereby, the improvement comprising:

(a) means coupled to said pulse generating means and automatically responsive to the hemodynamic performance of the heart for limiting the upper rate to which said stimulating pulses can be driven by said first control signal.

9. The rate adaptive pacemaker as in claim 8 wherein said means for limiting the upper rate at which said stimulating pulses can be driven comprises:

(a) further means for sensing when an increase in stimulating rate is accompanied by a decrease in cardiac output; and

(b) means responsive to said further sensing means for inhibiting a further increase in said stimulating rate.

10. The rate adaptive pacemaker as in claim 9 wherein said means for limiting comprises:

(a) mans for sensing cardiac output of the heart and producing a second control signal proportional thereto; and

(b) logic means coupled to receive said first and second control signals for inhibiting said first control signal when said first control signal is determined to be in a direction to increase the stimulation rate when said second control signal is indicative of a decrease in cardiac output.

11. The rate adaptive pacemaker as in claim 10 wherein said means for sensing physiologic demand senses a different parameter than said means for sensing cardiac output.

12. The rate adaptive pacemaker as in claim 8 wherein said means for limiting comprises:

(a) logic means for detecting when the rate of change of cardiac output with respect to stimulation pulse rate drops below a predetermined slope value; and

(b) means responsive to said logic means for inhibiting said first control signal from increasing said stimulation pulse rate.

13. The rate adaptive pacemaker as in claim 8 wherein said means for limiting comprises:

(a) means for sensing physiologic demand for controlling stimulation pulse rate;

(b) means for sensing hemodynamic performance; and

(c) means responsive to said hemodynamic performance for inhibiting said first control signal from increasing said stimulation pulse rate.