Skin electrode construction and transdermal drug delivery device utilizing same

• US 5,156,591 A
• Filed: 12/13/1990
• Issued: 10/20/1992
• Est. Priority Date: 12/13/1990
• Status: Expired due to Term

• Current Assignee: Elan Medical Technologies (E.M.T.) Israel Limited, Elan Medical Technologies (Ireland) Ltd. (Perrigo Company PLC), Scientific Innovations Limited
• Original Assignee: S.I. Scientific Innovations, Ltd.
• Inventors: Zucker, Shlomo, Gross, Joseph
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): JASTRZAB, JEFFREY R
• Application Number:
  US07/627,104
• Time in Patent Office: 677 Days
• Field of Search: 604/20, 604/290, 128/798, 128/802, 128/803
• US Class Current: 604/20
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61N 1/303 Constructional details electrodes for external use A61N1/0428

Abstract

A transdermal drug delivery device includes an electrode, a porous insulating layer on one side of the electrode and impregnated with a liquid containing the drug to be delivered, a reservoir for the liquid on the other side of the electrode, and a displaceable diaphragm controlling the feeding of the liquid from the reservoir to the porous insulating layer via a passageway through the electrode.

Claims

1. An electrical device for application to a subject'"'"'s skin, including an electrode and a porous insulating layer thereover impregnated with a liquid to be placed in contact with the subject'"'"'s skin in order to reduce or eliminate skin irritation or skin burn;

characterized in that said device includes;

a reservoir for said liquid in communication with said porous insulating layer;

a displaceable member controlling the feeding of said liquid from the reservoir to said porous insulating layer;

and control means for controlling said displaceable member and thereby the feeding of the liquid from the reservoir to said porous insulating layer so as to reduce or eliminate skin irritation or skin burn.

2. The device according to claim 1, wherein said displaceable member is a diaphragm, and said control means includes a pressure chamber and means for controlling the pressure in said chamber for controlling the displacement of said diaphragm.

3. The device according to claim 2, wherein said pressure chamber includes an electrolytic cell capable of generating a gas corresponding to the electric current applied to the electrolytic cell.

4. The device according to claim 3, wherein said porous insulating layer includes a sensor sensing the liquid content of the porous insulating layer, and said control means includes a control circuit controlled by said sensor for controlling the electric current applied to said electrolytic cell in response to the sensed liquid content of the porous insulating layer.

5. The device according to claim 1, wherein said porous insulating layer is circumscribed by a sealing ring to be contacted by the subject'"'"'s skin.

6. The device according to claim 5, wherein said pressure chamber further includes a pressure sensor sensing the pressure therein and controlling said control means in response thereto.

7. The device according to claim 1, wherein said reservoir is configured to receive a bag of the liquid on one side of the porous insulating layer, said device further including a piercing element for piercing the bag when the device is to be used for transdermal delivery of the liquid.

8. The device according to claim 1, further including a second electrode and a voltage source connected to the electrodes for controlling the delivery of a drug by iontophoresis.

9. The device according to claim 1, wherein there are a pair of said porous insulating layers, each including an electrode, a reservoir, and a displaceable diaphragm for controlling the feed of the liquid from each reservoir via its respective electrode to its respective porous insulating layer.

10. A transdermal drug delivery device for delivering a liquid drug to a subject, comprising:

a porous insulating layer having means for attaching the device to a subject with one side of the porous insulating layer in contact with the subject'"'"'s skin;

a reservoir on an opposite side of the porous insulating layer for a liquid drug to be delivered;

a displaceable diaphragm controlling the feeding of the liquid drug from the reservoir to the porous insulating layer;

and control means including a pressure chamber having an electrolytic cell capable of generating a gas corresponding to electric current applied to the electrolytic cell for controlling said displaceable member and thereby the rate of feed of the liquid from the reservoir to said porous insulating layer.

11. The device according to claim 10, wherein said porous insulating layer includes a sensor sensing the liquid content thereof, and said control means further includes a control circuit controlled by said sensor for controlling the electric current applied to said electrolytic cell in response to said sensed liquid content of porous insulating layer.

12. A transdermal drug delivery device, for delivering a drug to a subject, comprising:

first and second electrodes each covered on one side by a porous insulating layer impregnated with a liquid to be placed in contact with the subject'"'"'s skin;

a reservoir for each liquid on the other side of each electrode in communication with the porous insulating layer thereof, at least one liquid including a drug to be transdermally delivered to the subject;

each of said reservoirs including a displaceable member controlling the feed of the liquid from its respective reservoir to the porous insulating layer of its respective electrode;

and control means for controlling said displaceable members, and thereby the rate of feed of the liquid, from each reservoir to the porous insulating layer of its respective electrode.

13. The device according to claim 12, wherein each of said displaceable members is a diaphragm, and said control means includes a pressure chamber for each diaphragm controlling the displacement thereof.

14. The device according to claim 13, wherein each of said pressure chambers includes an electrolytic cell capable of generating a gas corresponding to the electric current applied to the electrolytic cell.

15. The device according to claim 14, wherein each of said porous insulating layers includes a sensor sensing the liquid content of the respective porous insulating layer, said control means including a control circuit controlled by each of said sensors for controlling the electric current applied to the electrolytic cell of its respective electrode automatically in response to the sensed liquid content of the respective porous insulating layer.

16. The device according to claim 15, wherein both of said electrodes, porous insulating layers, and diaphragms, are carried by a band adapted to be applied to the arm or leg of the subject.

17. The device according to claim 12, wherein both of said electrodes, their porous insulating layers, and their reservoirs, are disposed in side-by-side relation.

18. The device according to claim 12, wherein there are a plurality of sections of said first electrode covered by sections of said porous insulating layer in spaced relation with respect to each other, said second electrode and its porous insulating layer occupying spaces between said sections of the first electrode.