Liquid suspension for oral administration
First Claim
1. A non-aqueous pharmaceutical liquid suspension having improved bioavailability for oral administration comprising an antibiotic suspended in an edible, non-aqueous carrier vehicle wherein the antibiotic is in the form of controlled release microparticles containing the antibiotic and optionally an excipient, the antibiotic of said microparticles being coated with, distributed through or adsorbed onto at least one non-toxic polymer, and said microparticles further having an average size in the range 0.1 to 150 microns and a controlled rate of release of antibiotic which in combination with the non-aqueous carrier vehicle permits controlled absorption of antibiotic effective to improve the bioavailability of said antibiotic over that obtained in aqueous liquid suspensions.
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Accused Products
Abstract
A non-aqueous pharmaceutical liquid suspension having improved bioavailability for oral administration comprises an active ingredient suspended in an edible, non-aqueous carrier vehicle such as an oil, wherein the active ingredient is in the form of controlled release particles containing the active ingredient and optionally an excipient in intimate admixture with at least one non-toxic polymer, the particles being coated with, distributed through or adsorbed onto said polymer, and the particles further having an average size in the range 0.1 to 150 microns and a predetermined release of active ingredient.
48 Citations
10 Claims
- 1. A non-aqueous pharmaceutical liquid suspension having improved bioavailability for oral administration comprising an antibiotic suspended in an edible, non-aqueous carrier vehicle wherein the antibiotic is in the form of controlled release microparticles containing the antibiotic and optionally an excipient, the antibiotic of said microparticles being coated with, distributed through or adsorbed onto at least one non-toxic polymer, and said microparticles further having an average size in the range 0.1 to 150 microns and a controlled rate of release of antibiotic which in combination with the non-aqueous carrier vehicle permits controlled absorption of antibiotic effective to improve the bioavailability of said antibiotic over that obtained in aqueous liquid suspensions.
Specification