Skin-activated temperature-sensitive adhesive assemblies

• US 5,156,911 A
• Filed: 05/11/1989
• Issued: 10/20/1992
• Est. Priority Date: 05/11/1989
• Status: Expired due to Term

• Current Assignee: Landec Corporation
• Original Assignee: Landec Labs Incorporated
• Inventors: Stewart, Ray F.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): Horne, Leon R.
• Application Number:
  US07/350,723
• Time in Patent Office: 1,258 Days
• Field of Search: 428/444, 428/455, 428/355, 428/343, 424/448, 424/449
• US Class Current: 428/355.0AC
• CPC Class Codes: A61L 15/585 Mixtures of macromolecular compounds
• CPC Class Codes: B05B 12/24 made at least partly of flexible material, e.g. sheets of paper or fabric
• CPC Class Codes: C08L 33/04 Homopolymers or copolymers of esters C08L43/04 takes precedence
• CPC Class Codes: C09J 133/06 of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
• CPC Class Codes: C09J 7/35 Heat-activated
• CPC Class Codes: Y10T 428/2891 including addition polymer from alpha-beta unsaturated carboxylic acid [e.g., acrylic acid, methacrylic acid, etc.] Or derivative thereof

Abstract

An adhesive assembly is provided having a temperature-sensitive adhesive composition coated on the surface of a selected substrate. The adhesive composition is nontacky or slightly tacky at room temperature, but is aggressively tacky at skin temperature. The assemblies include adhesive tapes, bandages, films and the like.

Claims

1. A temperature-sensitive adhesive assembly for application to the skin, comprising a body member having a surface coated with a polymeric adhesive composition which is substantially nontacky at or below about 25°

C. and which becomes tacky upon contact with the skin, wherein the adhesive composition comprises a side-chain crystallizable polymer having a heat of fusion that is greater than about 20 Joules/g, and a melting point or first-order transition temperature in the range of about 20°

C. to 35°

C., and wherein the side-chain crystallizable polymer contains at least about 50% monomer units of the structure ##STR3## wherein M is a backbone atom and --S--C is a side-chain in which S is a spacer unit and C is a crystallizable group, and wherein the length of the side-chain is greater than five times the distance between adjacent side-chains in the polymer, and wherein the body member is a flexible backing, a cast, a splint, a transdermal drug delivery device, a bandaid, a medicated bandaid, a surgical dressing, or an EKG electrode.

2. The adhesive assembly of claim 1, wherein the side-chain crystallizable polymer has a melting point or first-order transition temperature in the range of about 25°

C. to 30°

C.

3. The adhesive assembly of claim 1, wherein the side-chain crystallizable polymer comprises at least 50 wt. % monomer units selected from the group consisting of:

linear aliphatic C₁₄ -C₂₂ acrylates and methacrylates;

linear aliphatic C₁₄ -C₂₂ acrylamides and methacrylamides;

vinyl ethers and esters;

siloxanes; and

alpha olefins.

4. The adhesive assembly of claim 1 comprising temperature-sensitive adhesive tape, wherein the body member is a flexible backing.

5. The adhesive assembly of claim 1 comprising a temperature-sensitive adhesive sheet.

7. The adhesive assembly of claim 1, wherein the freezing point is in the range of about 15°

C. to 25°

C.

12. The adhesive assembly of claim 1, wherein the melting point or first-order transition temperature is in the range of about 25°

C. to 30°

C. and the freezing point is in the range of about 15°

C. to 25°

C.

6. A temperature-sensitive adhesive assembly for application to the skin which is readily removable therefrom upon cooling, comprising a body member having a surface coated with a polymeric adhesive composition comprising a side-chain crystallizable polymer which has a heat of fusion that is greater than about 20 Joules/g, and a freezing point in the range of about 10°

C. to about 28°

C., and wherein the side-chain crystallizable polymer contains at least about 50% units of the structure ##STR4## wherein M is a backbone atom, S is a spacer unit, and C is a crystallizable group and wherein the body member is a flexible backing, a the length of the side chains is greater than 5 times the distance between adjacent side chains in the polymer cast, a splint, a transdermal drug delivery device, a bandaid, a medicated bandaid, a surgical dressing, or an EKG electrode.

8. The adhesive assembly of claim 6, wherein the side-chain crystallizable polymer comprises at least 50 wt. % monomer units selected from the group consisting of:

linear aliphatic C₁₄ -C₂₂ acrylates and methacrylates;

linear aliphatic C₁₄ -C₂₂ acrylamides and methacrylamides;

vinyl ethers and esters;

siloxanes; and

alpha olefins.

9. The adhesive assembly of claim 6 comprising temperature-sensitive adhesive tape, wherein the body member is a flexible backing.

10. The adhesive assembly of claim 6 comprising a temperature-sensitive adhesive sheet.

11. A temperature-sensitive adhesive assembly for application to the skin which is readily removable therefrom upon cooling, comprising a body member having a surface coated with a polymeric adhesive composition which is substantially nontacky at or below about 25°

C. and which becomes tacky upon contact with the skin, comprising a side-chain crystallizable polymer having a heat of fusion of greater than about 20 Joules/g and which has a melting point or first-order transition temperature in the range of about 20°

C. to 35°

C. and a freezing point in the range of about 10°

C. to 28°

C., and wherein the side-chain crystallizable polymer contains at least 50% monomer units of the structure ##STR5## wherein M is a backbone atom, S is a spacer unit, and C is a crystallizable group, and wherein the body member is a flexible backing, a the length of the side chain is greater than 5 times the distance between adjacent side chains in the polymer cast, a splint, a trandermal drug delivery device, a bandaid, a medicated bandaid, a surgical dressing, or an EKG electrode.

13. The adhesive assembly of claim 11, wherein the side-chain crystallizable polymer comprises at least 50 wt. % monomer units selected from the group consisting of:

linear aliphatic C₁₄ -C₂₂ acrylates and methacrylates;

linear aliphatic C₁₄ -C₂₂ acrylamides and methacrylamides;

vinyl ethers and esters;

siloxanes; and

alpha olefins.

14. The adhesive assembly of claim 11 comprising temperature-sensitive adhesive tape, wherein the body member is a flexible backing.

15. The adhesive assembly of claim 11 comprising a temperature-sensitive adhesive sheet.

16. A temperature-sensitive adhesive assembly for application to the skin which is readily removable therefrom upon cooling, comprising a body member having a surface coated with a polymeric adhesive composition which is substantially nontacky at or below about 25°

C. and which becomes tacky upon contact with the skin, comprising a side-chain crystallizable polymer having a heat of fusion of greater than about 20 Joules/g and a melting point or first-order transition temperature in the range of about 20°

C. to 35°

C. and a freezing point in the range of about 10°

C. to 28°

C.,

wherein the side-chain crystallizable polymer comprises at least 50 wt. % monomer units selected from the group consisting of;

linear aliphatic C₁₄ -C₂₂ acrylates and methacrylates;

linear aliphatic C₁₄ -C₂₂ acrylamides and methacrylamides;

vinyl ethers and esters;

siloxanes; and

alpha olefins, and wherein the body member is a flexible backing, a cast, a splint, a transdermal drug delivery device, a bandaid, a medicated bandaid, a surgical dressing, or an EKG electrode.

17. The adhesive assembly of claim 16, wherein the side-chain crystallizable polymer comprises at least 50 wt. % monomer units selected from the group consisting of linear aliphatic C₁₄ -C₂₂ acrylates and methacrylates.

18. A temperature-sensitive adhesive assembly for application to the skin, comprising a body member having a surface coated with a polymeric adhesive composition which is substantially nontacky at or below about 25°

C. and which becomes tacky upon contact with the skin, wherein the adhesive composition comprises a main-chain crystallizable polymer having a heat of fusion that is greater than about 20 Joules/g, and a melting point or first-order transition temperature in the range of about 20°

C. to 35°

C., and wherein the main-chain crystallizable polymer is selected from the group consisting of a water-insoluble polyethylene oxide, a lower alkyl polyester, and polytetrahydrofuran, and wherein the body member is a flexible backing, a cast, a splint, a transdermal drug delivery device, a bandaid, a medicated bandaid, a surgical dressing, or an EKG electrode.

19. A temperature-sensitive adhesive assembly for application to the skin which is readily removable therefrom upon cooling, comprising a body member having a surface coated with a polymeric adhesive composition comprising a main-chain crystallizable polymer which has a heat of fusion that is greater than about 20 Joules/g, and a freezing point in the range of about 10°

C. to about 28°

C., and wherein the main-chain crystallizable polymer is selected from the group consisting of a water-insoluble polyethylene oxide, a lower alkyl polyester, and polytetrahydrofuran, and wherein the body member is a flexible backing, a cast, a splint, a transdermal drug delivery device, a bandaid, a medicated bandaid, a surgical dressing, or an EKG electrode.

20. A temperature-sensitive adhesive assembly for application to the skin which is readily removable therefrom upon cooling, comprising a body member having a surface coated with a polymeric adhesive composition which is substantially nontacky at or below about 25°

C. and which becomes tacky upon contact with the skin, comprising a main-chain crystallizable polymer having a heat of fusion of greater than about 20 Joules/g and which has a melting point or first-order transition temperature in the range of about 20°

C. to 35°

C. and a freezing point in the range of about 10°

C. to 28°

C., and wherein the main-chain crystallizable polymer is selected from the group consisting of a water-insoluble polyethylene oxide, a lower alkyl polyester, and polytetrahydrofuran, and wherein the body member is a flexible backing, a cast, a splint, a transdermal drug delivery device, a bandaid, a medicated bandaid, a surgical dressing, or an electrode.