Regulating peritoneal lymphatic drainage and uses therefor
First Claim
1. A method for blocking lymphatic drainage of the peritoneal cavity of a living mammal comprising the step of introducing into said peritoneal cavity an aqueous dispersion of biodegradable, substantially non-toxic, initially substantially water-insoluble particles that slowly become partially or fully dissolved in the peritoneal cavity or in the lymphatic ducts of said mammal, said particles comprised of at least one material selected from the group consisting of polysaccharides, cellulose and cellulose derivatives, fibrous proteins, plasma proteins, dextran, lactin, polypeptides, polyamino acids, polyesters, polyamides, polyanhydrides, poly(ortho ester), polyacrylates, poly(cyano acrylates), polyvinyl pyrrolidone, phospholipids, polystyrene and polymethylmethacrylate, said particles individually having an average size of about 15 to 150 microns in their shortest cross-section wherein the total number of said particles introduced is at least equal to the estimated number of lymphatic stomata in said peritoneal cavity.
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Abstract
A method for blocking lymphatic drainage of the peritoneal cavity of a living mammal by introducing into such cavity particles in the range from about 15 to 150 micron in their shortest cross section which particles are substantially non-toxic and initially substantially water-insoluble. The method can be practiced in combination with peritoneal dialysis or with pharmaceutical agent administration into the peritoneum. Compositions suitable for use in such particle administration are provided.
30 Citations
25 Claims
- 1. A method for blocking lymphatic drainage of the peritoneal cavity of a living mammal comprising the step of introducing into said peritoneal cavity an aqueous dispersion of biodegradable, substantially non-toxic, initially substantially water-insoluble particles that slowly become partially or fully dissolved in the peritoneal cavity or in the lymphatic ducts of said mammal, said particles comprised of at least one material selected from the group consisting of polysaccharides, cellulose and cellulose derivatives, fibrous proteins, plasma proteins, dextran, lactin, polypeptides, polyamino acids, polyesters, polyamides, polyanhydrides, poly(ortho ester), polyacrylates, poly(cyano acrylates), polyvinyl pyrrolidone, phospholipids, polystyrene and polymethylmethacrylate, said particles individually having an average size of about 15 to 150 microns in their shortest cross-section wherein the total number of said particles introduced is at least equal to the estimated number of lymphatic stomata in said peritoneal cavity.
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9. An improved method for conducting peritoneal dialysis comprising the steps of:
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A. introducing into the peritoneal cavity of a living mammal water dispersable, biodegradable, substantially non-toxic, initially substantially water-insoluble particles that slowly become partially or fully dissolved in the peritoneal cavity or in the lymphatic ducts of said mammal, said particles comprised of at least one material selected from the group consisting of polysaccharides, cellulose and cellulose derivatives, fibrous proteins, plasma proteins, dextran, lactin, polypeptides, polyamino acids, polyesters, polyamides, polyanhydrides, poly(ortho esters), polyacrylates, poly(cyano acrylates), polyvinyl pyrrolidone, phospholipids, polystyrene and polymethylmethacrylate, said particles individually having an average size in the range from about 15 to 150 microns in their shortest cross-section wherein the total number of said particles introduced is at least equal to the estimated number of lymphatic stomata in said peritoneal cavity; B. introducing into said peritoneal cavity a peritoneal dialysis fluid; C. retaining the resulting mixture of said fluid and said dispersion in said peritoneal cavity for a time period which is at lest sufficient to achieve urea removal from said mammal through said mammal'"'"'s peritoneum and into said resulting mixture in said peritoneal cavity; and D. removing said resulting mixture from said peritoneal cavity. - View Dependent Claims (10, 11, 12, 13)
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14. A method for administering a pharmaceutical agent into a living mammal comprising the steps of:
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A. introducing into the peritoneal cavity of a living mammal water dispersable, biodegradable, substantially non-toxic, initially substantially water-insoluble particles that slowly become partially or fully dissolved in the peritoneal cavity or in the lymphatic ducts of said mammal, said particles comprised of at least one material selected from the group consisting of polysaccharides, cellulose and cellulose derivatives, fibrous proteins, plasma proteins, dextran, lactin, polypeptides, polyamino acids, polyesters, polyamides, polyanhydrides, poly(ortho esters), polyacrylates, poly(cyano acrylates), polyvinyl pyrrolidone, phospholipids, polystyrene and polymethylmethacrylate, said particles individually having an average size in range from about 15 to 150 microns in their shortest cross section wherein the total number of said particles introduced is at least equal to the estimated number of lymphatic stomata in said peritoneal cavity; and B. introducing into said peritoneal cavity a pharmaceutical agent in an amount at least sufficient to provide a pharmaceutically effective does of said agent for said mammal;
said pharmaceutical agent being in a form which is absorbable by said mammal through said mammal'"'"'s peritoneum. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21)
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- 22. A composition adapted for introduction into the peritoneal cavity of a living mammal and which, when so-introduced into such a peritoneal cavity as a unit dose, is adapted to reduced lymphatic drainage from such peritoneal cavity, said composition comprising water which has dispersed therein per unit dose from about 102 to 1011 particles which are biodegradable, substantially non-toxic, initially substantially water-insoluble, and slowly become partially or fully dissolved in the peritoneal cavity or int he lymphatic ducts of said mammal, said particles comprises of at least one material selected from the group consisting of polysaccharides, cellulose and cellulose drivatives, fibrous proteins, plasma proteins, dextran, lactin, polypeptides, polyamino acids, polyesters, polyamides, polyanhydrides, poly(ortho ester), polyacrylates, poly(cyano acrylates), polyvinyl pyrrolidone, phospholipids, polystyrene and polymethylmethacrylate, and said particles have an average particle size in the range from about 15 to 150 microns in their shortest cross section.
Specification