Injectable polymeric bodies

• US 5,158,573 A
• Filed: 03/22/1991
• Issued: 10/27/1992
• Est. Priority Date: 06/09/1989
• Status: Expired due to Term

• Current Assignee: Ams Research Corporation (Endo International PLC)
• Original Assignee: American Medical Systems Incorporated (Endo International PLC)
• Inventors: Berg, Eric P.
• Primary Examiner(s): Isabella, David
• Assistant Examiner(s): BRITTINGHAM, DEBRA
• Application Number:
  US07/675,346
• Time in Patent Office: 585 Days
• Field of Search: 623/66, 623/11, 604/12, 604/890.1, 604/891.1, 604/892.1, 606/86, 606/92, 606/76, 424/423
• US Class Current: 523/113
• CPC Class Codes: A61F 2/0059 Cosmetic or alloplastic implants A61F2/10 - A61F2/16, A61F2/28 take precedence
• CPC Class Codes: A61L 27/16 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids
• CPC Class Codes: C08L 33/20 Homopolymers or copolymers of acrylonitrile C08L55/02 takes precedence
• CPC Class Codes: Y10S 623/926 Synthetic

Abstract

An injectable composition consisting of a plurality of discrete physiologically-compatible, non-biodegradable, silicone rubber bodies, said bodies having (i) a maximum outside dimension of from about 0.005 to 0.08 inch (125 to 2000μ), (ii) reversible deformability of about 20 to 75% of their unstressed outside dimension and (iii) a lubricious surface, wherein the lubricious surface is provided by a thin film coating of a liquid lubricant; and a method for treating a tissue condition in a patient using said composition.

Claims

1. An injectable composition consisting of a plurality of discrete physiologically-compatible, non-biodegradable, silicone rubber bodies, said bodies having (i) a maximum outside dimension of from about 0.005 to 0.08 inch (125 to 2000μ

), (ii) reversible deformability of about 20 to 75% of their unstressed outside dimension, and (iii) a lubricious surface, wherein the lubricious surface is provided by a thin film coating of a liquid lubricant.

2. A composition according to claim 1, in which said silicone rubber bodies have a maximum outside dimension of from about 0.007 to 0.045 inch (175 to 1125μ

).

3. A composition according to claim 2, in which said liquid lubricant is a solution of 25% polyvinyl pyrrolidone having a molecular weight of about 360,000 in phosphate buffered saline.

4. A composition according to claim 1, in which said liquid lubricant is selected from the group consisting of (i) a solution of polyvinyl pyrrolidine in glycerol or phosphate buffered saline;

(ii) a solution of hyaluronic acid in a glycerol/water mixture or phosphate buffered saline; and

(iii) a solution of a water-soluble polysaccharide in glycerol or phosphate buffered saline.

5. A composition according to claim 4, in which said liquid lubricant is a solution of 5% polyvinyl pyrrolidone having a molecular weight of about 360,000 in glycerol.

6. A composition according to claim 4, in which said liquid lubricant is a solution of 0.2% hyaluronic acid having a molecular weight of about 600,000 in 90:

10 glycerol/water.

7. A composition according to claim 4, in which said liquid lubricant is a solution of 2.0% hyaluronic acid in phophate buffered saline.

8. A composition according to claim 4, in which said liquid lubricant is a solution of 10% dextran in glycerol.

9. A composition according to claim 4, in which said liquid lubricant is a solution of 50% dextran in phosphate buffered saline.