Apparatus and method for detecting abnormal cardiac rhythms in dual chamber arrhythmia control system

• US 5,161,527 A
• Filed: 02/13/1991
• Issued: 11/10/1992
• Est. Priority Date: 02/13/1991
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Telectronics Pacing Systems, Inc (Abbott Laboratories Incorporated)
• Inventors: Nappholz, Tibor A., Koestner, Ken
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): MANUEL, GEORGE C
• Application Number:
  US07/654,930
• Time in Patent Office: 636 Days
• Field of Search: 128/419 PG, 128/419 D, 128/419 P
• US Class Current: 607/14
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions

Abstract

A rate-responsive dual-chamber antitachycardia pacer and pacing method which automatically diagnoses and supports a patient'"'"'s hemodynamic status by measuring metabolic demand and sensing intracardiac electrograms to determine whether the heart is beating normally or under conditions of bradycardia, tachycardia, or fibrillation. The pacer supports the patient'"'"'s metabolic demand by electrically stimulating the heart at a pacing rate driven either by the heart'"'"'s sinus node or, alternatively, by the patient'"'"'s metabolic demand (a metabolic demand indicator), as determined by a sensor. The pacer automatically selects between the indicated rates to determine the best pacing rate for appropriately satisfying metabolic demand at all times. The natural rate, driven by the sinus node, takes precedence over the metabolic indicator rate, provided the natural rate meets a standard determined by the metabolic demand indicator rate. The pacer detects abnormal rhythms of tachycardia and fibrillation, classifies these rhythms, and initiates an appropriate therapy accordingly, by analyzing the metabolic demand indicator and the sinus rate.

Claims

1. A dual chamber antitachycardia pacing device for the reversion of tachycardias in a patient'"'"'s heart, comprising:

means for generating atrial and ventricular stimulation pulses,

means for determining the patient'"'"'s intrinsic atrial heartbeat rate,

at least one means for determining the patient'"'"'s metabolic indicator rate,

means for determining the patient'"'"'s maximum atrial tracking rate as a function of said metabolic indicator rate,

means for comparing said intrinsic atrial heartbeat rate to said maximum atrial tracking rate, and

means responsive to said comparing means for controlling said generating means to operate in a first mode in which ventricular pacing pulses are generated in synchrony with said intrinsic atrial heartbeat rate when said intrinsic atrial heartbeat rate is slower than said maximum atrial tracking rate, and for controlling said generating means to operate in a second, antitachycardia pacing, mode when said intrinsic atrial heartbeat rate exceeds said maximum atrial tracking rate.

2. A dual chamber antitachycardia pacing device according to claim 1, wherein said stimulation pulse generating means, when operating in synchrony with said intrinsic atrial heartbeat rate and in the absence of an intrinsic ventricular heartbeat, generates a ventricular pulse after an A-V delay interval following each intrinsic atrial heartbeat, and further including means for adjusting said A-V delay interval as a function of said metabolic indicator rate.

5. A dual chamber antitachycardia pacing device according to claim 2, wherein said at least one means for determining the patient'"'"'s metabolic indicator rate includes a fast-acting sensor means for deriving a rapidly varying metabolic indicator rate and a slower-acting sensor means for deriving a slowly varying, stabilized, metabolic indicator rate, and wherein said metabolic indicator rate is determined to be the faster one of the two metabolic indicator rates derived by said fast-acting sensor means and said slower-acting sensor means.

6. A dual chamber antitachycardia pacing device according to claim 5 wherein said fast-acting sensor means derives intracardia evoked potential amplitude and said slower-acting sensor means derives respiratory minute volume.

3. A dual chamber antitachycardia pacing device for the reversion of tachycardias in a patient'"'"'s heart, comprising:

means for generating atrial and ventricular stimulation pulses,

means for determining the patient'"'"'s intrinsic atrial heartbeat rate,

at least one means for determining the patient'"'"'s metabolic indicator rate,

means for determining the patient'"'"'s maximum atrial tracking rate as a function of said metabolic indicator rate,

means for comparing said intrinsic atrial heartbeat rate to said maximum atrial tracking rate, and

means responsive to said comparing means for controlling said generating means to operate in a first mode in which ventricular pacing pulses are generated in synchrony with said intrinsic atrial heartbeat rate when said intrinsic atrial heartbeat rate is slower than said maximum atrial tracking rate, and for controlling said generating means to operate in a second, antitachycardia pacing, mode when said intrinsic atrial heartbeat rate exceeds said maximum atrial tracking rate,

wherein in said second mode, atrial and ventricular pacing pulses are generated and delivered in a series of pulse trains with each train consisting of a plurality of pacing pulses delivered in an alternating pulse sequence to the ventricle and to the atrium.

4. A dual chamber antitachycardia pacing device according to claim 3, wherein said stimulation pulse generating means, when operating in said second mode, delivers said alternating pulse sequence so that timing of said delivered pulses is in accordance with the value of the A-V interval, whereby each train comprises the delivery of a pacing pulse to the atrium at the expiration of each V-A delay interval and a pacing pulse to the ventricle at the expiration of each A-V delay interval, and means for varying said A-V delay interval from an initial value, which is determined as a function of said metabolic indicator rate, and is adjusted at least once prior to completion of each of said series of pulse trains.

7. A dual chamber antitachycardia pacing device for the reversion of tachycardias in a patient'"'"'s heart, comprising:

means for generating atrial and ventricular stimulation pulses,

means for determining the patient'"'"'s intrinsic atrial heartbeat rate,

at least one means for determining the patient'"'"'s metabolic indicator rate,

means for comparing said metabolic indicator rate with said intrinsic atrial heartbeat rate and, depending on the results of the comparison, classifying said intrinsic atrial heartbeat rate as either physiological or pathological; and

control means operative when the atrial heartbeat rate is physiological for controlling said stimulation pulse generating means to operate in response to said intrinsic atrial heartbeat rate, and operative when the atrial heartbeat rate is pathological for controlling said stimulation pulse generating means to operate in an antitachycardia pacing mode.

8. A dual chamber antitachycardia pacing device according to claim 7, wherein said stimulation pulse generating means, when operating in synchrony with said intrinsic atrial heartbeat rate and in the absence of an intrinsic ventricular heartbeat, generates a ventricular pulse after an A-V delay interval following each intrinsic atrial heartbeat, and further including means for adjusting said A-V delay interval as a function of said metabolic indicator rate.

9. A dual chamber antitachycardia pacing device for the reversion of tachycardias in a patient'"'"'s heart, comprising:

means for generating atrial and ventricular stimulation pulses,

means for determining the patient'"'"'s intrinsic atrial heartbeat rate,

at least one means for determining the patient'"'"'s metabolic indicator rate,

means for comparing said metabolic indicator rate with said intrinsic atrial heartbeat rate and, depending on the result of the comparison, classifying said intrinsic atrial heartbeat rate as either physiological or pathological; and

control means operative when the atrial heartbeat rate is physiological for controlling said stimulation pulse generating means to operate in response to said intrinsic atrial heartbeat rate, and operative when the atrial heartbeat rate is pathological for controlling said stimulation pulse generating means to operate in an antitachycardia pacing mode,

wherein in said antitachycardia pacing mode, atrial and ventricular pacing pulses are generated and delivered in a series of pulse trains with each train consisting of a plurality of pacing pulses delivered in an alternating pulse sequence to the ventricle and to the atrium.

10. A dual chamber antitachycardia pacing device according to claim 9 wherein said stimulation pulse generating means, when operating in said antitachycardia pacing mode, delivers said alternating pulse sequence so that timing of said delivered pulses is in accordance with the value of the A-V interval, whereby each train comprises the delivery of a pacing pulse to the atrium at the expiration of each V-A delay interval and a pacing pulse to the ventricle at the expiration of each A-V delay interval, and means for varying said A-V delay interval from an initial value, which is determined as a function of said metabolic indicator rate and is adjusted at least once prior to completion of each of said series of pulse trains.

11. A dual chamber antitachycardia pacing device according to claim 9 wherein said at least one means for determining the patient'"'"'s metabolic indicator rate includes a fast-acting sensor means for deriving a rapidly varying metabolic indicator rate and a slower-acting sensor means for deriving a slowly varying, stabilized, metabolic indicator rate, and wherein said metabolic indicator rate is determined to be the faster one of the two metabolic indicator rates derived by said fast-acting sensor means and said slower-acting sensor means.

12. A dual chamber antitachycardia pacing device according to claim 11 wherein said fast-acting sensor means derives intracardiac evoked potential amplitude and said slower-acting sensor means derives respiratory minute volume.

13. A dual chamber antitachycardia pacing device for the reversion of tachycardias in a patient'"'"'s heart, comprising:

means for generating atrial and ventricular pacing pulses;

means for sensing atrial and ventricular heartbeats;

at least one means for determining a metabolic indicator rate;

means for ascertaining whether sensed atrial heartbeats are occurring at a rate which is pathological for said metabolic indicator rate; and

means for controlling said generating and sensing means to operate normally in a DDDR mode but to switch to an antitachycardia pacing mode when the rate of the atrial heartbeats is pathological.

14. A dual chamber antitachycardia pacing device according to claim 13, wherein said pacing pulse generating means, when operating in synchrony with intrinsic atrial heartbeats and in the absence of intrinsic ventricular heartbeats, generates a ventricular pulse after an A-V delay interval following each intrinsic atrial heartbeat, and further including means for adjusting said A-V delay interval as a function of said metabolic indicator rate.

15. A dual chamber antitachycardia pacing device according to claim 13, wherein said at least one means for determining a metabolic indicator rate includes a fast-acting sensor means for deriving a rapidly varying metabolic indicator rate and a slower-acting sensor means for deriving a slowly varying, stabilized, metabolic indicator rate, and wherein said metabolic indicator rate is determined to be the faster one of the two metabolic indicator rates derived by said fast-acting sensor means and said slower-acting sensor means.

16. A dual chamber antitachycardia pacing device according to claim 15, wherein said fast-acting sensor means derives intracardiac evoked potential amplitude and said slower-acting sensor means derives respiratory minute volume.

17. A dual chamber antitachycardia pacing device for the reversion of tachycardias in a patient'"'"'s heart, comprising:

means for generating atrial and ventricular pacing pulses;

means for sensing atrial and ventricular heartbeats;

at least one means for determining a metabolic indicator rate;

means for ascertaining whether sensed atrial heartbeats are occurring at a rate which is pathological for said metabolic indicator rate; and

means for controlling said generating and sensing means to operate normally in a DDDR mode but to switch to an antitachycardia pacing mode when the rate of the atrial heartbeats is pathological,

wherein in said antitachycardia pacing mode, atrial and ventricular pacing pulses are generated and delivered in a series of pulse trains with each train consisting of a plurality of pacing pulses delivered in an alternating pulse sequence to the ventricle and to the atrium.

18. A dual chamber antitachycardia pacing device according to claim 17, wherein said pacing pulse generating means, when operating in said antitachycardia pacing mode, delivers said alternating pulse sequence so that timing of said delivered pulses is in accordance with the value of the A-V interval, whereby each train comprises the delivery of a pacing pulse to the atrium at the expiration of each V-A delay interval and a pacing pulse to the ventricle at the expiration of each A-V delay interval, and means for varying said A-V delay interval from an initial value, which is determined as a function of said metabolic indicator rate and is adjusted at least once prior to completion of each of said series of pulse trains.

19. A method of utilizing a dual chamber antitachycardia pacing device to revert tachycardias in a patient'"'"'s heart, comprising the steps of:

determining the patient'"'"'s intrinsic atrial heartbeat rate,

determining the patient'"'"'s metabolic indicator rate,

determining a maximum atrial tracking rate as a function of said metabolic indicator rate,

comparing said intrinsic atrial heartbeat rate to said maximum atrial tracking rate, and

in response to said comparing step, generating ventricular pacing pulses in synchrony with said atrial heartbeat rate when said intrinsic atrial heartbeat rate is slower than said maximum atrial tracking rate and generating pacing pulses in an antitachycardia therapy mode when said intrinsic atrial heartbeat rate exceeds said maximum atrial tracking rate.

20. A method according to claim 19, wherein during said step of generating ventricular pacing pulses, when ventricular pacing pulses are being generated in synchrony with said intrinsic atrial heartbeat rate, each of said ventricular pulses is generated after an A-V delay interval which follows an atrial heartbeat, said method further including the step of adjusting said A-V delay interval as a function of said metabolic indicator rate.

22. A method according to claim 20, wherein said step of determining the patient'"'"'s metabolic indicator rate includes the sub-steps of:

deriving a first, rapidly varying, metabolic indicator rate,

deriving a second, slowly varying, stable metabolic indicator rate, and

determining the metabolic indicator rate to be the faster one of said first and second metabolic indicator rates.

23. A method according to claim 22, wherein said first metabolic indicator rate comprises a function of the patient'"'"'s intracardiac evoked potential amplitude and said second metabolic indicator rate comprises a function of the patient'"'"'s respiratory minute volume.

21. A method of utilizing a dual chamber antitachycardia pacing device to revert tachycardias in a patient'"'"'s heart, comprising the steps of:

determining the patient'"'"'s intrinsic atrial heartbeat rate,

determining the patient'"'"'s metabolic indicator rate,

determining a maximum atrial tracking rate as a function of said metabolic indicator rate,

comparing said intrinsic atrial heartbeat rate to said maximum atrial tracking rate, and

in response to said comparing step, generating ventricular pacing pulses in synchrony with said atrial heartbeat rate when said intrinsic atrial heartbeat rate is slower than said maximum atrial tracking rate and generating pacing pulses in an antitachycardia therapy mode when said intrinsic atrial heartbeat rate exceeds said maximum atrial tracking rate,

wherein said antitachycardia therapy mode includes the sub-steps of;

delivering a pulse to the ventricle,

determining a V-A delay interval as a function of said metabolic indicator rate,

delivering a pulse to the atrium at the expiration of said determined V-A interval in the absence of an intrinsic atrial heartbeat during said V-A interval,

determining an A-V delay interval as a function of said metabolic indicator rate,

delivering a pulse to the ventricle at the expiration of said A-V interval in the absence of an intrinsic ventricular heartbeat during said A-V interval,

repeating the aforesaid pulse deliveries to the atrium and the ventricle for a plurality of intervals defining a pulse train, and

varying said A-V delay interval value from the initial value at least once prior to the completion of a series of trains of pulses.

24. A method of utilizing a dual chamber antitachycardia pacing device to revert tachycardias in a patient'"'"'s heart, comprising the steps of

generating atrial and ventricular pacing pulses;

sensing the patient'"'"'s atrial and ventricular heartbeats and determining the patient'"'"'s atrial and ventricular heartbeat rates;

determining the patient'"'"'s metabolic indicator rate;

ascertaining whether sensed atrial heartbeats are occurring at a rate which is pathological for said metabolic indicator rate; and

performing said generating and sensing steps in a DDDR mode when said atrial heartbeat rate is non-pathological, and in an antitachycardia pacing mode when said atrial heartbeat rate is pathological.

25. A method according to claim 24, wherein during said step of generating ventricular pacing pulses, when ventricular pacing pulses are being generated in synchrony with said intrinsic atrial heartbeat rate, each of said ventricular pulses is generated after an A-V delay interval which follows an atrial heartbeat, said method further including the step of adjusting said A-V delay interval as a function of said metabolic indicator rate.

26. A method of utilizing a dual chamber antitachycardia pacing device to revert tachycardias in a patient'"'"'s heart, comprising the steps of:

generating atrial and ventricular pacing pulses;

sensing the patient'"'"'s atrial and ventricular heartbeats and determining the patient'"'"'s atrial and ventricular heartbeat rates;

determining the patient'"'"'s metabolic indicator rate;

ascertaining whether sensed atrial heartbeats are occurring at a rate which is pathological for said metabolic indicator ate; and

performing said generating and sensing steps in a DDDR mode when said atrial heartbeat rate is non-pathological, and in an antitachycardia pacing mode when said atrial heartbeat rate is pathological,

wherein said antitachycardia therapy mode includes the substeps of;

delivering a pulse to the ventricle,

determining a V-A delay interval as a function of said metabolic indicator rate,

delivering a pulse to the atrium at the expiration of said determined V-A interval in the absence of an intrinsic atrial heartbeat during said V-A interval,

determining an A-V delay interval as a function of said metabolic indicator rate,

delivering a pulse to the ventricle at the expiration of said A-V interval in the absence of an intrinsic ventricular heartbeat during said A-V interval,

repeating the aforesaid pulse deliveries to the atrium and the ventricle for a plurality of intervals defining a pulse train, and

varying said A-V delay interval value from the initial value at least once prior to the completion of a series of trains of pulses.

27. A method according to claim 26, wherein said step of determining the patient'"'"'s metabolic indicator rate includes the sub-steps of:

deriving a first, rapidly varying metabolic indicator rate,

deriving a second, slowly varying, stable, metabolic indicator rate, and

determining the metabolic indicator rate to be the faster one of said first and second metabolic indicator rates.

28. A method according to claim 27, wherein said first metabolic indicator rate comprises a function of the patient'"'"'s intracardiac evoked potential amplitude and said second metabolic indicator rate comprises a function of the patient'"'"'s respiratory minute volume.