Iontophoretic delivery device

• US 5,162,043 A
• Filed: 11/06/1991
• Issued: 11/10/1992
• Est. Priority Date: 03/30/1990
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Gyory, J. Richard, Lew, Patrick J.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): ZELE, KRISTA MICHELLE
• Application Number:
  US07/788,661
• Time in Patent Office: 370 Days
• Field of Search: 604/20, 128/639-641, 128/798, 128/802, 128/803
• US Class Current: 604/20
• CPC Class Codes: A61N 1/0436 Material of the electrode
• CPC Class Codes: A61N 1/0448 Drug reservoir

Abstract

An iontophoretic agent delivery device having donor and counter electrodes comprised of either metal or a hydrophobic polymer loaded with a conductive filler is provided. The agent reservoir in the donor electrode assembly contains about 10 to 60 wt % hydrophobic polymer, about 10 to 60 wt % hydrophilic polymer, and up to 50% agent. Similarly, the electrolyte reservoir contains about 10 to 60 wt % hydrophobic polymer, about 10 to 60 wt % hydrophilic polymer, and up to 50% electrolyte. The agent reservoir, the electrolyte reservoir and the electrodes are preferably in the form of films which are laminated to one another. The hydrophobic polymer component in the agent/electrolyte reservoir prevents the reservoir from delaminating from the metal/hydrophobic polymer based electrode, even after hydration of the reservoirs.

Claims

1. An electrically powered iontophoretic agent delivery device including a donor electrode assembly, a counter electrode assembly and a source of electrical power electrically connected to the donor electrode assembly and the counter electrode assembly, the donor electrode assembly comprising:

a) an agent reservoir containing an agent, the agent reservoir adapted to be placed in agent transmitting relation with a body surface; and

b) a donor electrode electrically connected to the source of electrical power, the donor electrode also being in electrical contact with the agent reservoir;

wherein the agent reservoir is comprised of about 10 to 60 wt % of a polyvinylpyrrolidone, about 10 to 60 wt % of a solid heat fusible polyisobutylene and up to about 60 wt % of the agent.

2. The device of claim 1, wherein the donor electrode is comprised of a metal.

3. The device of claim 2, wherein the metal is selected from the group consisting of silver and zinc.

4. The device of claim 1, wherein the donor electrode comprises a hydrophobic polymer matrix containing a conductive filler.

5. The device of claim 4, wherein the conductive filler comprises metal particles.

6. The device of claim 4, wherein the conductive filler comprises carbon fibers.

7. The device of claim 4, wherein the agent reservoir and the donor electrode are each in the form of a film.

8. The device of claim 7, wherein the donor electrode and the agent reservoir are laminated to one another.

9. The device of claim 7, wherein the films are adhered to one other with an ionically conductive adhesive.

10. The device of claim 1, wherein the counter electrode assembly includes a counter electrode electrically connected to the source of electrical power and an electrolyte reservoir adapted to be placed in electrolyte transmitting relation with the body surface, the counter electrode also being in electrical contact with the electrolyte reservoir;

wherein the electrolyte reservoir is comprised of about 10 to 60 wt % of a polyvinylpyrrolidone, about 10 to 60 wt % of a solid heat fusible polyisobutylene and up to about 50 wt % of the electrolyte.

11. The device of claim 10, wherein the counter electrode is comprised of a metal.

12. The device of claim 11, wherein the metal is selected from the group consisting of silver and zinc.

13. The device of claim 10, wherein the counter electrode is comprised of a hydrophobic polymer containing a conductive filler.

14. The device of claim 13, wherein the conductive filler comprises metal particles.

15. The device of claim 13, wherein the conductive filler comprises carbon fibers.

16. The device of claim 13, wherein the counter electrode and the electrolyte reservoir are each in the form of a film.

17. The device of claim 16, wherein the counter electrode and the electrolyte reservoir are laminated to one another.

18. The device of claim 16, wherein the films are adhered to one another with an ionically conductive adhesive.

19. The device of claim 10, wherein the electrolyte reservoir also comprises a tackifying resin.

20. The device of claim 19, wherein the tackifying resin comprises a low molecular weight polyisobutylene.

21. The device of claim 10, wherein the electrolyte reservoir comprises about 20 to 40 wt % polyvinylpyrrolidone.

22. The device of claim 10, wherein the electrolyte reservoir comprises about 30 to 50 wt % polyisobutylene.

23. The device of claim 10, wherein the electrolyte reservoir comprises about 25 to 50 wt % of the electrolyte.

24. The device of claim 10, wherein the electrolyte reservoir also contains a polyethylene glycol.

25. The device of claim 10, wherein the polyvinylpyrrolidone is crosslinked.

26. The device of claim 1, wherein the agent reservoir also comprises a tackifying resin.

27. The device of claim 26, wherein the tackifying resin comprises a low molecular weight polyisobutylene.

28. The device of claim 1, wherein the agent reservoir comprises about 20 to 40 wt % polyvinylpyrrolidone.

29. The device of claim 1, wherein the agent reservoir comprises about 30 to 50 wt % polyisobutylene.

30. The device of claim 1, wherein the agent reservoir comprises about 25 to 50 wt % of the agent.

31. The device of claim 1, wherein the agent reservoir also contains a polyethylene glycol.

32. The device of claim 1, wherein the polyvinylpyrrolidone is crosslinked.