Hemodynamically responsive system for treating a malfunctioning heart

• US 5,163,429 A
• Filed: 06/28/1991
• Issued: 11/17/1992
• Est. Priority Date: 10/06/1987
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Leonard Bloom
• Inventors: Cohen, Todd J.
• Primary Examiner(s): Jaworski, Francis
• Assistant Examiner(s): MANUEL, GEORGE C
• Application Number:
  US07/723,298
• Time in Patent Office: 508 Days
• Field of Search: 128/419 PG, 128/419 D
• US Class Current: 607/4
• CPC Class Codes: A61N 1/36564 controlled by blood pressure
• CPC Class Codes: A61N 1/3918 characterised by shock pathway, e.g. by electrode configuration
• CPC Class Codes: A61N 1/39622 Pacing therapy

Abstract

A system for treating a malfunctioning heart is based on hemodynamics, the pressure at a site in a patient'"'"'s circulatory system being sensed. A signal is developed representative of short term mean arterial pressure (MAP), mean right atrial pressure (MRAP), mean right ventricle pressure (MRVP), mean left atrial pressure (MLAP), mean left ventricle pressure (MLVP), mean central venous pressure (MCVP), mean pulmonary artery pressure (MPAP), mean pulmonary vein pressure (MPVP), mean pulmonary capillary wedge pressure (MPCWP), right ventricular systolic pressure (RVSP), right ventricular end diastolic pressure (RVEDP), or right ventricular pulse pressure (RVPP). A signal representative of fixed or varying baseline pressure is provided and if the short term current pressure differs therefrom by a predetermined value, an indication of hemodynamic compromise, cardioversion/defibrillation is effected. In a second embodiment, the determination of whether the difference between fixed or varying baseline pressure and current pressure is undertaken after a rate criteria (for example a heart rate above 155 b.p.m.) has been met. In a third embodiment, the rate and pressure criteria both must exist at the same time, before cardioverting/-defibrillation is initiated. In a fourth embodiment, a microprocessor is used. The system includes antitachycardia and antibradycardia pacemakers.

Claims

1. A system for treating a malfunctioning heart comprising first means for deriving at least one electrical signal representing electrical activity of the heart;

second means for deriving at least one signal representing at least one hemodynamic parameter;

signal processing means responsive to outputs from said first means and said second means for developing at least three control signals and a signal representative of occurrences of an R-wave;

controllable antitachycardia pacemaking means for supplying pacing signals to the heart;

controllable antibradycardia pacemaking means for supplying pacing signals to the heart; and

controllable cardioverting/defibrillating means, said cardioverting/defibrillating means, said antibradycardia pacemaking means and said antitachycardia pacemaking means being coupled to said signal processing means and responsive to the control signals therefrom for selectively treating heart rhythm malfunctions.

2. The system according to claim 1, including means for developing a discharge-synchronizing signal synchronized to the R-wave, and wherein said cardioverting/defibrillator means includes means for synchronizing application of electrical energy pulses to the heart with the discharge-synchronizing signal to effect cardioversion.

3. The system according to claim 2, wherein said cardioverting/defibrillating means includes means to effect application of electrical energy pulses to the heart on a nonsynchronized basis, in the absence of the synchronization signal, to effect defibrillation.

4. The system according to claim 1, wherein said cardioverting/defibrillating means includes means for applying electrical energy pulses to the heart on a nonsynchronized basis.

5. The system according to claim 1, wherein said signal processing means comprises a microprocessor.

6. The system according to claim 1, including means for developing a varying baseline for the at least one hemodynamic parameter.

7. The system according to claim 1, including means for developing a fixed baseline for the at least one hemodynamic parameter.

8. The system according to claim 7, including means for adjustably setting the fixed baseline.

9. An implantable system for treating a malfunctioning heart which includes an implantable, controllable cardioverter/defibrillator, first means for deriving at least one electrical signal representing electrical activity of the heart;

second means for deriving at least one signal representing at least one hemodynamic parameter;

signal processing means responsive to outputs from said first means and said second means for developing at least three control signals and a signal representative of occurrences of an R-wave;

controllable antitachycardia pacemaking means for supplying pacing signals to the heart; and

controllable antibradycardia pacemaking means for supply pacing signals to the heart, said implantable cardioverter/defibrillator, said antibradycardia pacemaking means and said antitachycardia pacemaking means being coupled to said signal processing means and responsive to the control signals therefrom for selectively treating heart rhythm malfunctions.

10. The system according to claim 9, including means for developing a discharge-synchronizing signal synchronized to the R-wave, and wherein said cardioverter/defibrillator includes means for synchronizing application of electrical energy pulses to the heart with the discharge-synchronizing signal to effect cardioversion.

11. The system according to claim 10, wherein said cardioverter/defibrillator includes means to effect application of electrical energy pulses to the heart on a nonsynchronized basis, in the absence of the synchronization signal, to effect defibrillation.

12. The system according to claim 9, wherein said cardioverter/defibrillator includes means for applying electrical energy pulses to the heart on a nonsynchronized basis.

13. The system according to claim 9, wherein said signal processing means comprises a microprocessor.

14. The system according to claim 9, including means for developing a varying baseline for the at least one hemodynamic parameter.

15. The system according to claim 9, including means for developing a fixed baseline for the at least one hemodynamic parameter.

16. The system according to claim 15, including means for adjustably setting the fixed baseline.

17. A system for treating a malfunctioning heart, the system comprising a cardioverter/defibrillator, first means for deriving from at least one electrocardiographic signal resulting from electrical activity of the heart at least one signal representing at least an approximation of the probability density function of the electrocardiographic signal;

second means for deriving at least one signal representing at least one hemodynamic parameter; and

signal processing means for developing at least one control signal, said cardioverter/defibrillator being coupled to said signal processing means and responsive to output therefrom.

18. The system according to claim 17, including means for developing a discharge-synchronizing signal synchronized to an R-wave, and wherein said cardioverter/defibrillator includes means for synchronizing application of electrical energy pulses to the heart with the discharge-synchronizing signal whereby cardioversion may be effected.

19. The system according to claim 18, wherein said cardioverter/defibrillator includes means to effect application of electrical energy pulses to the heart on a nonsynchronized basis, in the absence of the synchronization signal whereby defibrillation may be effected.

20. The system according to claim 17, wherein said cardioverter/defibrillator includes means for applying electrical energy pulses to the heart on a nonsynchronized basis.

21. The system according to claim 17, wherein said signal processing means comprises a microprocessor.

22. The system according to claim 17, including means for developing a varying baseline for the at least one hemodynamic parameter.

23. The system according to claim 17, including means for developing a fixed baseline for the at least one hemodynamic parameter.

24. The system according to claim 23, including means for adjustably setting the fixed baseline.

25. The system according to claim 17, wherein said signal processing means responsive to outputs from said first means and said second means for developing control signals;

the system further including controllable antitachycardia pacemaking means for supplying pacing signals to the heart and controllable antibradycardia pacemaking means for supply pacing signal to the heart, said cardioverter/defibrillator, said antibradycardia pacemaking means and said antitachycardia pacemaking means being coupled to said signal processing means and responsive to respective output signals therefrom.

26. The system according to claim 17, further comprising additional means for deriving a heat-rate signal, and wherein said signal processing means is responsive to the heart-rate signal and to the outputs from the first means and the second means.

27. The system according to claim 17, wherein said at least one hemodynamic parameter comprises a pressure parameter.

28. The system according to claim 17, wherein said system is implantable.