Biodegradable ocular implants

• US 5,164,188 A
• Filed: 11/22/1989
• Issued: 11/17/1992
• Est. Priority Date: 11/22/1989
• Status: Expired due to Term

• Current Assignee: Allergan Incorporated (Abbvie Incorporated)
• Original Assignee: Visionex Inc.
• Inventors: Wong, Vernon G.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): AZPURU, CARLOS A
• Application Number:
  US07/440,344
• Time in Patent Office: 1,091 Days
• Field of Search: 424/422, 424/423, 424/427, 424/428, 424/484, 424/486, 514/912, 514/914, 623/4
• US Class Current: 424/428
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Encapsulated agents are employed for introduction into the suprachoroid of an eye for therapeutic purposes. The administration of drugs is controlled and maintained for long periods of time, while ensuring the substantial absence of significant levels outside the site of administration.

Claims

1. A method for treating an eye condition which comprises:

introducing into the suprachoroidal space an eye implant incapable of migration from the suprachoroid, said implant comprises from about 1 to about 80 weight % of an active agent selected from at least one of drugs, pharmaceutical agents, and bacterial agents in a pharmacologically acceptable biodegrable polymer which is degraded in the eye, wherein said implant provides an effective dosage of said drug over an extended period of time.

2. A method according to claim 1, wherein said implant in a plaque.

3. A method according to claim 2, wherein said plaque has length and width dimensions of about 0.5 to 10 mm×

0.5 to 10 mm with a thickness of about 0.25 to 1. mm.

4. A method according to claim 1, wherein said bacterial agent is selected from acid-fast bacilli or C. parvum.

5. A method according to claim 1, wherein said polymer is a condensation polymer.

6. A method according to claim 5, wherein said polymer is a polyester.

7. A method according to claim 6, wherein said polyester comprises an hydroxyaliphatic carboxylic acid monomer.