Capillary flow device
First Claim
1. A system for detecting the presence of an analyte in or a property of blood, comprising:
- a housing containing a capillary passageway capable of independently pumping blood into said passageway as the sole motive source in said passageway;
a reagent contained within said passageway capable of causing said blood to clot to provide a detectable signal in relationship to said analyte or property; and
a monitor comprising means for holding said housing, means for passing light through said capillary passageway, means for detecting scattering of light that passes through said passageway, and means for analyzing scattered light to determine when clotting occurs in said passageway.
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Accused Products
Abstract
Novel methods and devices are provided involving at least one chamber, at least one capillary, and at least one reagent involved in a system providing for a detectable signal. As appropriate, the devices provide for measuring a sample, mixing the sample with reagents, defining a flow path, and reading the result. Of particular interest is the use of combinations of specific binding pair members which result in agglutination information, where the resulting agglutination particles may provide for changes in flow rate, light patterns of a flowing medium, or light absorption or scattering. A fabrication technique particularly suited for forming internal chambers in plastic devices is also described along with various control devices for use with the basic device.
362 Citations
2 Claims
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1. A system for detecting the presence of an analyte in or a property of blood, comprising:
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a housing containing a capillary passageway capable of independently pumping blood into said passageway as the sole motive source in said passageway; a reagent contained within said passageway capable of causing said blood to clot to provide a detectable signal in relationship to said analyte or property; and a monitor comprising means for holding said housing, means for passing light through said capillary passageway, means for detecting scattering of light that passes through said passageway, and means for analyzing scattered light to determine when clotting occurs in said passageway.
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2. A device for use in a system for detecting the presence of an analyte in a blood sample, comprising:
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a substantially hydrophobic housing having at least a portion of the walls treated to provide hydrophilicity, said housing comprising a capillary passageway having hydrophilic walls and being capable of pumping blood as the sole motive source in said device; and a reagent in said passageway, wherein said reagent causes blood to clot and is a member of a system capable of providing a detectable signal in relation to the presence of said analyte or property.
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Specification