Gene therapy using gene fusions for genetic or acquired disorders
First Claim
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1. A nucleotide sequence encoding an MDR1-ADA fusion gene comprising the coding sequence for the human MDR1 gene directly linked to the 5'"'"' end of the coding sequence for the ADA gene, wherein the linked coding sequences form a single open reading frame.
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Abstract
Gene therapy utilizing an MDR1 linked fusion coding sequence has been disclosed. ADA activity has been introduced into cells using MDR1 linked fusion gene.
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8 Claims
- 1. A nucleotide sequence encoding an MDR1-ADA fusion gene comprising the coding sequence for the human MDR1 gene directly linked to the 5'"'"' end of the coding sequence for the ADA gene, wherein the linked coding sequences form a single open reading frame.
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3. An expression vector having the identifying characteristics of ATCC 67699.
Specification