Miniaturized sensor for ionizing radiation

• US 5,166,073 A
• Filed: 05/05/1989
• Issued: 11/24/1992
• Est. Priority Date: 05/05/1989
• Status: Expired due to Fees

• Current Assignee: The Dow Chemical Company (Dow, Inc.)
• Original Assignee: The Dow Chemical Company (Dow, Inc.)
• Inventors: Lefkowitz, Steven M., Chrisman, Ray, Helmer, Deborah C., Brownell, Steven J., Kastl, Patrick E., Leugers, Mary A., Langvardt, Patrick W.
• Primary Examiner(s): Warden, Robert J.
• Assistant Examiner(s): ALEXANDER, LYLE
• Application Number:
  US07/347,692
• Time in Patent Office: 1,299 Days
• Field of Search: 422/58, 422/68.1, 422/82.05, 422/82.06, 422/82.09, 422/82.11, 436/57, 436/164, 128/633, 128/634, 128/659, 128/661.08, 128/662.06, 128/663.01, 250/483.1, 250/484.1, 250/485.1, 250/487.1, 356/73.1, 356/402, 356/412
• US Class Current: 436/57
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: G01T 1/161 Applications in the field of nuclear medicine, e.g. in vivo counting apparatus for radiation diagnosis A61B6/00
• CPC Class Codes: G01T 1/20 with scintillation detectors

Abstract

The invention is an optical sensor useful for the detection of ionizing radiation emitted from an analyte in a fluid. The sensor is composed of a permeable scintillator having a high surface area to scintillator volume ratio and an optical waveguide located in working relation to the scintillator to collect light photons generated in response to an ionizing radiation source. The sensor is especially useful for biomedical applications. Increased sensitivity allows for miniaturization and implantation in a blood vessel of a small experimental animal.

Claims

1. A sensor for determining the concentration of an ionizing radiation emitting analyte in a fluid comprising:

(a) a scintillator having permeability to said fluid, said scintillator being effective for yielding a sensitivity to ionizing radiation above 2.5×

10³ counts per minute per disintegration per minute per microliter per cubic meter of scintillator (cpm/dpm/μ

l/m3); and

(b) an optical waveguide in working relation with said scintillator to collect light photons generated by said scintillator in response to an ionizing radiation source.

2. The sensor of claim 1 wherein the sensor includes a permeable membrane surrounding the scintillator.

3. The sensor of claim 1 wherein the sensor includes a reflecting surface positioned with respect to the optical waveguide and the scintillator in a manner such that the intensity of light photons impinging on the waveguide is substantially increased.

4. The sensor of claim 1 wherein the scintillator is sensitive to beta emitting ionizing radiation.

5. The sensor of claim 1 wherein the sensor has a diameter of from about 50 to about 1000 micrometers.

6. The sensor of claim 1 wherein the sensor has a diameter of from about 400 to about 600 micrometers.

7. The sensor of claim 1 wherein the sensor includes a semipermeable membrane surrounding the scintillator.

8. The sensor of claim 7 wherein the semipermeable membrane is selected from the group consisting of cellulose acetate, polyvinylidene fluoride, polytetrafluoroethylene, copolymers of acrylonitrile/vinylpyrrolidone, polyamideimide, polysulfone, polyamide, hydrophilic polyolefin, copolymer of acrylonitrile/methallyl sulfonate, sulfonated polysulfone, silicone rubber, microporous polyolefin, polytetrafluoroethylene and combinations thereof.

9. The sensor of claim 8 wherein the semipermeable membrane is selected from the group consisting of cellulose acetate, polysulfone, sulfonated polysulfone, polyfluorocarbon and combinations thereof.

10. The sensor of claim 1 wherein the optical waveguide is an optical fiber.

11. The sensor of claim 10 wherein the scintillator is selected from the group consisting of organic crystal, organic plastic, inorganic crystal, inorganic amorphous solid and combinations thereof.

12. The sensor of claim 11 wherein the scintillator is selected from the group consisting of anthracene, picene, naphthacene, naphthalene, pentacene, hexacene, phenanthrene, fluoranthene, chrysens, pyrene, fluorene, carbazole, diphenylene oxide and combinations thereof.

13. The sensor of claim 1 wherein the scintillator is an openly cellular foam.

14. The sensor of claim 13 wherein the foam is a polymeric matrix in combination with at least one scintillator.

15. The sensor of claim 14 wherein the polymeric matrix is selected from the group consisting of poly(styrene), poly(vinyl toluene), poly(vinyl naphthalene), poly(vinyl anthracene), poly(methyl methacrylate) and the copolymers and blends thereof.

16. A method for determining the concentration of an ionizing radiation emitting analyte in a fluid medium, comprising the steps of:

(A)inserting a sensor into the medium, wherein the sensor comprises;

(a) a scintillator having a permeability to said fluid; and

(b) an optical waveguide in working relation with said scintillator to collect light photons generated by said scintillator in response to an ionizing radiation source;

(B) collecting the light photons from the scintillator through the waveguide;

(C) measuring the number of the light photons and relating the measured number to a known standard to determine the concentration of the analyte in the fluid medium.

17. The method of claim 16 wherein the sensor further comprises a reflecting surface positioned with respect to the optical waveguide and the scintillator in a manner such that the intensity of light photons impinging on the waveguide is substantially increased.

18. The method of claim 16 wherein the optical waveguide is an optical fiber.

19. The method of claim 16 wherein the scintillator is selected from the group consisting of organic crystal, organic plastic, inorganic crystal, inorganic solid and composites thereof.

20. The method of claim 19 wherein the scintillator is selected from the group consisting of anthracene, picene, naphthacene, naphthalene, pentacene, hexacene, phenanthrene, fluoranthene, chrysene, pyrene, fluorene, carbazole, diphenylene oxide and combinations thereof.

21. The method of claim 16 wherein the scintillator is selected from the group consisting of anthracene, phenanthrene, fluoranthene, naphthacene, fluorene and carbazole.

22. The method of claim 16 wherein the analyte comprises a beta emitting compound.

23. The method of claim 16 wherein the analyte comprises a compound labelled with ¹⁴ C.

24. The method of claim 16 wherein the sensor has a diameter of from about 50 to about 1000 micrometers.

25. The method of claim 16 wherein the sensor has a diameter of from about 400 to about 600 micrometers.

26. The method of claim 16 wherein the scintillator is in the form of an openly cellular foam.

27. The method of claim 26 wherein the foam comprises a polymeric matrix in combination with at least one scintillator wherein the polymeric matrix is selected from the group consisting of poly(styrene), poly(vinyl toluene), poly(vinyl naphthalene), poly(vinyl anthracene), poly(methyl methacrylate) and the copolymers and blends thereof.

28. The method of claim 16 wherein the sensor further comprises a semipermeable membrane enclosing the scintillator.

29. The method of claim 28 wherein the semipermeable membrane is selected from the group consisting of cellulose acetate, polyvinylidene fluoride, polytetrafluoroethylene, copolymers of acrylonitrile/vinylpyrrolidone, polyamideimide, polysulfone, polyamide, hydrophilic polyolefin, copolymer of acrylonitrile/methallyl sulfonate, sulfonated polysulfone, silicone rubber, microporous polyolefin, tetrafluoroethylene fluorocarbon and combinations thereof.

30. The method of claim 29 wherein the semipermeable membrane is selected from the group consisting of cellulose acetate, polysulfone, sulfonated polysulfone, polyfluorocarbon and combinations thereof.