Method for determining whether respiratory gas is present in a gaseous sample

• US 5,166,075 A
• Filed: 04/24/1992
• Issued: 11/24/1992
• Est. Priority Date: 08/13/1986
• Status: Expired due to Term

• Current Assignee: Nellcor Puritan Bennett Incorporated (Medtronic Plc)
• Original Assignee: Nellcor Incorporated (Medtronic Plc)
• Inventors: Fehder, Carl G.
• Primary Examiner(s): Johnston, Jill A.
• Application Number:
  US07/873,971
• Time in Patent Office: 214 Days
• Field of Search: 422/56-58, 422/87, 436/133, 436/163, 436/166, 436/167, 436/169, 128/719
• US Class Current: 436/133
• CPC Class Codes: A61M 2016/0413 with detectors of CO2 in exhaled gases
• CPC Class Codes: G01N 31/223 for investigating presence of specific gases or aerosols G01N31/221, G01N31/222 take precedence; actuation of fire alarm by presence of smoke or gases G08B17/10
• CPC Class Codes: Y10T 436/204998 Inorganic carbon compounds

Abstract

A method is disclosed for determining whether respiratory gas is present in a gaseous sample by which the sample is brought into contact with an indicator which yields an indication within a diagnostically effective period of time of the presence in the sample of carbon dioxide in concentration of at least 2% while an indication of the presence of carbon dioxide in a sample of ambient air would be delayed beyond a predetermined period of time. The method has particular utility in determining the correct placement of an endotracheal catheter in a patient or in the detection of apnea.

Claims

1. A method for determining whether a gaseous sample contains a predetermined concentration of carbon dioxide, comprising the step of:

contacting the gaseous sample with a dry reagent detector comprising a carrier having an aqueous indicating composition applied thereto for providing an indication of the presence of the predetermined concentration of carbon dioxide in the sample within a diagnostically effective period of time when the carbon dioxide concentration in the sample is at least about 2% and providing said indication after about ten minutes when the carbon dioxide concentration in the sample is about 0.03%.

2. The method of claim 1 in which said carrier comprises an inert bibulous material.

3. The method of claim 1 in which said carrier comprises an inert fibrous material.

4. The method of claim 1 in which said carrier comprises an inert porous material.

5. The method of claim 1 in which said carrier comprises cellulose.

6. The method of claim 1 in which said diagnostically effective period of time is up to about twenty seconds.

7. The method of claim 6 in which said diagnostically effective period of time is from about two to about ten seconds.

8. The method of claim 1 in which said indication is visually observable.

9. The method of claim 1 in which said indicating composition consists essentially of a chromogenic material, a hygroscopic, water-miscible liquid and an aqueous alkaline solution.

10. The method of claim 9 in which said chromogenic material comprises a chromogenic ph indicator.

11. The method of claim 10 in which the aqueous alkaline solution is a solution of calcium hydroxide and the chromogenic pH indicator is selected from the group comprising metacresol purple and chromogenic pH indicators having pK values substantially the same as metacresol purple.

12. The method of claim 10 in which a predetermined relationship exists between the pH of said indicating composition and the pK of said chromogenic pH indicator.

13. The method of claim 12 in which said chromogenic pH indicator has a pK in said solution which is lower by about 0.5-2.8 pH units than the pH of said aqueous alkaline solution.

14. The method of claim 13 in which said chromogenic pH indicator has a pK which is lower by about 1.0-1.5 pH units than the pH of said aqueous alkaline solution.

15. The method of claim 1 in which said indicating composition comprises predetermined amounts of a base and a hygroscopic material.

16. The method of claim 15 in which the pH of said base is in the range of from about 9.0 to about 10.2.

17. The method of claim 1 in which said indicating composition comprises carbonic anhydrase.

18. A method for determining whether a gaseous sample contains a predetermined concentration of carbon dioxide, comprising contacting the gaseous sample with a detector comprising a carrier to which a dried non-volatile indicating element has been applied, said indicating element providing a first response within a diagnostically effective period of time when the carbon dioxide concentration in the sample is at least about 2% but not providing said first response for more than about ten minutes when the carbon dioxide concentration in the sample is on the order of 0.03%, and providing a second response within said diagnostically effective period of time when the ample is replaced with ambient air.

19. The method of claim 18, in which said first response consists of a first observable color change and said second response consists of a second observable color change.

20. The method of claim 18 in which the sample is collected from a patient and the diagnostically effective period of time is substantially the time for a single breath exhalation or inhalation.

21. A method of making a respiratory gas detector comprising the steps of:

selecting an aqueous alkaline solution;

combining the aqueous alkaline solution with a chromogenic pH-sensitive indicator to form a composition;

correlating the nature and concentration of the composition to the nature and concentration of the pH-sensitive indicator so that the composition produces a predetermined response within a first predetermined period of time to the exposure thereof to carbon dioxide at a concentration of at least about 2% and produces a response for a second predetermined period of time longer than said first predetermined period of time when the composition is exposed only to concentrations of carbon dioxide of no more than about 0.03%;

depositing the composition on a carrier and drying said carrier to form a dry reagent respiratory gas detector.

22. The method of claim 21 further comprising the step of combing the aqueous alkaline solution and chromogenic pH-sensitive indicator with a hygroscopic, water-miscible liquid.

23. The method of claim 21 in which the carrier is cellulose.

24. The method of claim 21 in which said first predetermined period of time is within the range of from less than 2 to about 20 seconds.

25. The method of claim 21 in which said second predetermined period of time is within a period exceeding 10 minutes.