Topical biotin compositions and method of use

• US 5,166,168 A
• Filed: 05/24/1991
• Issued: 11/24/1992
• Est. Priority Date: 05/24/1991
• Status: Expired due to Fees

• Current Assignee: Stiefel Laboratories Incorporated (GlaxoSmithKline PLC)
• Original Assignee: Stiefel Laboratories Incorporated (GlaxoSmithKline PLC)
• Inventors: Stiefel, Werner K.
• Primary Examiner(s): Schenkman, Leonard
• Application Number:
  US07/705,663
• Time in Patent Office: 550 Days
• Field of Search: 514/387
• US Class Current: 514/387
• CPC Class Codes: A61K 31/415 1,2-Diazoles

Abstract

Topical compositions of biotin or a pharmaceutically acceptable salt thereof are used in the treatment of ungual pathologies and to harden ungues in humans.

Claims

1. A method for treating ungual pathologies in humans comprising topically applying to the affected unguis an effective amount of biotin or a pharmaceutically acceptable salt thereof.

2. The method according to claim 1 wherein the biotin or pharmaceutically acceptable salt thereof is topically applied to the affected unguis from one to six times daily.

3. The method according to claim 1 wherein the biotin or pharmaceutically acceptable salt thereof is applied in combination with an ungually acceptable pharmaceutical carrier.

4. The method according to claim 3 wherein the amount of biotin or pharmaceutically acceptable salt thereof is from about 0.01 to about 20.00% by weight of the total composition.

5. A method for hardening ungues in humans comprising topically applying to the ungues an effective amount of biotin or a pharmaceutically acceptable salt thereof.