Iontophoretic delivery method
First Claim
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1. A method of optimizing the transdermal flux of a beneficial agent from an iontophoretic agent delivery device through intact human skin and decreasing inter-patient skin resistance variability, comprising:
- selecting a skin site on intact back skin of the human;
placing the iontophoretic delivery device in agent transmitting relation with the intact back skin site, the delivery device contacting the back skin site over an area of about 1 to 200 cm2 ; and
iontophoretically delivering the agent through the back skin at a pharmaceutically effective rate, at an optimized transdermal flux compared to human skin sites other than back skin and at a transdermal flux which exhibits decreased inter-patient skin resistance variability compared to human skin sites other than back skin.
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Abstract
An improved method for delivering a drug or beneficial agent transdermally to humans by iontophoresis is provided. The method includes selecting and iontophoretically delivering the drug through a skin site which optimizes the transdermal delivery rate of the drug while minimizing inter-patient variability in skin resistance.
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Citations
17 Claims
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1. A method of optimizing the transdermal flux of a beneficial agent from an iontophoretic agent delivery device through intact human skin and decreasing inter-patient skin resistance variability, comprising:
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selecting a skin site on intact back skin of the human; placing the iontophoretic delivery device in agent transmitting relation with the intact back skin site, the delivery device contacting the back skin site over an area of about 1 to 200 cm2 ; and iontophoretically delivering the agent through the back skin at a pharmaceutically effective rate, at an optimized transdermal flux compared to human skin sites other than back skin and at a transdermal flux which exhibits decreased inter-patient skin resistance variability compared to human skin sites other than back skin. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 17)
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11. A method of optimizing transdermal flux of a beneficial agent from an iontophoretic delivery device to a human patient, comprising:
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(a) selecting a skin site on intact back skin of the human patient, (b) placing a donor electrode assembly, which assembly contains a beneficial agent, in agent transmitting relation with the selected intact back skin site, the donor electrode assembly contacting the back skin site over an area of about 0.5 to 100 cm2, (c) placing a counter electrode assembly, which assembly contains an electrolyte, in electrolyte transmitting relation with a skin site spaced apart from the selected intact back skin site, (d) connecting an electric power source to the donor and counter electrode assemblies, and (e) iontophoretically delivering the agent through the back skin at a harmaceutically effective rate, at an optimized transdermal flux compared to human skin sites other than back skin, and at a transdermal flux which exhibits decreased inter-patient skin resistance compared to human skin sites other than back skin. - View Dependent Claims (13, 14, 15, 16)
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Specification