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Iontophoretic delivery method

  • US 5,167,616 A
  • Filed: 12/14/1989
  • Issued: 12/01/1992
  • Est. Priority Date: 12/14/1989
  • Status: Expired due to Term
First Claim
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1. A method of optimizing the transdermal flux of a beneficial agent from an iontophoretic agent delivery device through intact human skin and decreasing inter-patient skin resistance variability, comprising:

  • selecting a skin site on intact back skin of the human;

    placing the iontophoretic delivery device in agent transmitting relation with the intact back skin site, the delivery device contacting the back skin site over an area of about 1 to 200 cm2 ; and

    iontophoretically delivering the agent through the back skin at a pharmaceutically effective rate, at an optimized transdermal flux compared to human skin sites other than back skin and at a transdermal flux which exhibits decreased inter-patient skin resistance variability compared to human skin sites other than back skin.

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